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Gene: PTGIR |
Gene summary for PTGIR |
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Gene information | Species | Human | Gene symbol | PTGIR | Gene ID | 5739 |
Gene name | prostaglandin I2 receptor | |
Gene Alias | IP | |
Cytomap | 19q13.32 | |
Gene Type | protein-coding | GO ID | GO:0002237 | UniProtAcc | P43119 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
5739 | PTGIR | ATC12 | Human | Thyroid | ATC | 4.23e-28 | 5.73e-01 | 0.34 |
5739 | PTGIR | ATC4 | Human | Thyroid | ATC | 2.23e-32 | 6.40e-01 | 0.34 |
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Tissue | Expression Dynamics | Abbreviation |
Thyroid | ![]() | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis | ||
PTC: Papillary thyroid cancer |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004800815 | Thyroid | ATC | platelet-derived growth factor receptor signaling pathway | 36/6293 | 56/18723 | 2.57e-06 | 3.00e-05 | 36 |
GO:003300214 | Thyroid | ATC | muscle cell proliferation | 107/6293 | 248/18723 | 1.03e-03 | 5.47e-03 | 107 |
GO:004865916 | Thyroid | ATC | smooth muscle cell proliferation | 81/6293 | 184/18723 | 2.02e-03 | 9.60e-03 | 81 |
GO:004866016 | Thyroid | ATC | regulation of smooth muscle cell proliferation | 78/6293 | 180/18723 | 4.00e-03 | 1.73e-02 | 78 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PTGIR | SNV | Missense_Mutation | novel | c.686G>A | p.Arg229His | p.R229H | P43119 | protein_coding | deleterious(0.05) | benign(0.031) | TCGA-AA-3947-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PTGIR | SNV | Missense_Mutation | rs200825547 | c.292N>A | p.Ala98Thr | p.A98T | P43119 | protein_coding | tolerated(0.1) | possibly_damaging(0.752) | TCGA-D5-6540-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
PTGIR | SNV | Missense_Mutation | rs200973220 | c.610G>A | p.Gly204Ser | p.G204S | P43119 | protein_coding | tolerated(0.38) | benign(0.059) | TCGA-NH-A50V-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | fluorouracil | CR |
PTGIR | SNV | Missense_Mutation | rs200508770 | c.793G>A | p.Ala265Thr | p.A265T | P43119 | protein_coding | tolerated(0.44) | benign(0.028) | TCGA-AX-A1CE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | SD |
PTGIR | SNV | Missense_Mutation | novel | c.745N>A | p.Ala249Thr | p.A249T | P43119 | protein_coding | tolerated(0.24) | benign(0.007) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
PTGIR | SNV | Missense_Mutation | novel | c.83N>A | p.Val28Glu | p.V28E | P43119 | protein_coding | deleterious(0) | probably_damaging(0.963) | TCGA-PG-A917-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PTGIR | SNV | Missense_Mutation | rs765751581 | c.346N>A | p.Glu116Lys | p.E116K | P43119 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-ED-A7PZ-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
PTGIR | SNV | Missense_Mutation | c.1006N>T | p.Pro336Ser | p.P336S | P43119 | protein_coding | tolerated_low_confidence(0.07) | benign(0.177) | TCGA-LG-A6GG-01 | Liver | liver hepatocellular carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
PTGIR | SNV | Missense_Mutation | c.436N>A | p.Phe146Ile | p.F146I | P43119 | protein_coding | tolerated(0.08) | possibly_damaging(0.574) | TCGA-49-AARN-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
PTGIR | SNV | Missense_Mutation | c.268G>T | p.Ala90Ser | p.A90S | P43119 | protein_coding | tolerated(0.44) | benign(0.017) | TCGA-55-7907-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
5739 | PTGIR | DRUGGABLE GENOME, G PROTEIN COUPLED RECEPTOR | Misoprostol | MISOPROSTOL | ||
5739 | PTGIR | DRUGGABLE GENOME, G PROTEIN COUPLED RECEPTOR | LAROPIPRANT | LAROPIPRANT | ||
5739 | PTGIR | DRUGGABLE GENOME, G PROTEIN COUPLED RECEPTOR | agonist | 135650038 | ||
5739 | PTGIR | DRUGGABLE GENOME, G PROTEIN COUPLED RECEPTOR | antagonist | 318164802 | ||
5739 | PTGIR | DRUGGABLE GENOME, G PROTEIN COUPLED RECEPTOR | agonist | 135649983 | BERAPROST | |
5739 | PTGIR | DRUGGABLE GENOME, G PROTEIN COUPLED RECEPTOR | agonist | 178102478 | ||
5739 | PTGIR | DRUGGABLE GENOME, G PROTEIN COUPLED RECEPTOR | BERAPROST | BERAPROST | ||
5739 | PTGIR | DRUGGABLE GENOME, G PROTEIN COUPLED RECEPTOR | agonist | 135651236 | TAPROSTENE | |
5739 | PTGIR | DRUGGABLE GENOME, G PROTEIN COUPLED RECEPTOR | EPOPROSTENOL | EPOPROSTENOL | ||
5739 | PTGIR | DRUGGABLE GENOME, G PROTEIN COUPLED RECEPTOR | aspirin | ASPIRIN | 17496729 |
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