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Gene: PTCHD1-AS |
Gene summary for PTCHD1-AS |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | PTCHD1-AS | Gene ID | 100873065 |
| Gene name | PTCHD1 antisense RNA (head to head) | |
| Gene Alias | DDX53-AS1 | |
| Cytomap | Xp22.11 | |
| Gene Type | ncRNA | GO ID | NA | UniProtAcc | NA |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 100873065 | PTCHD1-AS | TD9 | Human | Lung | IAC | 2.13e-03 | 7.26e-01 | 0.088 |
| 100873065 | PTCHD1-AS | RNA-P10T2-P10T2-1 | Human | Lung | AAH | 4.97e-07 | 1.06e+00 | -0.1271 |
| 100873065 | PTCHD1-AS | RNA-P10T2-P10T2-2 | Human | Lung | AAH | 7.31e-03 | 6.74e-01 | -0.1406 |
| 100873065 | PTCHD1-AS | RNA-P10T2-P10T2-3 | Human | Lung | AAH | 5.95e-04 | 6.76e-01 | -0.1408 |
| 100873065 | PTCHD1-AS | RNA-P10T2-P10T2-4 | Human | Lung | AAH | 5.54e-03 | 7.39e-01 | -0.138 |
| 100873065 | PTCHD1-AS | RNA-P25T1-P25T1-1 | Human | Lung | AIS | 1.28e-24 | 1.33e+00 | -0.2116 |
| 100873065 | PTCHD1-AS | RNA-P25T1-P25T1-2 | Human | Lung | AIS | 6.92e-13 | 1.20e+00 | -0.1941 |
| 100873065 | PTCHD1-AS | RNA-P25T1-P25T1-3 | Human | Lung | AIS | 1.24e-19 | 1.37e+00 | -0.2107 |
| 100873065 | PTCHD1-AS | RNA-P25T1-P25T1-4 | Human | Lung | AIS | 1.21e-28 | 1.37e+00 | -0.2119 |
| 100873065 | PTCHD1-AS | RNA-P8T2-P8T2-1 | Human | Lung | AIS | 1.39e-07 | 1.29e+00 | -0.1263 |
| 100873065 | PTCHD1-AS | RNA-P8T2-P8T2-3 | Human | Lung | AIS | 2.66e-09 | 1.33e+00 | -0.1284 |
| 100873065 | PTCHD1-AS | RNA-P8T2-P8T2-4 | Human | Lung | AIS | 1.48e-05 | 1.28e+00 | -0.1197 |
| Page: 1 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Lung |  | AAH: Atypical adenomatous hyperplasia |
| AIS: Adenocarcinoma in situ | ||
| IAC: Invasive lung adenocarcinoma | ||
| MIA: Minimally invasive adenocarcinoma |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| Page: 1 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| Page: 1 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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