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Gene: PTAR1 |
Gene summary for PTAR1 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | PTAR1 | Gene ID | 375743 |
| Gene name | protein prenyltransferase alpha subunit repeat containing 1 | |
| Gene Alias | PTAR1 | |
| Cytomap | 9q21.12 | |
| Gene Type | protein-coding | GO ID | GO:0006464 | UniProtAcc | Q7Z6K3 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 375743 | PTAR1 | CCI_2 | Human | Cervix | CC | 7.72e-04 | 6.77e-01 | 0.5249 |
| 375743 | PTAR1 | CCI_3 | Human | Cervix | CC | 1.34e-03 | 5.54e-01 | 0.516 |
| 375743 | PTAR1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 4.32e-22 | -6.25e-01 | 0.0155 |
| 375743 | PTAR1 | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.86e-08 | -5.57e-01 | -0.1808 |
| 375743 | PTAR1 | HTA11_3361_2000001011 | Human | Colorectum | AD | 2.70e-06 | -5.53e-01 | -0.1207 |
| 375743 | PTAR1 | HTA11_83_2000001011 | Human | Colorectum | SER | 6.29e-04 | -5.15e-01 | -0.1526 |
| 375743 | PTAR1 | HTA11_696_2000001011 | Human | Colorectum | AD | 9.24e-12 | -4.62e-01 | -0.1464 |
| 375743 | PTAR1 | HTA11_866_2000001011 | Human | Colorectum | AD | 5.47e-14 | -4.63e-01 | -0.1001 |
| 375743 | PTAR1 | HTA11_1391_2000001011 | Human | Colorectum | AD | 7.12e-08 | -4.63e-01 | -0.059 |
| 375743 | PTAR1 | HTA11_866_3004761011 | Human | Colorectum | AD | 1.20e-11 | -5.27e-01 | 0.096 |
| 375743 | PTAR1 | HTA11_10711_2000001011 | Human | Colorectum | AD | 1.05e-09 | -5.90e-01 | 0.0338 |
| 375743 | PTAR1 | HTA11_7696_3000711011 | Human | Colorectum | AD | 3.42e-22 | -5.53e-01 | 0.0674 |
| 375743 | PTAR1 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 1.65e-15 | -5.05e-01 | 0.3859 |
| 375743 | PTAR1 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 1.42e-05 | -5.84e-01 | 0.2585 |
| 375743 | PTAR1 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 2.11e-26 | -5.89e-01 | 0.3005 |
| 375743 | PTAR1 | F007 | Human | Colorectum | FAP | 7.98e-04 | -3.61e-01 | 0.1176 |
| 375743 | PTAR1 | A002-C-010 | Human | Colorectum | FAP | 8.59e-08 | -2.98e-01 | 0.242 |
| 375743 | PTAR1 | A001-C-207 | Human | Colorectum | FAP | 1.08e-05 | -3.52e-01 | 0.1278 |
| 375743 | PTAR1 | A015-C-203 | Human | Colorectum | FAP | 2.01e-32 | -5.18e-01 | -0.1294 |
| 375743 | PTAR1 | A015-C-204 | Human | Colorectum | FAP | 1.17e-07 | -3.88e-01 | -0.0228 |
| Page: 1 2 3 4 5 6 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Cervix |  | CC: Cervix cancer |
| HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions | ||
| N_HPV: HPV-infected normal cervix | ||
| Colorectum (GSE201348) |  | FAP: Familial adenomatous polyposis |
| CRC: Colorectal cancer | ||
| Colorectum (HTA11) |  | AD: Adenomas |
| SER: Sessile serrated lesions | ||
| MSI-H: Microsatellite-high colorectal cancer | ||
| MSS: Microsatellite stable colorectal cancer | ||
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Skin |  | AK: Actinic keratosis |
| cSCC: Cutaneous squamous cell carcinoma | ||
| SCCIS:squamous cell carcinoma in situ | ||
| Thyroid |  | ATC: Anaplastic thyroid cancer |
| HT: Hashimoto's thyroiditis | ||
| PTC: Papillary thyroid cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| Page: 1 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| PTAR1 | SNV | Missense_Mutation | c.905N>G | p.Leu302Arg | p.L302R | Q7Z6K3 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AO-A0JI-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | SD | |
| PTAR1 | SNV | Missense_Mutation | novel | c.761N>G | p.Asp254Gly | p.D254G | Q7Z6K3 | protein_coding | deleterious(0.01) | benign(0.175) | TCGA-AR-A24N-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| PTAR1 | SNV | Missense_Mutation | novel | c.91G>A | p.Glu31Lys | p.E31K | Q7Z6K3 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-C8-A8HQ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| PTAR1 | SNV | Missense_Mutation | c.197C>G | p.Pro66Arg | p.P66R | Q7Z6K3 | protein_coding | tolerated(0.06) | probably_damaging(0.96) | TCGA-C5-A1M9-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD | |
| PTAR1 | SNV | Missense_Mutation | c.682N>G | p.Ser228Ala | p.S228A | Q7Z6K3 | protein_coding | deleterious(0.04) | benign(0.254) | TCGA-A6-6141-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | 5-fu | SD | |
| PTAR1 | SNV | Missense_Mutation | c.630G>C | p.Lys210Asn | p.K210N | Q7Z6K3 | protein_coding | tolerated(0.18) | benign(0.01) | TCGA-AA-3979-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
| PTAR1 | SNV | Missense_Mutation | c.352A>C | p.Asn118His | p.N118H | Q7Z6K3 | protein_coding | tolerated(0.07) | benign(0.429) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
| PTAR1 | SNV | Missense_Mutation | rs201402192 | c.949N>T | p.Arg317Trp | p.R317W | Q7Z6K3 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-CA-6718-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
| PTAR1 | SNV | Missense_Mutation | rs755835716 | c.26N>T | p.Ala9Val | p.A9V | Q7Z6K3 | protein_coding | deleterious_low_confidence(0.03) | benign(0.072) | TCGA-G4-6628-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
| PTAR1 | SNV | Missense_Mutation | c.1205A>G | p.Gln402Arg | p.Q402R | Q7Z6K3 | protein_coding | deleterious_low_confidence(0.01) | benign(0.057) | TCGA-WS-AB45-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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