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Gene: PSTPIP1 |
Gene summary for PSTPIP1 |
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Gene information | Species | Human | Gene symbol | PSTPIP1 | Gene ID | 9051 |
Gene name | proline-serine-threonine phosphatase interacting protein 1 | |
Gene Alias | CD2BP1 | |
Cytomap | 15q24.3 | |
Gene Type | protein-coding | GO ID | GO:0002376 | UniProtAcc | O43586 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9051 | PSTPIP1 | HCC5 | Human | Liver | HCC | 1.39e-03 | 1.48e+00 | 0.4932 |
9051 | PSTPIP1 | S014 | Human | Liver | HCC | 1.11e-27 | 1.12e+00 | 0.2254 |
9051 | PSTPIP1 | S015 | Human | Liver | HCC | 4.44e-28 | 1.55e+00 | 0.2375 |
9051 | PSTPIP1 | S016 | Human | Liver | HCC | 2.55e-28 | 1.14e+00 | 0.2243 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:005125822 | Liver | HCC | protein polymerization | 182/7958 | 297/18723 | 4.17e-11 | 1.58e-09 | 182 |
GO:000701522 | Liver | HCC | actin filament organization | 252/7958 | 442/18723 | 3.83e-10 | 1.25e-08 | 252 |
GO:000815422 | Liver | HCC | actin polymerization or depolymerization | 130/7958 | 218/18723 | 2.31e-07 | 4.14e-06 | 130 |
GO:003004122 | Liver | HCC | actin filament polymerization | 116/7958 | 191/18723 | 2.66e-07 | 4.68e-06 | 116 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PSTPIP1 | SNV | Missense_Mutation | rs754304151 | c.185N>A | p.Arg62Gln | p.R62Q | O43586 | protein_coding | deleterious(0) | probably_damaging(0.945) | TCGA-A2-A0YM-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PSTPIP1 | SNV | Missense_Mutation | novel | c.1007N>G | p.Pro336Arg | p.P336R | O43586 | protein_coding | deleterious(0.01) | benign(0.003) | TCGA-D8-A143-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD |
PSTPIP1 | SNV | Missense_Mutation | c.255N>C | p.Glu85Asp | p.E85D | O43586 | protein_coding | tolerated(0.37) | probably_damaging(0.988) | TCGA-JW-A852-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD | |
PSTPIP1 | SNV | Missense_Mutation | novel | c.875N>C | p.Val292Ala | p.V292A | O43586 | protein_coding | tolerated(1) | benign(0) | TCGA-AA-3947-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PSTPIP1 | SNV | Missense_Mutation | novel | c.150G>T | p.Glu50Asp | p.E50D | O43586 | protein_coding | deleterious(0.01) | possibly_damaging(0.78) | TCGA-AD-6964-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | folfox | PD |
PSTPIP1 | SNV | Missense_Mutation | c.787N>A | p.Ala263Thr | p.A263T | O43586 | protein_coding | tolerated(0.68) | benign(0) | TCGA-D5-6540-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
PSTPIP1 | SNV | Missense_Mutation | rs372468528 | c.1015G>A | p.Glu339Lys | p.E339K | O43586 | protein_coding | tolerated(0.11) | benign(0.022) | TCGA-F4-6570-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PSTPIP1 | SNV | Missense_Mutation | rs768664787 | c.1019N>A | p.Arg340Gln | p.R340Q | O43586 | protein_coding | tolerated(0.29) | benign(0.001) | TCGA-WS-AB45-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PSTPIP1 | SNV | Missense_Mutation | novel | c.1178N>G | p.Glu393Gly | p.E393G | O43586 | protein_coding | deleterious(0.03) | benign(0.091) | TCGA-EI-6514-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Chemotherapy | 5-fu | SD |
PSTPIP1 | SNV | Missense_Mutation | novel | c.1030N>A | p.Val344Ile | p.V344I | O43586 | protein_coding | tolerated(0.13) | benign(0.282) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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