Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: PSMB7

Gene summary for PSMB7

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

PSMB7

Gene ID

5695

Gene nameproteasome 20S subunit beta 7
Gene AliasZ
Cytomap9q33.3
Gene Typeprotein-coding
GO ID

GO:0006508

UniProtAcc

E9KL30


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
5695PSMB7HTA11_3410_2000001011HumanColorectumAD1.61e-022.17e-010.0155
5695PSMB7HTA11_2487_2000001011HumanColorectumSER1.71e-076.47e-01-0.1808
5695PSMB7HTA11_1938_2000001011HumanColorectumAD1.22e-096.93e-01-0.0811
5695PSMB7HTA11_78_2000001011HumanColorectumAD1.01e-095.83e-01-0.1088
5695PSMB7HTA11_347_2000001011HumanColorectumAD1.20e-196.70e-01-0.1954
5695PSMB7HTA11_83_2000001011HumanColorectumSER1.08e-056.29e-01-0.1526
5695PSMB7HTA11_696_2000001011HumanColorectumAD4.59e-206.97e-01-0.1464
5695PSMB7HTA11_866_2000001011HumanColorectumAD6.86e-043.15e-01-0.1001
5695PSMB7HTA11_1391_2000001011HumanColorectumAD6.60e-168.07e-01-0.059
5695PSMB7HTA11_2992_2000001011HumanColorectumSER7.03e-078.56e-01-0.1706
5695PSMB7HTA11_5216_2000001011HumanColorectumSER1.01e-035.67e-01-0.1462
5695PSMB7HTA11_546_2000001011HumanColorectumAD1.93e-055.62e-01-0.0842
5695PSMB7HTA11_7862_2000001011HumanColorectumAD3.80e-035.00e-01-0.0179
5695PSMB7HTA11_866_3004761011HumanColorectumAD9.48e-198.44e-010.096
5695PSMB7HTA11_8622_2000001021HumanColorectumSER1.83e-036.43e-010.0528
5695PSMB7HTA11_7663_2000001011HumanColorectumSER1.67e-057.69e-010.0131
5695PSMB7HTA11_6801_2000001011HumanColorectumSER1.62e-061.01e+000.0171
5695PSMB7HTA11_10711_2000001011HumanColorectumAD1.79e-024.32e-010.0338
5695PSMB7HTA11_7696_3000711011HumanColorectumAD3.85e-176.70e-010.0674
5695PSMB7HTA11_6818_2000001021HumanColorectumAD1.13e-065.70e-010.0588
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
Colorectum (GSE201348)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.FAP: Familial adenomatous polyposis
CRC: Colorectal cancer
Colorectum (HTA11)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AD: Adenomas
SER: Sessile serrated lesions
MSI-H: Microsatellite-high colorectal cancer
MSS: Microsatellite stable colorectal cancer
EndometriumThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AEH: Atypical endometrial hyperplasia
EEC: Endometrioid Cancer
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
ProstateThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.BPH: Benign Prostatic Hyperplasia
SkinThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AK: Actinic keratosis
cSCC: Cutaneous squamous cell carcinoma
SCCIS:squamous cell carcinoma in situ
ThyroidThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ATC: Anaplastic thyroid cancer
HT: Hashimoto's thyroiditis
PTC: Papillary thyroid cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:0010498ColorectumADproteasomal protein catabolic process174/3918490/187233.18e-147.66e-12174
GO:00104981ColorectumSERproteasomal protein catabolic process132/2897490/187233.08e-115.55e-09132
GO:00104982ColorectumMSSproteasomal protein catabolic process157/3467490/187232.39e-135.25e-11157
GO:00104983ColorectumMSI-Hproteasomal protein catabolic process71/1319490/187234.67e-096.03e-0771
GO:00104984ColorectumFAPproteasomal protein catabolic process110/2622490/187232.12e-071.26e-05110
GO:001049816EndometriumAEHproteasomal protein catabolic process108/2100490/187232.73e-124.67e-10108
GO:001049817EndometriumEECproteasomal protein catabolic process112/2168490/187236.99e-131.40e-10112
GO:0010498111EsophagusESCCproteasomal protein catabolic process369/8552490/187231.13e-411.80e-38369
GO:001049812LiverCirrhoticproteasomal protein catabolic process216/4634490/187232.52e-219.29e-19216
GO:001049822LiverHCCproteasomal protein catabolic process351/7958490/187236.92e-401.46e-36351
GO:001049820Oral cavityOSCCproteasomal protein catabolic process336/7305490/187235.45e-418.63e-38336
GO:0010498110Oral cavityLPproteasomal protein catabolic process224/4623490/187239.57e-254.00e-22224
GO:001049818ProstateBPHproteasomal protein catabolic process153/3107490/187234.13e-167.51e-14153
GO:001049819ProstateTumorproteasomal protein catabolic process158/3246490/187233.05e-166.76e-14158
GO:001049828SkincSCCproteasomal protein catabolic process243/4864490/187237.85e-304.10e-27243
GO:0010498113ThyroidPTCproteasomal protein catabolic process297/5968490/187234.58e-409.63e-37297
GO:001049832ThyroidATCproteasomal protein catabolic process309/6293490/187231.78e-411.13e-37309
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
hsa05012ColorectumADParkinson disease147/2092266/84652.53e-278.48e-255.41e-25147
hsa05010ColorectumADAlzheimer disease174/2092384/84651.82e-199.26e-185.91e-18174
hsa05016ColorectumADHuntington disease147/2092306/84651.93e-199.26e-185.91e-18147
hsa05020ColorectumADPrion disease133/2092273/84652.47e-188.29e-175.29e-17133
hsa05014ColorectumADAmyotrophic lateral sclerosis164/2092364/84654.28e-181.27e-168.09e-17164
hsa05022ColorectumADPathways of neurodegeneration - multiple diseases201/2092476/84654.54e-181.27e-168.09e-17201
hsa03050ColorectumADProteasome29/209246/84653.87e-086.18e-073.94e-0729
hsa05017ColorectumADSpinocerebellar ataxia60/2092143/84653.78e-064.35e-052.78e-0560
hsa050121ColorectumADParkinson disease147/2092266/84652.53e-278.48e-255.41e-25147
hsa050101ColorectumADAlzheimer disease174/2092384/84651.82e-199.26e-185.91e-18174
hsa050161ColorectumADHuntington disease147/2092306/84651.93e-199.26e-185.91e-18147
hsa050201ColorectumADPrion disease133/2092273/84652.47e-188.29e-175.29e-17133
hsa050141ColorectumADAmyotrophic lateral sclerosis164/2092364/84654.28e-181.27e-168.09e-17164
hsa050221ColorectumADPathways of neurodegeneration - multiple diseases201/2092476/84654.54e-181.27e-168.09e-17201
hsa030501ColorectumADProteasome29/209246/84653.87e-086.18e-073.94e-0729
hsa050171ColorectumADSpinocerebellar ataxia60/2092143/84653.78e-064.35e-052.78e-0560
hsa050122ColorectumSERParkinson disease132/1580266/84652.72e-319.03e-296.55e-29132
hsa050202ColorectumSERPrion disease119/1580273/84654.61e-223.06e-202.22e-20119
hsa050162ColorectumSERHuntington disease127/1580306/84653.29e-211.37e-199.92e-20127
hsa050102ColorectumSERAlzheimer disease146/1580384/84656.52e-202.40e-181.75e-18146
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
PSMB7SNVMissense_Mutationrs149845424c.134C>Tp.Thr45Ilep.T45IQ99436protein_codingdeleterious(0)probably_damaging(0.999)TCGA-A6-6654-01Colorectumcolon adenocarcinomaFemale>=65III/IVChemotherapyoxaliplatinSD
PSMB7SNVMissense_Mutationnovelc.602N>Tp.Ala201Valp.A201VQ99436protein_codingdeleterious(0)probably_damaging(0.963)TCGA-AA-3956-01Colorectumcolon adenocarcinomaMale>=65I/IIUnknownUnknownSD
PSMB7SNVMissense_Mutationrs375266282c.370N>Tp.Arg124Trpp.R124WQ99436protein_codingtolerated(0.08)probably_damaging(0.949)TCGA-AJ-A3EL-01Endometriumuterine corpus endometrioid carcinomaFemale<65I/IIUnknownUnknownSD
PSMB7SNVMissense_Mutationnovelc.169N>Ap.Leu57Ilep.L57IQ99436protein_codingtolerated(0.15)possibly_damaging(0.654)TCGA-AP-A1DV-01Endometriumuterine corpus endometrioid carcinomaFemale<65I/IIUnknownUnknownSD
PSMB7SNVMissense_Mutationnovelc.260N>Ap.Cys87Tyrp.C87YQ99436protein_codingdeleterious(0.01)probably_damaging(0.996)TCGA-AX-A2HD-01Endometriumuterine corpus endometrioid carcinomaFemale>=65III/IVUnknownUnknownSD
PSMB7SNVMissense_Mutationnovelc.8C>Ap.Ala3Aspp.A3DQ99436protein_codingtolerated(0.2)benign(0.003)TCGA-B5-A3FC-01Endometriumuterine corpus endometrioid carcinomaFemale<65I/IIUnknownUnknownSD
PSMB7SNVMissense_Mutationrs369427242c.658N>Ap.Val220Ilep.V220IQ99436protein_codingtolerated(0.16)benign(0.097)TCGA-BG-A221-01Endometriumuterine corpus endometrioid carcinomaFemale>=65I/IIUnknownUnknownSD
PSMB7SNVMissense_Mutationrs142971341c.607N>Ap.Ala203Thrp.A203TQ99436protein_codingtolerated(0.71)benign(0.006)TCGA-DF-A2KU-01Endometriumuterine corpus endometrioid carcinomaFemaleUnknownI/IIUnknownUnknownSD
PSMB7SNVMissense_Mutationnovelc.669N>Tp.Lys223Asnp.K223NQ99436protein_codingtolerated(0.06)benign(0.047)TCGA-E6-A1LX-01Endometriumuterine corpus endometrioid carcinomaFemale<65I/IIUnknownUnknownSD
PSMB7SNVMissense_Mutationrs749255446c.812N>Cp.Val271Alap.V271AQ99436protein_codingdeleterious(0.03)benign(0.082)TCGA-EC-A24G-01Endometriumuterine corpus endometrioid carcinomaFemale<65I/IIChemotherapydoxorubicinSD
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
5695PSMB7DRUGGABLE GENOME, PROTEASEinhibitorCARFILZOMIBCARFILZOMIB
5695PSMB7DRUGGABLE GENOME, PROTEASEinhibitorCHEMBL3545432IXAZOMIB CITRATE
5695PSMB7DRUGGABLE GENOME, PROTEASEinhibitorCHEMBL371405MARIZOMIB
5695PSMB7DRUGGABLE GENOME, PROTEASEBORTEZOMIBBORTEZOMIB24524217
5695PSMB7DRUGGABLE GENOME, PROTEASEinhibitorCHEMBL2103884OPROZOMIB
5695PSMB7DRUGGABLE GENOME, PROTEASEinhibitorCHEMBL325041BORTEZOMIB
5695PSMB7DRUGGABLE GENOME, PROTEASEinhibitorBORTEZOMIBBORTEZOMIB
5695PSMB7DRUGGABLE GENOME, PROTEASECARFILZOMIBCARFILZOMIB24524217
5695PSMB7DRUGGABLE GENOME, PROTEASEinhibitorCHEMBL451887CARFILZOMIB
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