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Gene: PRXL2B |
Gene summary for PRXL2B |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | PRXL2B | Gene ID | 127281 |
| Gene name | peroxiredoxin like 2B | |
| Gene Alias | C1orf93 | |
| Cytomap | 1p36.32 | |
| Gene Type | protein-coding | GO ID | GO:0001516 | UniProtAcc | A0A0A0MT35 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 127281 | PRXL2B | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.41e-07 | 1.84e-01 | 0.0155 |
| 127281 | PRXL2B | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.36e-22 | 6.15e-01 | -0.1808 |
| 127281 | PRXL2B | HTA11_1938_2000001011 | Human | Colorectum | AD | 8.58e-13 | 4.12e-01 | -0.0811 |
| 127281 | PRXL2B | HTA11_78_2000001011 | Human | Colorectum | AD | 6.14e-23 | 5.27e-01 | -0.1088 |
| 127281 | PRXL2B | HTA11_347_2000001011 | Human | Colorectum | AD | 1.13e-40 | 7.43e-01 | -0.1954 |
| 127281 | PRXL2B | HTA11_411_2000001011 | Human | Colorectum | SER | 3.33e-15 | 8.79e-01 | -0.2602 |
| 127281 | PRXL2B | HTA11_2112_2000001011 | Human | Colorectum | SER | 1.50e-04 | 3.37e-01 | -0.2196 |
| 127281 | PRXL2B | HTA11_3361_2000001011 | Human | Colorectum | AD | 4.57e-06 | 2.02e-01 | -0.1207 |
| 127281 | PRXL2B | HTA11_83_2000001011 | Human | Colorectum | SER | 1.46e-11 | 3.83e-01 | -0.1526 |
| 127281 | PRXL2B | HTA11_696_2000001011 | Human | Colorectum | AD | 7.63e-19 | 3.82e-01 | -0.1464 |
| 127281 | PRXL2B | HTA11_866_2000001011 | Human | Colorectum | AD | 9.32e-10 | 2.36e-01 | -0.1001 |
| 127281 | PRXL2B | HTA11_1391_2000001011 | Human | Colorectum | AD | 2.20e-22 | 5.83e-01 | -0.059 |
| 127281 | PRXL2B | HTA11_2992_2000001011 | Human | Colorectum | SER | 2.50e-12 | 5.06e-01 | -0.1706 |
| 127281 | PRXL2B | HTA11_5212_2000001011 | Human | Colorectum | AD | 2.57e-15 | 4.96e-01 | -0.2061 |
| 127281 | PRXL2B | HTA11_5216_2000001011 | Human | Colorectum | SER | 3.22e-05 | 3.63e-01 | -0.1462 |
| 127281 | PRXL2B | HTA11_546_2000001011 | Human | Colorectum | AD | 1.43e-09 | 3.33e-01 | -0.0842 |
| 127281 | PRXL2B | HTA11_7862_2000001011 | Human | Colorectum | AD | 2.47e-08 | 3.55e-01 | -0.0179 |
| 127281 | PRXL2B | HTA11_866_3004761011 | Human | Colorectum | AD | 2.40e-11 | 2.93e-01 | 0.096 |
| 127281 | PRXL2B | HTA11_4255_2000001011 | Human | Colorectum | SER | 3.03e-06 | 3.89e-01 | 0.0446 |
| 127281 | PRXL2B | HTA11_8622_2000001021 | Human | Colorectum | SER | 3.89e-10 | 4.03e-01 | 0.0528 |
| Page: 1 2 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Colorectum (GSE201348) |  | FAP: Familial adenomatous polyposis |
| CRC: Colorectal cancer | ||
| Colorectum (HTA11) |  | AD: Adenomas |
| SER: Sessile serrated lesions | ||
| MSI-H: Microsatellite-high colorectal cancer | ||
| MSS: Microsatellite stable colorectal cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:0009636 | Colorectum | AD | response to toxic substance | 88/3918 | 262/18723 | 1.12e-06 | 3.72e-05 | 88 |
| GO:0098754 | Colorectum | AD | detoxification | 53/3918 | 152/18723 | 4.63e-05 | 7.98e-04 | 53 |
| GO:0006631 | Colorectum | AD | fatty acid metabolic process | 114/3918 | 390/18723 | 5.58e-05 | 9.44e-04 | 114 |
| GO:0097237 | Colorectum | AD | cellular response to toxic substance | 44/3918 | 124/18723 | 1.24e-04 | 1.80e-03 | 44 |
| GO:1990748 | Colorectum | AD | cellular detoxification | 41/3918 | 116/18723 | 2.29e-04 | 2.97e-03 | 41 |
| GO:0098869 | Colorectum | AD | cellular oxidant detoxification | 33/3918 | 101/18723 | 3.88e-03 | 2.72e-02 | 33 |
| GO:00096361 | Colorectum | SER | response to toxic substance | 71/2897 | 262/18723 | 8.63e-07 | 4.07e-05 | 71 |
| GO:00972371 | Colorectum | SER | cellular response to toxic substance | 40/2897 | 124/18723 | 2.28e-06 | 9.43e-05 | 40 |
| GO:00987541 | Colorectum | SER | detoxification | 46/2897 | 152/18723 | 3.02e-06 | 1.20e-04 | 46 |
| GO:19907481 | Colorectum | SER | cellular detoxification | 37/2897 | 116/18723 | 7.20e-06 | 2.48e-04 | 37 |
| GO:00988691 | Colorectum | SER | cellular oxidant detoxification | 31/2897 | 101/18723 | 8.73e-05 | 1.91e-03 | 31 |
| GO:00066311 | Colorectum | SER | fatty acid metabolic process | 79/2897 | 390/18723 | 6.34e-03 | 4.56e-02 | 79 |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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