Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: PRXL2A

Gene summary for PRXL2A

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

PRXL2A

Gene ID

84293

Gene nameperoxiredoxin like 2A
Gene AliasAdrx
Cytomap10q23.1
Gene Typeprotein-coding
GO ID

GO:0002376

UniProtAcc

Q9BRX8


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
84293PRXL2ACA_HPV_1HumanCervixCC3.95e-13-4.22e-010.0264
84293PRXL2ACA_HPV_3HumanCervixCC5.86e-037.12e-020.0414
84293PRXL2AHSIL_HPV_2HumanCervixHSIL_HPV3.08e-02-2.83e-010.0208
84293PRXL2AN_HPV_1HumanCervixN_HPV5.99e-06-4.07e-010.0079
84293PRXL2ACCII_1HumanCervixCC5.11e-09-5.86e-010.3249
84293PRXL2ATumorHumanCervixCC1.03e-36-6.53e-010.1241
84293PRXL2AT1HumanCervixCC4.30e-02-3.04e-010.0918
84293PRXL2AT3HumanCervixCC1.12e-038.60e-020.1389
84293PRXL2AHTA11_3410_2000001011HumanColorectumAD5.97e-325.28e-010.0155
84293PRXL2AHTA11_2487_2000001011HumanColorectumSER6.12e-461.00e+00-0.1808
84293PRXL2AHTA11_2951_2000001011HumanColorectumAD6.82e-156.74e-010.0216
84293PRXL2AHTA11_1938_2000001011HumanColorectumAD2.25e-381.04e+00-0.0811
84293PRXL2AHTA11_78_2000001011HumanColorectumAD3.30e-297.10e-01-0.1088
84293PRXL2AHTA11_347_2000001011HumanColorectumAD1.36e-801.33e+00-0.1954
84293PRXL2AHTA11_411_2000001011HumanColorectumSER7.44e-096.61e-01-0.2602
84293PRXL2AHTA11_2112_2000001011HumanColorectumSER5.26e-105.85e-01-0.2196
84293PRXL2AHTA11_3361_2000001011HumanColorectumAD3.79e-246.88e-01-0.1207
84293PRXL2AHTA11_83_2000001011HumanColorectumSER5.94e-401.36e+00-0.1526
84293PRXL2AHTA11_696_2000001011HumanColorectumAD3.14e-467.81e-01-0.1464
84293PRXL2AHTA11_866_2000001011HumanColorectumAD4.96e-356.69e-01-0.1001
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
CervixThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.CC: Cervix cancer
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions
N_HPV: HPV-infected normal cervix
Colorectum (GSE201348)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.FAP: Familial adenomatous polyposis
CRC: Colorectal cancer
Colorectum (HTA11)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AD: Adenomas
SER: Sessile serrated lesions
MSI-H: Microsatellite-high colorectal cancer
MSS: Microsatellite stable colorectal cancer
EndometriumThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AEH: Atypical endometrial hyperplasia
EEC: Endometrioid Cancer
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
ProstateThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.BPH: Benign Prostatic Hyperplasia
SkinThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AK: Actinic keratosis
cSCC: Cutaneous squamous cell carcinoma
SCCIS:squamous cell carcinoma in situ
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:003009910CervixCCmyeloid cell differentiation83/2311381/187231.31e-076.42e-0683
GO:190370610CervixCCregulation of hemopoiesis80/2311367/187232.14e-079.55e-0680
GO:00988699CervixCCcellular oxidant detoxification30/2311101/187232.72e-067.93e-0530
GO:19021056CervixCCregulation of leukocyte differentiation61/2311279/187235.16e-061.29e-0461
GO:004563710CervixCCregulation of myeloid cell differentiation48/2311210/187231.49e-052.93e-0448
GO:00025738CervixCCmyeloid leukocyte differentiation47/2311208/187232.48e-054.27e-0447
GO:19907489CervixCCcellular detoxification30/2311116/187235.34e-057.94e-0430
GO:00972379CervixCCcellular response to toxic substance31/2311124/187238.09e-051.10e-0331
GO:00096369CervixCCresponse to toxic substance52/2311262/187233.34e-043.52e-0352
GO:00987549CervixCCdetoxification33/2311152/187237.97e-047.00e-0333
GO:00027614CervixCCregulation of myeloid leukocyte differentiation27/2311120/187231.31e-031.04e-0227
GO:0030316CervixCCosteoclast differentiation20/231194/187239.92e-034.86e-0220
GO:003009915CervixHSIL_HPVmyeloid cell differentiation36/737381/187231.19e-065.62e-0536
GO:190370613CervixHSIL_HPVregulation of hemopoiesis35/737367/187231.35e-066.21e-0535
GO:190210512CervixHSIL_HPVregulation of leukocyte differentiation28/737279/187235.84e-062.13e-0428
GO:000257313CervixHSIL_HPVmyeloid leukocyte differentiation22/737208/187232.56e-057.56e-0422
GO:004563715CervixHSIL_HPVregulation of myeloid cell differentiation22/737210/187232.97e-058.57e-0422
GO:000963614CervixHSIL_HPVresponse to toxic substance24/737262/187231.14e-042.36e-0324
GO:009886914CervixHSIL_HPVcellular oxidant detoxification13/737101/187231.64e-043.14e-0313
GO:000276112CervixHSIL_HPVregulation of myeloid leukocyte differentiation14/737120/187232.67e-044.54e-0314
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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