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Gene: PRSS27 |
Gene summary for PRSS27 |
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Gene information | Species | Human | Gene symbol | PRSS27 | Gene ID | 83886 |
Gene name | serine protease 27 | |
Gene Alias | CAPH2 | |
Cytomap | 16p13.3 | |
Gene Type | protein-coding | GO ID | GO:0006508 | UniProtAcc | Q9BQR3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
83886 | PRSS27 | H2 | Human | Cervix | HSIL_HPV | 2.00e-29 | 7.60e-01 | 0.0632 |
83886 | PRSS27 | L1 | Human | Cervix | CC | 1.14e-02 | 2.72e-01 | 0.0802 |
83886 | PRSS27 | P1T-E | Human | Esophagus | ESCC | 1.04e-02 | 6.75e-01 | 0.0875 |
83886 | PRSS27 | P39T-E | Human | Esophagus | ESCC | 2.20e-17 | 1.45e+00 | 0.0894 |
83886 | PRSS27 | P47T-E | Human | Esophagus | ESCC | 1.66e-02 | 3.39e-01 | 0.1067 |
83886 | PRSS27 | P74T-E | Human | Esophagus | ESCC | 2.00e-05 | 1.05e+00 | 0.1479 |
83886 | PRSS27 | P84T-E | Human | Esophagus | ESCC | 1.83e-05 | 2.77e+00 | 0.0933 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PRSS27 | SNV | Missense_Mutation | c.768N>C | p.Gln256His | p.Q256H | Q9BQR3 | protein_coding | deleterious(0.02) | benign(0.382) | TCGA-C8-A26Y-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
PRSS27 | insertion | Frame_Shift_Ins | novel | c.641_642insGTTGATAGAGCAAGACTCTATTTTATTAAGAA | p.Cys214TrpfsTer44 | p.C214Wfs*44 | Q9BQR3 | protein_coding | TCGA-EW-A1OZ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Targeted Molecular therapy | trastuzumab | SD | ||
PRSS27 | SNV | Missense_Mutation | rs770792515 | c.427N>A | p.Val143Met | p.V143M | Q9BQR3 | protein_coding | deleterious(0) | probably_damaging(0.979) | TCGA-A6-6653-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
PRSS27 | SNV | Missense_Mutation | novel | c.744N>A | p.Ser248Arg | p.S248R | Q9BQR3 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR |
PRSS27 | SNV | Missense_Mutation | rs763261442 | c.304N>A | p.Ala102Thr | p.A102T | Q9BQR3 | protein_coding | tolerated(0.24) | possibly_damaging(0.604) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
PRSS27 | SNV | Missense_Mutation | rs201349935 | c.248N>T | p.Thr83Met | p.T83M | Q9BQR3 | protein_coding | tolerated(0.19) | benign(0.084) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PRSS27 | SNV | Missense_Mutation | novel | c.284T>C | p.Leu95Pro | p.L95P | Q9BQR3 | protein_coding | deleterious(0) | probably_damaging(0.985) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PRSS27 | SNV | Missense_Mutation | rs779962045 | c.821N>A | p.Arg274Gln | p.R274Q | Q9BQR3 | protein_coding | tolerated(0.16) | benign(0) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD |
PRSS27 | SNV | Missense_Mutation | novel | c.580C>T | p.Leu194Phe | p.L194F | Q9BQR3 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-DI-A1BU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD |
PRSS27 | SNV | Missense_Mutation | rs201349935 | c.248N>T | p.Thr83Met | p.T83M | Q9BQR3 | protein_coding | tolerated(0.19) | benign(0.084) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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