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Gene: PRSS1 |
Gene summary for PRSS1 |
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Gene information | Species | Human | Gene symbol | PRSS1 | Gene ID | 5644 |
Gene name | serine protease 1 | |
Gene Alias | TRP1 | |
Cytomap | 7q34 | |
Gene Type | protein-coding | GO ID | GO:0006508 | UniProtAcc | P07477 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
5644 | PRSS1 | HTA12-15-2 | Human | Pancreas | PDAC | 2.63e-53 | -2.85e+00 | 0.2315 |
5644 | PRSS1 | HTA12-16-6 | Human | Pancreas | PDAC | 1.78e-03 | -7.07e-02 | 0.0544 |
5644 | PRSS1 | HTA12-23-1 | Human | Pancreas | PDAC | 9.09e-39 | -2.85e+00 | 0.3405 |
5644 | PRSS1 | HTA12-25-1 | Human | Pancreas | PDAC | 2.08e-52 | -2.85e+00 | 0.313 |
5644 | PRSS1 | HTA12-26-1 | Human | Pancreas | PDAC | 7.53e-62 | -2.85e+00 | 0.3728 |
5644 | PRSS1 | HTA12-29-1 | Human | Pancreas | PDAC | 2.80e-133 | -2.85e+00 | 0.3722 |
5644 | PRSS1 | HTA12-3-16 | Human | Pancreas | PDAC | 2.87e-15 | -2.85e+00 | 0.1553 |
5644 | PRSS1 | HTA12-30-1 | Human | Pancreas | PDAC | 9.52e-17 | -2.85e+00 | 0.3671 |
5644 | PRSS1 | HTA12-32-1 | Human | Pancreas | PDAC | 8.14e-53 | -2.17e+00 | 0.3624 |
5644 | PRSS1 | HTA12-9-1 | Human | Pancreas | PDAC | 7.64e-90 | -2.62e+00 | 0.1532 |
5644 | PRSS1 | HTA12-9-2 | Human | Pancreas | PDAC | 1.50e-17 | -2.62e-01 | 0.0835 |
5644 | PRSS1 | HTA12-9-3 | Human | Pancreas | PDAC | 1.00e-84 | -2.16e+00 | 0.2045 |
5644 | PRSS1 | 3829-EC | Human | Pancreas | PanIN | 3.14e-107 | -2.19e-01 | 0.009 |
5644 | PRSS1 | 4347-EC | Human | Pancreas | PanIN | 3.63e-31 | -1.10e-01 | 0.0572 |
5644 | PRSS1 | 181429 | Human | Pancreas | PDAC | 3.62e-26 | -2.85e+00 | 0.1416 |
5644 | PRSS1 | 61354830 | Human | Pancreas | PDAC | 9.52e-17 | -2.85e+00 | 0.1458 |
5644 | PRSS1 | DS20191261Tumor | Human | Pancreas | PDAC | 1.09e-92 | -2.85e+00 | 0.1367 |
5644 | PRSS1 | DS20191261TumorKeller | Human | Pancreas | PDAC | 3.69e-32 | -2.85e+00 | 0.1407 |
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Tissue | Expression Dynamics | Abbreviation |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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