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Gene: PRRX2 |
Gene summary for PRRX2 |
Gene summary. |
Gene information | Species | Human | Gene symbol | PRRX2 | Gene ID | 51450 |
Gene name | paired related homeobox 2 | |
Gene Alias | PMX2 | |
Cytomap | 9q34.11 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | A0A140VJS2 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
51450 | PRRX2 | C30 | Human | Oral cavity | OSCC | 5.82e-45 | 2.52e+00 | 0.3055 |
51450 | PRRX2 | C08 | Human | Oral cavity | OSCC | 3.53e-04 | 9.73e-02 | 0.1919 |
51450 | PRRX2 | NEOLP-1 | Human | Oral cavity | NEOLP | 5.89e-11 | 4.65e-01 | -0.0194 |
51450 | PRRX2 | NEOLP-2 | Human | Oral cavity | NEOLP | 6.11e-08 | 3.29e-01 | -0.0196 |
51450 | PRRX2 | NEOLP-3 | Human | Oral cavity | NEOLP | 1.25e-08 | 3.03e-01 | -0.0191 |
51450 | PRRX2 | SYSMH1 | Human | Oral cavity | OSCC | 1.99e-26 | 6.21e-01 | 0.1127 |
51450 | PRRX2 | ATC13 | Human | Thyroid | ATC | 1.36e-52 | 1.16e+00 | 0.34 |
51450 | PRRX2 | ATC5 | Human | Thyroid | ATC | 1.51e-53 | 1.23e+00 | 0.34 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PRRX2 | SNV | Missense_Mutation | rs769856483 | c.316N>T | p.Arg106Trp | p.R106W | Q99811 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
PRRX2 | SNV | Missense_Mutation | novel | c.418C>T | p.Arg140Cys | p.R140C | Q99811 | protein_coding | deleterious(0) | probably_damaging(0.987) | TCGA-EA-A3HS-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
PRRX2 | SNV | Missense_Mutation | c.459N>C | p.Gln153His | p.Q153H | Q99811 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-FU-A3YQ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
PRRX2 | SNV | Missense_Mutation | novel | c.281N>A | p.Arg94His | p.R94H | Q99811 | protein_coding | deleterious(0.03) | benign(0) | TCGA-AA-3947-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PRRX2 | SNV | Missense_Mutation | rs745318451 | c.697G>A | p.Ala233Thr | p.A233T | Q99811 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
PRRX2 | SNV | Missense_Mutation | novel | c.592G>T | p.Asp198Tyr | p.D198Y | Q99811 | protein_coding | deleterious(0) | possibly_damaging(0.862) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR |
PRRX2 | SNV | Missense_Mutation | rs766187907 | c.509N>A | p.Arg170His | p.R170H | Q99811 | protein_coding | deleterious(0.05) | possibly_damaging(0.7) | TCGA-CM-6171-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PRRX2 | insertion | Frame_Shift_Ins | novel | c.616_617insC | p.Tyr208LeufsTer133 | p.Y208Lfs*133 | Q99811 | protein_coding | TCGA-A6-5665-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | ||
PRRX2 | SNV | Missense_Mutation | c.467G>A | p.Arg156His | p.R156H | Q99811 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-A5-A0GP-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
PRRX2 | SNV | Missense_Mutation | c.467N>A | p.Arg156His | p.R156H | Q99811 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-B5-A11N-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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