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Gene: PRR13 |
Gene summary for PRR13 |
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Gene information | Species | Human | Gene symbol | PRR13 | Gene ID | 54458 |
Gene name | proline rich 13 | |
Gene Alias | TXR1 | |
Cytomap | 12q13.13 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q9NZ81 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
54458 | PRR13 | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.80e-08 | 2.78e-01 | 0.0155 |
54458 | PRR13 | HTA11_2487_2000001011 | Human | Colorectum | SER | 2.68e-25 | 1.07e+00 | -0.1808 |
54458 | PRR13 | HTA11_1938_2000001011 | Human | Colorectum | AD | 1.51e-13 | 9.32e-01 | -0.0811 |
54458 | PRR13 | HTA11_78_2000001011 | Human | Colorectum | AD | 5.47e-14 | 7.46e-01 | -0.1088 |
54458 | PRR13 | HTA11_347_2000001011 | Human | Colorectum | AD | 9.75e-34 | 9.99e-01 | -0.1954 |
54458 | PRR13 | HTA11_411_2000001011 | Human | Colorectum | SER | 3.98e-10 | 1.33e+00 | -0.2602 |
54458 | PRR13 | HTA11_2112_2000001011 | Human | Colorectum | SER | 1.49e-05 | 1.17e+00 | -0.2196 |
54458 | PRR13 | HTA11_3361_2000001011 | Human | Colorectum | AD | 4.19e-09 | 5.33e-01 | -0.1207 |
54458 | PRR13 | HTA11_83_2000001011 | Human | Colorectum | SER | 3.14e-07 | 7.54e-01 | -0.1526 |
54458 | PRR13 | HTA11_696_2000001011 | Human | Colorectum | AD | 8.93e-21 | 8.28e-01 | -0.1464 |
54458 | PRR13 | HTA11_866_2000001011 | Human | Colorectum | AD | 6.54e-04 | 3.66e-01 | -0.1001 |
54458 | PRR13 | HTA11_1391_2000001011 | Human | Colorectum | AD | 4.15e-23 | 9.34e-01 | -0.059 |
54458 | PRR13 | HTA11_2992_2000001011 | Human | Colorectum | SER | 9.82e-14 | 1.24e+00 | -0.1706 |
54458 | PRR13 | HTA11_5212_2000001011 | Human | Colorectum | AD | 6.51e-13 | 1.02e+00 | -0.2061 |
54458 | PRR13 | HTA11_5216_2000001011 | Human | Colorectum | SER | 6.78e-06 | 8.46e-01 | -0.1462 |
54458 | PRR13 | HTA11_866_3004761011 | Human | Colorectum | AD | 8.48e-11 | 5.18e-01 | 0.096 |
54458 | PRR13 | HTA11_4255_2000001011 | Human | Colorectum | SER | 2.60e-02 | 3.31e-01 | 0.0446 |
54458 | PRR13 | HTA11_7663_2000001011 | Human | Colorectum | SER | 2.49e-05 | 6.66e-01 | 0.0131 |
54458 | PRR13 | HTA11_10623_2000001011 | Human | Colorectum | AD | 2.16e-03 | 5.05e-01 | -0.0177 |
54458 | PRR13 | HTA11_6801_2000001011 | Human | Colorectum | SER | 1.29e-12 | 1.20e+00 | 0.0171 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PRR13 | SNV | Missense_Mutation | c.428N>T | p.Ser143Phe | p.S143F | Q9NZ81 | protein_coding | tolerated_low_confidence(0.72) | probably_damaging(0.997) | TCGA-LP-A4AV-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
PRR13 | SNV | Missense_Mutation | novel | c.149G>T | p.Gly50Val | p.G50V | Q9NZ81 | protein_coding | deleterious_low_confidence(0.03) | possibly_damaging(0.833) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PRR13 | SNV | Missense_Mutation | novel | c.321G>T | p.Lys107Asn | p.K107N | Q9NZ81 | protein_coding | deleterious_low_confidence(0.01) | probably_damaging(0.998) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD |
PRR13 | SNV | Missense_Mutation | rs775012346 | c.248N>T | p.Pro83Leu | p.P83L | Q9NZ81 | protein_coding | deleterious_low_confidence(0.01) | probably_damaging(0.998) | TCGA-BG-A222-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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