![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: PRPSAP1 |
Gene summary for PRPSAP1 |
![]() |
Gene information | Species | Human | Gene symbol | PRPSAP1 | Gene ID | 5635 |
Gene name | phosphoribosyl pyrophosphate synthetase associated protein 1 | |
Gene Alias | PAP39 | |
Cytomap | 17q25.1 | |
Gene Type | protein-coding | GO ID | GO:0006015 | UniProtAcc | B4DP31 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
5635 | PRPSAP1 | LZE4T | Human | Esophagus | ESCC | 6.98e-08 | 3.88e-01 | 0.0811 |
5635 | PRPSAP1 | LZE7T | Human | Esophagus | ESCC | 3.09e-08 | 3.37e-01 | 0.0667 |
5635 | PRPSAP1 | LZE24T | Human | Esophagus | ESCC | 3.46e-16 | 5.20e-01 | 0.0596 |
5635 | PRPSAP1 | LZE21T | Human | Esophagus | ESCC | 9.87e-05 | 5.63e-01 | 0.0655 |
5635 | PRPSAP1 | P1T-E | Human | Esophagus | ESCC | 6.25e-08 | 5.34e-01 | 0.0875 |
5635 | PRPSAP1 | P2T-E | Human | Esophagus | ESCC | 8.00e-49 | 8.84e-01 | 0.1177 |
5635 | PRPSAP1 | P4T-E | Human | Esophagus | ESCC | 1.96e-25 | 6.16e-01 | 0.1323 |
5635 | PRPSAP1 | P5T-E | Human | Esophagus | ESCC | 2.49e-16 | 2.77e-01 | 0.1327 |
5635 | PRPSAP1 | P8T-E | Human | Esophagus | ESCC | 7.54e-31 | 5.91e-01 | 0.0889 |
5635 | PRPSAP1 | P9T-E | Human | Esophagus | ESCC | 2.83e-19 | 5.67e-01 | 0.1131 |
5635 | PRPSAP1 | P10T-E | Human | Esophagus | ESCC | 3.46e-42 | 7.46e-01 | 0.116 |
5635 | PRPSAP1 | P11T-E | Human | Esophagus | ESCC | 3.77e-26 | 8.36e-01 | 0.1426 |
5635 | PRPSAP1 | P12T-E | Human | Esophagus | ESCC | 2.32e-39 | 8.49e-01 | 0.1122 |
5635 | PRPSAP1 | P15T-E | Human | Esophagus | ESCC | 6.27e-38 | 1.06e+00 | 0.1149 |
5635 | PRPSAP1 | P16T-E | Human | Esophagus | ESCC | 2.35e-64 | 1.31e+00 | 0.1153 |
5635 | PRPSAP1 | P17T-E | Human | Esophagus | ESCC | 3.67e-05 | 5.40e-01 | 0.1278 |
5635 | PRPSAP1 | P19T-E | Human | Esophagus | ESCC | 1.13e-04 | 5.04e-01 | 0.1662 |
5635 | PRPSAP1 | P20T-E | Human | Esophagus | ESCC | 3.38e-59 | 1.54e+00 | 0.1124 |
5635 | PRPSAP1 | P21T-E | Human | Esophagus | ESCC | 2.50e-37 | 7.36e-01 | 0.1617 |
5635 | PRPSAP1 | P22T-E | Human | Esophagus | ESCC | 7.09e-37 | 5.76e-01 | 0.1236 |
Page: 1 2 3 4 5 6 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0006753110 | Esophagus | ESCC | nucleoside phosphate metabolic process | 288/8552 | 497/18723 | 1.80e-08 | 3.50e-07 | 288 |
GO:0019693111 | Esophagus | ESCC | ribose phosphate metabolic process | 234/8552 | 396/18723 | 4.24e-08 | 7.76e-07 | 234 |
GO:0009117111 | Esophagus | ESCC | nucleotide metabolic process | 282/8552 | 489/18723 | 4.70e-08 | 8.50e-07 | 282 |
GO:0072521111 | Esophagus | ESCC | purine-containing compound metabolic process | 238/8552 | 416/18723 | 1.20e-06 | 1.49e-05 | 238 |
GO:0046390110 | Esophagus | ESCC | ribose phosphate biosynthetic process | 119/8552 | 190/18723 | 1.73e-06 | 2.06e-05 | 119 |
GO:0006163111 | Esophagus | ESCC | purine nucleotide metabolic process | 226/8552 | 396/18723 | 2.81e-06 | 3.21e-05 | 226 |
GO:000916516 | Esophagus | ESCC | nucleotide biosynthetic process | 150/8552 | 254/18723 | 1.12e-05 | 1.06e-04 | 150 |
GO:190129316 | Esophagus | ESCC | nucleoside phosphate biosynthetic process | 151/8552 | 256/18723 | 1.15e-05 | 1.08e-04 | 151 |
GO:007252217 | Esophagus | ESCC | purine-containing compound biosynthetic process | 120/8552 | 200/18723 | 3.02e-05 | 2.51e-04 | 120 |
GO:000616417 | Esophagus | ESCC | purine nucleotide biosynthetic process | 113/8552 | 191/18723 | 1.16e-04 | 8.04e-04 | 113 |
GO:000675312 | Liver | Cirrhotic | nucleoside phosphate metabolic process | 190/4634 | 497/18723 | 1.10e-11 | 6.96e-10 | 190 |
GO:000911712 | Liver | Cirrhotic | nucleotide metabolic process | 187/4634 | 489/18723 | 1.55e-11 | 9.63e-10 | 187 |
GO:001969312 | Liver | Cirrhotic | ribose phosphate metabolic process | 156/4634 | 396/18723 | 5.83e-11 | 3.23e-09 | 156 |
GO:007252112 | Liver | Cirrhotic | purine-containing compound metabolic process | 156/4634 | 416/18723 | 3.74e-09 | 1.52e-07 | 156 |
GO:000616312 | Liver | Cirrhotic | purine nucleotide metabolic process | 146/4634 | 396/18723 | 4.12e-08 | 1.34e-06 | 146 |
GO:00463905 | Liver | Cirrhotic | ribose phosphate biosynthetic process | 71/4634 | 190/18723 | 7.09e-05 | 7.98e-04 | 71 |
GO:00091654 | Liver | Cirrhotic | nucleotide biosynthetic process | 89/4634 | 254/18723 | 1.45e-04 | 1.40e-03 | 89 |
GO:19012934 | Liver | Cirrhotic | nucleoside phosphate biosynthetic process | 89/4634 | 256/18723 | 1.97e-04 | 1.82e-03 | 89 |
GO:00725225 | Liver | Cirrhotic | purine-containing compound biosynthetic process | 69/4634 | 200/18723 | 1.22e-03 | 8.24e-03 | 69 |
GO:00061645 | Liver | Cirrhotic | purine nucleotide biosynthetic process | 65/4634 | 191/18723 | 2.42e-03 | 1.46e-02 | 65 |
Page: 1 2 3 4 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PRPSAP1 | SNV | Missense_Mutation | rs375906385 | c.662N>A | p.Arg221His | p.R221H | Q14558 | protein_coding | tolerated(0.09) | benign(0.233) | TCGA-C5-A7CJ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD |
PRPSAP1 | SNV | Missense_Mutation | rs756361339 | c.836N>A | p.Arg279His | p.R279H | Q14558 | protein_coding | tolerated(0.07) | benign(0.09) | TCGA-AA-3811-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
PRPSAP1 | SNV | Missense_Mutation | c.589N>C | p.Tyr197His | p.Y197H | Q14558 | protein_coding | tolerated(0.07) | probably_damaging(0.978) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
PRPSAP1 | SNV | Missense_Mutation | c.253C>T | p.Arg85Cys | p.R85C | Q14558 | protein_coding | deleterious(0) | probably_damaging(0.979) | TCGA-AA-A01R-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5-fluorouracil | PD | |
PRPSAP1 | SNV | Missense_Mutation | novel | c.362N>C | p.Ile121Thr | p.I121T | Q14558 | protein_coding | deleterious(0.01) | benign(0.382) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
PRPSAP1 | SNV | Missense_Mutation | c.829N>A | p.Gly277Arg | p.G277R | Q14558 | protein_coding | tolerated(0.21) | benign(0.249) | TCGA-AF-2693-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
PRPSAP1 | SNV | Missense_Mutation | rs375906385 | c.662N>A | p.Arg221His | p.R221H | Q14558 | protein_coding | tolerated(0.09) | benign(0.233) | TCGA-AH-6544-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | SD |
PRPSAP1 | insertion | Frame_Shift_Ins | novel | c.735_736insGGGG | p.Pro246GlyfsTer42 | p.P246Gfs*42 | Q14558 | protein_coding | TCGA-T9-A92H-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | ||
PRPSAP1 | SNV | Missense_Mutation | novel | c.493C>A | p.His165Asn | p.H165N | Q14558 | protein_coding | deleterious(0) | possibly_damaging(0.837) | TCGA-AJ-A23O-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PRPSAP1 | SNV | Missense_Mutation | novel | c.916G>A | p.Ala306Thr | p.A306T | Q14558 | protein_coding | deleterious(0) | probably_damaging(0.991) | TCGA-AJ-A3OK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | CR |
Page: 1 2 3 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |