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Gene: PRC1 |
Gene summary for PRC1 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | PRC1 | Gene ID | 9055 |
| Gene name | protein regulator of cytokinesis 1 | |
| Gene Alias | ASE1 | |
| Cytomap | 15q26.1 | |
| Gene Type | protein-coding | GO ID | GO:0000022 | UniProtAcc | O43663 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 9055 | PRC1 | LZE2T | Human | Esophagus | ESCC | 3.37e-05 | 9.45e-01 | 0.082 |
| 9055 | PRC1 | LZE4T | Human | Esophagus | ESCC | 9.84e-05 | 2.88e-01 | 0.0811 |
| 9055 | PRC1 | LZE7T | Human | Esophagus | ESCC | 8.44e-05 | 3.95e-01 | 0.0667 |
| 9055 | PRC1 | LZE21T | Human | Esophagus | ESCC | 7.59e-03 | 4.89e-01 | 0.0655 |
| 9055 | PRC1 | LZE6T | Human | Esophagus | ESCC | 1.01e-02 | 2.76e-01 | 0.0845 |
| 9055 | PRC1 | P1T-E | Human | Esophagus | ESCC | 2.21e-04 | 6.22e-01 | 0.0875 |
| 9055 | PRC1 | P2T-E | Human | Esophagus | ESCC | 1.35e-23 | 6.49e-01 | 0.1177 |
| 9055 | PRC1 | P4T-E | Human | Esophagus | ESCC | 2.99e-19 | 7.03e-01 | 0.1323 |
| 9055 | PRC1 | P5T-E | Human | Esophagus | ESCC | 3.58e-28 | 6.76e-01 | 0.1327 |
| 9055 | PRC1 | P8T-E | Human | Esophagus | ESCC | 8.40e-04 | 1.97e-01 | 0.0889 |
| 9055 | PRC1 | P9T-E | Human | Esophagus | ESCC | 1.78e-12 | 5.27e-01 | 0.1131 |
| 9055 | PRC1 | P10T-E | Human | Esophagus | ESCC | 2.27e-21 | 9.93e-01 | 0.116 |
| 9055 | PRC1 | P12T-E | Human | Esophagus | ESCC | 4.41e-07 | 1.80e-01 | 0.1122 |
| 9055 | PRC1 | P15T-E | Human | Esophagus | ESCC | 7.50e-08 | 4.18e-01 | 0.1149 |
| 9055 | PRC1 | P16T-E | Human | Esophagus | ESCC | 8.56e-12 | 3.49e-01 | 0.1153 |
| 9055 | PRC1 | P17T-E | Human | Esophagus | ESCC | 1.57e-03 | 5.77e-01 | 0.1278 |
| 9055 | PRC1 | P19T-E | Human | Esophagus | ESCC | 3.31e-02 | 7.24e-01 | 0.1662 |
| 9055 | PRC1 | P20T-E | Human | Esophagus | ESCC | 4.65e-09 | 3.21e-01 | 0.1124 |
| 9055 | PRC1 | P21T-E | Human | Esophagus | ESCC | 7.37e-11 | 4.29e-01 | 0.1617 |
| 9055 | PRC1 | P22T-E | Human | Esophagus | ESCC | 1.76e-12 | 3.97e-01 | 0.1236 |
| Page: 1 2 3 4 5 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma | ||
| Skin |  | AK: Actinic keratosis |
| cSCC: Cutaneous squamous cell carcinoma | ||
| SCCIS:squamous cell carcinoma in situ | ||
| Thyroid |  | ATC: Anaplastic thyroid cancer |
| HT: Hashimoto's thyroiditis | ||
| PTC: Papillary thyroid cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:014001414 | Esophagus | ESCC | mitotic nuclear division | 218/8552 | 287/18723 | 6.17e-26 | 1.78e-23 | 218 |
| GO:000007011 | Esophagus | ESCC | mitotic sister chromatid segregation | 138/8552 | 168/18723 | 1.37e-22 | 2.63e-20 | 138 |
| GO:00008194 | Esophagus | ESCC | sister chromatid segregation | 157/8552 | 202/18723 | 8.41e-21 | 1.33e-18 | 157 |
| GO:000705911 | Esophagus | ESCC | chromosome segregation | 238/8552 | 346/18723 | 1.72e-18 | 1.82e-16 | 238 |
| GO:190285015 | Esophagus | ESCC | microtubule cytoskeleton organization involved in mitosis | 116/8552 | 147/18723 | 1.25e-16 | 9.91e-15 | 116 |
| GO:000705214 | Esophagus | ESCC | mitotic spindle organization | 97/8552 | 120/18723 | 2.17e-15 | 1.33e-13 | 97 |
| GO:000705114 | Esophagus | ESCC | spindle organization | 134/8552 | 184/18723 | 5.70e-14 | 2.87e-12 | 134 |
| GO:00482853 | Esophagus | ESCC | organelle fission | 301/8552 | 488/18723 | 4.64e-13 | 2.12e-11 | 301 |
| GO:00988133 | Esophagus | ESCC | nuclear chromosome segregation | 187/8552 | 281/18723 | 1.00e-12 | 4.36e-11 | 187 |
| GO:00002802 | Esophagus | ESCC | nuclear division | 270/8552 | 439/18723 | 1.17e-11 | 4.24e-10 | 270 |
| GO:00512256 | Esophagus | ESCC | spindle assembly | 85/8552 | 117/18723 | 2.72e-09 | 5.98e-08 | 85 |
| GO:009030715 | Esophagus | ESCC | mitotic spindle assembly | 52/8552 | 65/18723 | 1.41e-08 | 2.77e-07 | 52 |
| GO:000091016 | Esophagus | ESCC | cytokinesis | 115/8552 | 173/18723 | 2.48e-08 | 4.68e-07 | 115 |
| GO:00510908 | Esophagus | ESCC | regulation of DNA-binding transcription factor activity | 252/8552 | 440/18723 | 5.22e-07 | 6.97e-06 | 252 |
| GO:00510918 | Esophagus | ESCC | positive regulation of DNA-binding transcription factor activity | 155/8552 | 260/18723 | 3.83e-06 | 4.14e-05 | 155 |
| GO:00324653 | Esophagus | ESCC | regulation of cytokinesis | 57/8552 | 92/18723 | 1.20e-03 | 5.88e-03 | 57 |
| GO:00513025 | Esophagus | ESCC | regulation of cell division | 97/8552 | 177/18723 | 8.93e-03 | 3.12e-02 | 97 |
| GO:014001411 | Liver | HCC | mitotic nuclear division | 174/7958 | 287/18723 | 3.74e-10 | 1.23e-08 | 174 |
| GO:0000070 | Liver | HCC | mitotic sister chromatid segregation | 110/7958 | 168/18723 | 1.42e-09 | 4.25e-08 | 110 |
| GO:00008191 | Liver | HCC | sister chromatid segregation | 128/7958 | 202/18723 | 1.59e-09 | 4.73e-08 | 128 |
| Page: 1 2 3 4 5 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| PRC1 | SNV | Missense_Mutation | c.589N>A | p.Glu197Lys | p.E197K | O43663 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-A2-A0CR-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | CR | |
| PRC1 | SNV | Missense_Mutation | c.1300N>C | p.Glu434Gln | p.E434Q | O43663 | protein_coding | tolerated(0.21) | benign(0.095) | TCGA-A8-A0A7-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
| PRC1 | SNV | Missense_Mutation | c.607N>A | p.Glu203Lys | p.E203K | O43663 | protein_coding | deleterious(0.02) | probably_damaging(0.988) | TCGA-D8-A1JA-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | PD | |
| PRC1 | SNV | Missense_Mutation | c.404N>C | p.Leu135Pro | p.L135P | O43663 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-E9-A1R4-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | 5-fluorouracil | SD | |
| PRC1 | insertion | Frame_Shift_Ins | novel | c.58_59insCACTCTGTGCAGCGAGTTAC | p.Asn20ThrfsTer16 | p.N20Tfs*16 | O43663 | protein_coding | TCGA-A8-A09T-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | anastrozole | SD | ||
| PRC1 | insertion | Frame_Shift_Ins | novel | c.59_60insGTCTCGCTGTGTTGTCCAGGCAGGAGTGCAATGGTGTGGTCTC | p.Asn20LysfsTer36 | p.N20Kfs*36 | O43663 | protein_coding | TCGA-BH-A0B8-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | arimidex | SD | ||
| PRC1 | deletion | Frame_Shift_Del | novel | c.1155delN | p.Leu386Ter | p.L386* | O43663 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
| PRC1 | SNV | Missense_Mutation | c.1068G>C | p.Gln356His | p.Q356H | O43663 | protein_coding | tolerated(0.29) | benign(0.021) | TCGA-C5-A1BQ-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Chemotherapy | cisplatin | CR | |
| PRC1 | SNV | Missense_Mutation | c.94N>T | p.Pro32Ser | p.P32S | O43663 | protein_coding | deleterious(0.02) | possibly_damaging(0.574) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
| PRC1 | SNV | Missense_Mutation | rs573547983 | c.511C>T | p.Arg171Cys | p.R171C | O43663 | protein_coding | deleterious(0.01) | possibly_damaging(0.601) | TCGA-G4-6628-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
| Page: 1 2 3 4 5 6 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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