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Gene: PRAP1 |
Gene summary for PRAP1 |
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Gene information | Species | Human | Gene symbol | PRAP1 | Gene ID | 118471 |
Gene name | proline rich acidic protein 1 | |
Gene Alias | PRO1195 | |
Cytomap | 10q26.3 | |
Gene Type | protein-coding | GO ID | GO:0000070 | UniProtAcc | A6XND8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
118471 | PRAP1 | HTA11_2487_2000001011 | Human | Colorectum | SER | 7.88e-06 | 4.03e-01 | -0.1808 |
118471 | PRAP1 | HTA11_1938_2000001011 | Human | Colorectum | AD | 7.86e-07 | 3.42e-01 | -0.0811 |
118471 | PRAP1 | HTA11_3361_2000001011 | Human | Colorectum | AD | 1.05e-04 | 3.21e-01 | -0.1207 |
118471 | PRAP1 | HTA11_1391_2000001011 | Human | Colorectum | AD | 7.80e-09 | 3.86e-01 | -0.059 |
118471 | PRAP1 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 5.16e-04 | 1.69e-01 | 0.3005 |
118471 | PRAP1 | S42 | Human | Liver | HCC | 8.03e-05 | 9.58e-01 | -0.0103 |
118471 | PRAP1 | HCC1_Meng | Human | Liver | HCC | 6.10e-121 | 1.27e+00 | 0.0246 |
118471 | PRAP1 | cirrhotic3 | Human | Liver | Cirrhotic | 1.48e-05 | 2.15e-01 | 0.0215 |
118471 | PRAP1 | HCC1 | Human | Liver | HCC | 3.01e-19 | 3.48e+00 | 0.5336 |
118471 | PRAP1 | HCC2 | Human | Liver | HCC | 3.50e-51 | 4.09e+00 | 0.5341 |
118471 | PRAP1 | HCC5 | Human | Liver | HCC | 4.17e-05 | 1.66e+00 | 0.4932 |
118471 | PRAP1 | Pt13.a | Human | Liver | HCC | 1.40e-24 | 5.26e-01 | 0.021 |
118471 | PRAP1 | Pt13.b | Human | Liver | HCC | 3.76e-48 | 6.15e-01 | 0.0251 |
118471 | PRAP1 | Pt13.c | Human | Liver | HCC | 1.30e-06 | 4.38e-01 | 0.0076 |
118471 | PRAP1 | Pt14.a | Human | Liver | HCC | 2.22e-06 | 2.56e-01 | 0.0169 |
118471 | PRAP1 | Pt14.b | Human | Liver | HCC | 1.85e-21 | 6.37e-01 | 0.018 |
118471 | PRAP1 | Pt14.d | Human | Liver | HCC | 2.45e-20 | 5.20e-01 | 0.0143 |
118471 | PRAP1 | S014 | Human | Liver | HCC | 4.59e-46 | 1.60e+00 | 0.2254 |
118471 | PRAP1 | S015 | Human | Liver | HCC | 1.17e-46 | 2.12e+00 | 0.2375 |
118471 | PRAP1 | S016 | Human | Liver | HCC | 6.59e-56 | 1.90e+00 | 0.2243 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0010639 | Colorectum | AD | negative regulation of organelle organization | 114/3918 | 348/18723 | 1.41e-07 | 6.49e-06 | 114 |
GO:2001252 | Colorectum | AD | positive regulation of chromosome organization | 35/3918 | 82/18723 | 6.90e-06 | 1.72e-04 | 35 |
GO:0072331 | Colorectum | AD | signal transduction by p53 class mediator | 58/3918 | 163/18723 | 1.04e-05 | 2.40e-04 | 58 |
GO:0033044 | Colorectum | AD | regulation of chromosome organization | 60/3918 | 187/18723 | 2.25e-04 | 2.94e-03 | 60 |
GO:0010876 | Colorectum | AD | lipid localization | 120/3918 | 448/18723 | 1.59e-03 | 1.33e-02 | 120 |
GO:0006869 | Colorectum | AD | lipid transport | 108/3918 | 398/18723 | 1.67e-03 | 1.39e-02 | 108 |
GO:0071481 | Colorectum | AD | cellular response to X-ray | 8/3918 | 14/18723 | 3.23e-03 | 2.38e-02 | 8 |
GO:0007346 | Colorectum | AD | regulation of mitotic cell cycle | 119/3918 | 457/18723 | 4.60e-03 | 3.14e-02 | 119 |
GO:0030330 | Colorectum | AD | DNA damage response, signal transduction by p53 class mediator | 25/3918 | 72/18723 | 4.65e-03 | 3.16e-02 | 25 |
GO:0045787 | Colorectum | AD | positive regulation of cell cycle | 85/3918 | 313/18723 | 4.76e-03 | 3.22e-02 | 85 |
GO:0045842 | Colorectum | AD | positive regulation of mitotic metaphase/anaphase transition | 8/3918 | 15/18723 | 5.67e-03 | 3.64e-02 | 8 |
GO:1901970 | Colorectum | AD | positive regulation of mitotic sister chromatid separation | 8/3918 | 15/18723 | 5.67e-03 | 3.64e-02 | 8 |
GO:1905820 | Colorectum | AD | positive regulation of chromosome separation | 9/3918 | 18/18723 | 5.82e-03 | 3.67e-02 | 9 |
GO:0140014 | Colorectum | AD | mitotic nuclear division | 78/3918 | 287/18723 | 6.48e-03 | 4.05e-02 | 78 |
GO:0015748 | Colorectum | AD | organophosphate ester transport | 42/3918 | 140/18723 | 7.04e-03 | 4.31e-02 | 42 |
GO:0045931 | Colorectum | AD | positive regulation of mitotic cell cycle | 37/3918 | 121/18723 | 7.88e-03 | 4.73e-02 | 37 |
GO:00106391 | Colorectum | SER | negative regulation of organelle organization | 90/2897 | 348/18723 | 3.14e-07 | 1.69e-05 | 90 |
GO:20012521 | Colorectum | SER | positive regulation of chromosome organization | 27/2897 | 82/18723 | 6.44e-05 | 1.49e-03 | 27 |
GO:00723311 | Colorectum | SER | signal transduction by p53 class mediator | 43/2897 | 163/18723 | 2.22e-04 | 3.90e-03 | 43 |
GO:0022600 | Colorectum | SER | digestive system process | 29/2897 | 104/18723 | 8.57e-04 | 1.05e-02 | 29 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa04140 | Colorectum | AD | Autophagy - animal | 49/2092 | 141/8465 | 4.58e-03 | 2.20e-02 | 1.40e-02 | 49 |
hsa041401 | Colorectum | AD | Autophagy - animal | 49/2092 | 141/8465 | 4.58e-03 | 2.20e-02 | 1.40e-02 | 49 |
hsa041402 | Colorectum | SER | Autophagy - animal | 39/1580 | 141/8465 | 5.43e-03 | 3.28e-02 | 2.38e-02 | 39 |
hsa041403 | Colorectum | SER | Autophagy - animal | 39/1580 | 141/8465 | 5.43e-03 | 3.28e-02 | 2.38e-02 | 39 |
hsa041404 | Colorectum | MSS | Autophagy - animal | 45/1875 | 141/8465 | 4.42e-03 | 1.90e-02 | 1.16e-02 | 45 |
hsa041405 | Colorectum | MSS | Autophagy - animal | 45/1875 | 141/8465 | 4.42e-03 | 1.90e-02 | 1.16e-02 | 45 |
hsa041406 | Liver | Cirrhotic | Autophagy - animal | 65/2530 | 141/8465 | 3.10e-05 | 2.47e-04 | 1.52e-04 | 65 |
hsa0414011 | Liver | Cirrhotic | Autophagy - animal | 65/2530 | 141/8465 | 3.10e-05 | 2.47e-04 | 1.52e-04 | 65 |
hsa0414021 | Liver | HCC | Autophagy - animal | 99/4020 | 141/8465 | 3.08e-08 | 4.70e-07 | 2.61e-07 | 99 |
hsa0414031 | Liver | HCC | Autophagy - animal | 99/4020 | 141/8465 | 3.08e-08 | 4.70e-07 | 2.61e-07 | 99 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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