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Gene: PRAF2 |
Gene summary for PRAF2 |
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Gene information | Species | Human | Gene symbol | PRAF2 | Gene ID | 11230 |
Gene name | PRA1 domain family member 2 | |
Gene Alias | JM4 | |
Cytomap | Xp11.23 | |
Gene Type | protein-coding | GO ID | GO:0003333 | UniProtAcc | A0A024QZ22 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
11230 | PRAF2 | LZE4T | Human | Esophagus | ESCC | 5.67e-04 | 1.50e-01 | 0.0811 |
11230 | PRAF2 | LZE7T | Human | Esophagus | ESCC | 1.25e-04 | 2.45e-01 | 0.0667 |
11230 | PRAF2 | LZE24T | Human | Esophagus | ESCC | 6.84e-07 | 9.83e-02 | 0.0596 |
11230 | PRAF2 | P2T-E | Human | Esophagus | ESCC | 9.26e-13 | 2.03e-01 | 0.1177 |
11230 | PRAF2 | P4T-E | Human | Esophagus | ESCC | 2.64e-09 | 2.01e-01 | 0.1323 |
11230 | PRAF2 | P5T-E | Human | Esophagus | ESCC | 1.81e-05 | 4.77e-02 | 0.1327 |
11230 | PRAF2 | P8T-E | Human | Esophagus | ESCC | 1.27e-04 | 5.61e-02 | 0.0889 |
11230 | PRAF2 | P9T-E | Human | Esophagus | ESCC | 1.57e-11 | 3.18e-01 | 0.1131 |
11230 | PRAF2 | P10T-E | Human | Esophagus | ESCC | 2.22e-19 | 3.63e-01 | 0.116 |
11230 | PRAF2 | P11T-E | Human | Esophagus | ESCC | 2.12e-10 | 4.06e-01 | 0.1426 |
11230 | PRAF2 | P12T-E | Human | Esophagus | ESCC | 7.64e-17 | 1.93e-01 | 0.1122 |
11230 | PRAF2 | P15T-E | Human | Esophagus | ESCC | 1.67e-12 | 1.91e-01 | 0.1149 |
11230 | PRAF2 | P16T-E | Human | Esophagus | ESCC | 1.14e-20 | 3.53e-01 | 0.1153 |
11230 | PRAF2 | P20T-E | Human | Esophagus | ESCC | 1.20e-10 | 2.18e-01 | 0.1124 |
11230 | PRAF2 | P21T-E | Human | Esophagus | ESCC | 1.30e-07 | 2.13e-01 | 0.1617 |
11230 | PRAF2 | P22T-E | Human | Esophagus | ESCC | 9.10e-31 | 5.65e-01 | 0.1236 |
11230 | PRAF2 | P23T-E | Human | Esophagus | ESCC | 4.49e-09 | 2.45e-01 | 0.108 |
11230 | PRAF2 | P24T-E | Human | Esophagus | ESCC | 2.67e-12 | 1.38e-01 | 0.1287 |
11230 | PRAF2 | P26T-E | Human | Esophagus | ESCC | 2.07e-27 | 4.47e-01 | 0.1276 |
11230 | PRAF2 | P27T-E | Human | Esophagus | ESCC | 5.41e-13 | 3.39e-01 | 0.1055 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PRAF2 | SNV | Missense_Mutation | novel | c.9N>T | p.Glu3Asp | p.E3D | O60831 | protein_coding | tolerated(1) | benign(0.031) | TCGA-BI-A20A-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
PRAF2 | SNV | Missense_Mutation | c.58N>A | p.Ala20Thr | p.A20T | O60831 | protein_coding | tolerated(0.33) | benign(0.093) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
PRAF2 | SNV | Missense_Mutation | novel | c.40N>A | p.Asp14Asn | p.D14N | O60831 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AJ-A3EL-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PRAF2 | SNV | Missense_Mutation | c.109N>A | p.Val37Ile | p.V37I | O60831 | protein_coding | tolerated(0.27) | benign(0.133) | TCGA-D1-A1NZ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
PRAF2 | SNV | Missense_Mutation | novel | c.40N>A | p.Asp14Asn | p.D14N | O60831 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-EY-A1G8-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PRAF2 | SNV | Missense_Mutation | c.59N>T | p.Ala20Val | p.A20V | O60831 | protein_coding | tolerated(0.12) | possibly_damaging(0.49) | TCGA-BR-6566-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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