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Gene: PQLC1 |
Gene summary for PQLC1 |
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Gene information | Species | Human | Gene symbol | PQLC1 | Gene ID | 80148 |
Gene name | solute carrier family 66 member 2 | |
Gene Alias | PQLC1 | |
Cytomap | 18q23 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | Q8N2U9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
80148 | PQLC1 | NAFLD1 | Human | Liver | NAFLD | 5.35e-08 | 7.85e-01 | -0.04 |
80148 | PQLC1 | S43 | Human | Liver | Cirrhotic | 1.05e-05 | -1.51e-01 | -0.0187 |
80148 | PQLC1 | HCC1_Meng | Human | Liver | HCC | 6.42e-63 | 6.07e-02 | 0.0246 |
80148 | PQLC1 | HCC2_Meng | Human | Liver | HCC | 4.03e-07 | -6.01e-02 | 0.0107 |
80148 | PQLC1 | HCC2 | Human | Liver | HCC | 3.97e-03 | 2.89e+00 | 0.5341 |
80148 | PQLC1 | Pt14.a | Human | Liver | HCC | 1.66e-02 | 2.98e-01 | 0.0169 |
80148 | PQLC1 | Pt14.b | Human | Liver | HCC | 3.50e-03 | 2.58e-01 | 0.018 |
80148 | PQLC1 | S014 | Human | Liver | HCC | 3.72e-04 | 3.75e-01 | 0.2254 |
80148 | PQLC1 | S015 | Human | Liver | HCC | 9.18e-12 | 7.03e-01 | 0.2375 |
80148 | PQLC1 | S016 | Human | Liver | HCC | 8.56e-05 | 3.24e-01 | 0.2243 |
80148 | PQLC1 | S027 | Human | Liver | HCC | 9.85e-03 | 4.84e-01 | 0.2446 |
80148 | PQLC1 | S028 | Human | Liver | HCC | 6.49e-17 | 7.09e-01 | 0.2503 |
80148 | PQLC1 | S029 | Human | Liver | HCC | 3.55e-15 | 7.16e-01 | 0.2581 |
80148 | PQLC1 | C04 | Human | Oral cavity | OSCC | 4.93e-20 | 7.82e-01 | 0.2633 |
80148 | PQLC1 | C21 | Human | Oral cavity | OSCC | 4.79e-18 | 6.02e-01 | 0.2678 |
80148 | PQLC1 | C30 | Human | Oral cavity | OSCC | 2.54e-45 | 1.72e+00 | 0.3055 |
80148 | PQLC1 | C38 | Human | Oral cavity | OSCC | 2.31e-08 | 8.23e-01 | 0.172 |
80148 | PQLC1 | C43 | Human | Oral cavity | OSCC | 2.87e-07 | 1.83e-01 | 0.1704 |
80148 | PQLC1 | C46 | Human | Oral cavity | OSCC | 2.28e-11 | 3.69e-01 | 0.1673 |
80148 | PQLC1 | C51 | Human | Oral cavity | OSCC | 5.71e-03 | 2.64e-01 | 0.2674 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PQLC1 | SNV | Missense_Mutation | c.677N>T | p.Ala226Val | p.A226V | Q8N2U9 | protein_coding | tolerated(0.06) | benign(0.134) | TCGA-AD-6964-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | folfox | PD | |
PQLC1 | SNV | Missense_Mutation | c.547N>T | p.Ala183Ser | p.A183S | Q8N2U9 | protein_coding | deleterious(0) | possibly_damaging(0.666) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
PQLC1 | SNV | Missense_Mutation | c.224N>T | p.Ser75Phe | p.S75F | Q8N2U9 | protein_coding | tolerated(0.43) | benign(0.312) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
PQLC1 | SNV | Missense_Mutation | novel | c.125N>T | p.Arg42Met | p.R42M | Q8N2U9 | protein_coding | deleterious(0) | probably_damaging(0.979) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PQLC1 | SNV | Missense_Mutation | c.359N>T | p.Glu120Val | p.E120V | Q8N2U9 | protein_coding | tolerated(0.13) | probably_damaging(0.915) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
PQLC1 | SNV | Missense_Mutation | rs760068053 | c.575N>A | p.Arg192His | p.R192H | Q8N2U9 | protein_coding | deleterious(0.03) | benign(0.104) | TCGA-AX-A2HD-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
PQLC1 | SNV | Missense_Mutation | novel | c.134N>G | p.Asn45Ser | p.N45S | Q8N2U9 | protein_coding | deleterious(0.04) | benign(0.078) | TCGA-AX-A2HJ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PQLC1 | SNV | Missense_Mutation | rs150340109 | c.470C>T | p.Ala157Val | p.A157V | Q8N2U9 | protein_coding | tolerated(0.12) | benign(0.001) | TCGA-B5-A1MR-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
PQLC1 | SNV | Missense_Mutation | rs748167009 | c.397N>A | p.Asp133Asn | p.D133N | Q8N2U9 | protein_coding | tolerated(0.12) | possibly_damaging(0.865) | TCGA-D1-A16Y-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PQLC1 | SNV | Missense_Mutation | rs748167009 | c.397N>A | p.Asp133Asn | p.D133N | Q8N2U9 | protein_coding | tolerated(0.12) | possibly_damaging(0.865) | TCGA-E6-A1LX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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