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Gene: PPTC7 |
Gene summary for PPTC7 |
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Gene information | Species | Human | Gene symbol | PPTC7 | Gene ID | 160760 |
Gene name | protein phosphatase targeting COQ7 | |
Gene Alias | TA-PP2C | |
Cytomap | 12q24.11 | |
Gene Type | protein-coding | GO ID | GO:0006464 | UniProtAcc | Q8NI37 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
160760 | PPTC7 | LZE4T | Human | Esophagus | ESCC | 9.05e-04 | -2.19e-01 | 0.0811 |
160760 | PPTC7 | LZE8T | Human | Esophagus | ESCC | 2.26e-05 | 7.97e-03 | 0.067 |
160760 | PPTC7 | LZE20T | Human | Esophagus | ESCC | 1.90e-06 | -1.22e-01 | 0.0662 |
160760 | PPTC7 | LZE24T | Human | Esophagus | ESCC | 4.86e-06 | -4.03e-02 | 0.0596 |
160760 | PPTC7 | LZE21T | Human | Esophagus | ESCC | 1.56e-02 | -1.37e-01 | 0.0655 |
160760 | PPTC7 | P1T-E | Human | Esophagus | ESCC | 6.07e-03 | -2.36e-02 | 0.0875 |
160760 | PPTC7 | P2T-E | Human | Esophagus | ESCC | 2.15e-20 | 3.02e-01 | 0.1177 |
160760 | PPTC7 | P4T-E | Human | Esophagus | ESCC | 1.08e-20 | 3.01e-01 | 0.1323 |
160760 | PPTC7 | P5T-E | Human | Esophagus | ESCC | 8.90e-18 | 4.40e-01 | 0.1327 |
160760 | PPTC7 | P8T-E | Human | Esophagus | ESCC | 1.02e-09 | 1.56e-02 | 0.0889 |
160760 | PPTC7 | P9T-E | Human | Esophagus | ESCC | 1.03e-11 | 8.29e-02 | 0.1131 |
160760 | PPTC7 | P10T-E | Human | Esophagus | ESCC | 1.10e-14 | -1.30e-01 | 0.116 |
160760 | PPTC7 | P11T-E | Human | Esophagus | ESCC | 3.88e-07 | 1.59e-01 | 0.1426 |
160760 | PPTC7 | P12T-E | Human | Esophagus | ESCC | 2.70e-10 | 6.46e-02 | 0.1122 |
160760 | PPTC7 | P15T-E | Human | Esophagus | ESCC | 3.44e-17 | 7.67e-02 | 0.1149 |
160760 | PPTC7 | P16T-E | Human | Esophagus | ESCC | 3.99e-11 | -9.97e-02 | 0.1153 |
160760 | PPTC7 | P17T-E | Human | Esophagus | ESCC | 2.66e-03 | -4.98e-02 | 0.1278 |
160760 | PPTC7 | P20T-E | Human | Esophagus | ESCC | 5.14e-14 | 1.49e-01 | 0.1124 |
160760 | PPTC7 | P21T-E | Human | Esophagus | ESCC | 1.01e-15 | 1.43e-01 | 0.1617 |
160760 | PPTC7 | P22T-E | Human | Esophagus | ESCC | 8.38e-06 | -1.21e-01 | 0.1236 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:001631110 | Esophagus | ESCC | dephosphorylation | 251/8552 | 417/18723 | 1.26e-09 | 2.99e-08 | 251 |
GO:000647018 | Esophagus | ESCC | protein dephosphorylation | 177/8552 | 281/18723 | 3.13e-09 | 6.72e-08 | 177 |
GO:190166112 | Esophagus | ESCC | quinone metabolic process | 34/8552 | 40/18723 | 3.00e-07 | 4.27e-06 | 34 |
GO:00067432 | Esophagus | ESCC | ubiquinone metabolic process | 17/8552 | 19/18723 | 9.02e-05 | 6.50e-04 | 17 |
GO:00620129 | Esophagus | ESCC | regulation of small molecule metabolic process | 184/8552 | 334/18723 | 3.11e-04 | 1.85e-03 | 184 |
GO:00067442 | Esophagus | ESCC | ubiquinone biosynthetic process | 15/8552 | 17/18723 | 3.48e-04 | 2.03e-03 | 15 |
GO:19016632 | Esophagus | ESCC | quinone biosynthetic process | 15/8552 | 17/18723 | 3.48e-04 | 2.03e-03 | 15 |
GO:00702624 | Esophagus | ESCC | peptidyl-serine dephosphorylation | 16/8552 | 19/18723 | 6.45e-04 | 3.43e-03 | 16 |
GO:00421805 | Esophagus | ESCC | cellular ketone metabolic process | 120/8552 | 211/18723 | 6.70e-04 | 3.55e-03 | 120 |
GO:000647015 | Oral cavity | OSCC | protein dephosphorylation | 162/7305 | 281/18723 | 1.56e-10 | 4.56e-09 | 162 |
GO:00163119 | Oral cavity | OSCC | dephosphorylation | 220/7305 | 417/18723 | 6.33e-09 | 1.34e-07 | 220 |
GO:19016613 | Oral cavity | OSCC | quinone metabolic process | 32/7305 | 40/18723 | 1.40e-07 | 2.34e-06 | 32 |
GO:00421804 | Oral cavity | OSCC | cellular ketone metabolic process | 111/7305 | 211/18723 | 3.94e-05 | 3.45e-04 | 111 |
GO:0006743 | Oral cavity | OSCC | ubiquinone metabolic process | 16/7305 | 19/18723 | 7.05e-05 | 5.60e-04 | 16 |
GO:00702623 | Oral cavity | OSCC | peptidyl-serine dephosphorylation | 16/7305 | 19/18723 | 7.05e-05 | 5.60e-04 | 16 |
GO:0006744 | Oral cavity | OSCC | ubiquinone biosynthetic process | 14/7305 | 17/18723 | 3.31e-04 | 2.04e-03 | 14 |
GO:1901663 | Oral cavity | OSCC | quinone biosynthetic process | 14/7305 | 17/18723 | 3.31e-04 | 2.04e-03 | 14 |
GO:00620128 | Oral cavity | OSCC | regulation of small molecule metabolic process | 155/7305 | 334/18723 | 3.30e-03 | 1.41e-02 | 155 |
GO:0042181 | Oral cavity | OSCC | ketone biosynthetic process | 26/7305 | 43/18723 | 3.55e-03 | 1.49e-02 | 26 |
GO:000647023 | Oral cavity | EOLP | protein dephosphorylation | 72/2218 | 281/18723 | 1.19e-10 | 1.35e-08 | 72 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PPTC7 | SNV | Missense_Mutation | novel | c.616N>A | p.Asp206Asn | p.D206N | Q8NI37 | protein_coding | tolerated(0.12) | benign(0.411) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
PPTC7 | SNV | Missense_Mutation | novel | c.746T>G | p.Ile249Arg | p.I249R | Q8NI37 | protein_coding | deleterious(0) | possibly_damaging(0.675) | TCGA-AC-A8OQ-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PPTC7 | SNV | Missense_Mutation | novel | c.515N>A | p.Arg172Gln | p.R172Q | Q8NI37 | protein_coding | deleterious(0.03) | possibly_damaging(0.532) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PPTC7 | SNV | Missense_Mutation | c.301T>C | p.Cys101Arg | p.C101R | Q8NI37 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-D8-A1XQ-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
PPTC7 | SNV | Missense_Mutation | novel | c.413N>T | p.Thr138Ile | p.T138I | Q8NI37 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-E9-A1N9-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD |
PPTC7 | SNV | Missense_Mutation | novel | c.274N>G | p.Gln92Glu | p.Q92E | Q8NI37 | protein_coding | tolerated(0.85) | benign(0.003) | TCGA-C5-A1BJ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
PPTC7 | SNV | Missense_Mutation | c.580G>A | p.Glu194Lys | p.E194K | Q8NI37 | protein_coding | tolerated(0.63) | benign(0.069) | TCGA-C5-A1M8-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
PPTC7 | SNV | Missense_Mutation | novel | c.699N>A | p.Met233Ile | p.M233I | Q8NI37 | protein_coding | tolerated(0.22) | benign(0.065) | TCGA-HM-A4S6-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | cisplatin | CR |
PPTC7 | SNV | Missense_Mutation | c.658N>G | p.Thr220Ala | p.T220A | Q8NI37 | protein_coding | tolerated(0.07) | benign(0.105) | TCGA-A6-6780-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
PPTC7 | SNV | Missense_Mutation | novel | c.565N>A | p.Ala189Thr | p.A189T | Q8NI37 | protein_coding | deleterious(0.02) | possibly_damaging(0.657) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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