Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: PPP2R5B

Gene summary for PPP2R5B

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

PPP2R5B

Gene ID

5526

Gene nameprotein phosphatase 2 regulatory subunit B'beta
Gene AliasB56B
Cytomap11q13.1
Gene Typeprotein-coding
GO ID

GO:0001932

UniProtAcc

A0A024R593


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
5526PPP2R5BLZE24THumanEsophagusESCC9.26e-072.42e-010.0596
5526PPP2R5BP1T-EHumanEsophagusESCC3.57e-022.05e-010.0875
5526PPP2R5BP2T-EHumanEsophagusESCC3.60e-047.85e-020.1177
5526PPP2R5BP4T-EHumanEsophagusESCC4.35e-132.80e-010.1323
5526PPP2R5BP5T-EHumanEsophagusESCC7.14e-111.19e-010.1327
5526PPP2R5BP8T-EHumanEsophagusESCC1.47e-131.57e-010.0889
5526PPP2R5BP9T-EHumanEsophagusESCC2.71e-031.32e-010.1131
5526PPP2R5BP10T-EHumanEsophagusESCC1.01e-041.39e-010.116
5526PPP2R5BP11T-EHumanEsophagusESCC1.62e-103.98e-010.1426
5526PPP2R5BP12T-EHumanEsophagusESCC1.88e-111.95e-010.1122
5526PPP2R5BP16T-EHumanEsophagusESCC4.48e-091.49e-010.1153
5526PPP2R5BP17T-EHumanEsophagusESCC1.43e-042.36e-010.1278
5526PPP2R5BP19T-EHumanEsophagusESCC2.86e-075.28e-010.1662
5526PPP2R5BP20T-EHumanEsophagusESCC5.13e-071.97e-010.1124
5526PPP2R5BP21T-EHumanEsophagusESCC1.65e-214.50e-010.1617
5526PPP2R5BP22T-EHumanEsophagusESCC5.54e-064.56e-020.1236
5526PPP2R5BP23T-EHumanEsophagusESCC2.22e-062.11e-010.108
5526PPP2R5BP24T-EHumanEsophagusESCC2.58e-071.29e-010.1287
5526PPP2R5BP26T-EHumanEsophagusESCC6.62e-152.46e-010.1276
5526PPP2R5BP27T-EHumanEsophagusESCC7.38e-121.97e-010.1055
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:0043254111EsophagusESCCregulation of protein-containing complex assembly278/8552428/187233.81e-162.77e-14278
GO:0031334111EsophagusESCCpositive regulation of protein-containing complex assembly166/8552237/187232.06e-141.07e-12166
GO:00457865EsophagusESCCnegative regulation of cell cycle236/8552385/187233.62e-109.93e-09236
GO:001631110EsophagusESCCdephosphorylation251/8552417/187231.26e-092.99e-08251
GO:000647018EsophagusESCCprotein dephosphorylation177/8552281/187233.13e-096.72e-08177
GO:00109484EsophagusESCCnegative regulation of cell cycle process177/8552294/187233.26e-074.59e-06177
GO:00510908EsophagusESCCregulation of DNA-binding transcription factor activity252/8552440/187235.22e-076.97e-06252
GO:004677710EsophagusESCCprotein autophosphorylation138/8552227/187232.98e-063.38e-05138
GO:00510918EsophagusESCCpositive regulation of DNA-binding transcription factor activity155/8552260/187233.83e-064.14e-05155
GO:003134616EsophagusESCCpositive regulation of cell projection organization201/8552353/187231.19e-051.11e-04201
GO:001097516EsophagusESCCregulation of neuron projection development240/8552445/187232.48e-041.53e-03240
GO:00182124EsophagusESCCpeptidyl-tyrosine modification202/8552378/187231.34e-036.39e-03202
GO:00181084EsophagusESCCpeptidyl-tyrosine phosphorylation200/8552375/187231.60e-037.45e-03200
GO:00507303EsophagusESCCregulation of peptidyl-tyrosine phosphorylation144/8552264/187232.22e-039.78e-03144
GO:00319521EsophagusESCCregulation of protein autophosphorylation29/855243/187233.25e-031.35e-0229
GO:00109764EsophagusESCCpositive regulation of neuron projection development91/8552163/187235.72e-032.13e-0291
GO:0048011EsophagusESCCneurotrophin TRK receptor signaling pathway17/855224/187231.13e-023.81e-0217
GO:004325420Oral cavityOSCCregulation of protein-containing complex assembly255/7305428/187232.94e-183.15e-16255
GO:003133420Oral cavityOSCCpositive regulation of protein-containing complex assembly153/7305237/187231.18e-158.33e-14153
GO:000647015Oral cavityOSCCprotein dephosphorylation162/7305281/187231.56e-104.56e-09162
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
hsa0411023EsophagusESCCCell cycle126/4205157/84651.34e-155.60e-142.87e-14126
hsa0516510EsophagusESCCHuman papillomavirus infection215/4205331/84657.86e-097.12e-083.65e-08215
hsa0301524EsophagusESCCmRNA surveillance pathway72/420597/84656.12e-074.10e-062.10e-0672
hsa0407116EsophagusESCCSphingolipid signaling pathway85/4205121/84653.04e-061.73e-058.84e-0685
hsa0415210EsophagusESCCAMPK signaling pathway80/4205121/84651.73e-046.67e-043.42e-0480
hsa041517EsophagusESCCPI3K-Akt signaling pathway197/4205354/84651.24e-022.83e-021.45e-02197
hsa041146EsophagusESCCOocyte meiosis77/4205131/84652.19e-024.80e-022.46e-0277
hsa0411033EsophagusESCCCell cycle126/4205157/84651.34e-155.60e-142.87e-14126
hsa0516515EsophagusESCCHuman papillomavirus infection215/4205331/84657.86e-097.12e-083.65e-08215
hsa0301534EsophagusESCCmRNA surveillance pathway72/420597/84656.12e-074.10e-062.10e-0672
hsa0407117EsophagusESCCSphingolipid signaling pathway85/4205121/84653.04e-061.73e-058.84e-0685
hsa0415213EsophagusESCCAMPK signaling pathway80/4205121/84651.73e-046.67e-043.42e-0480
hsa0415114EsophagusESCCPI3K-Akt signaling pathway197/4205354/84651.24e-022.83e-021.45e-02197
hsa0411411EsophagusESCCOocyte meiosis77/4205131/84652.19e-024.80e-022.46e-0277
hsa041108Oral cavityOSCCCell cycle118/3704157/84657.15e-162.66e-141.35e-14118
hsa030158Oral cavityOSCCmRNA surveillance pathway75/370497/84651.30e-112.01e-101.02e-1075
hsa051659Oral cavityOSCCHuman papillomavirus infection200/3704331/84653.83e-104.93e-092.51e-09200
hsa0407114Oral cavityOSCCSphingolipid signaling pathway82/3704121/84656.97e-085.08e-072.58e-0782
hsa041516Oral cavityOSCCPI3K-Akt signaling pathway185/3704354/84656.26e-041.86e-039.49e-04185
hsa041529Oral cavityOSCCAMPK signaling pathway71/3704121/84656.29e-041.86e-039.49e-0471
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
PPP2R5BSNVMissense_Mutationc.457N>Cp.Glu153Glnp.E153QQ15173protein_codingdeleterious(0)probably_damaging(0.986)TCGA-A8-A09X-01Breastbreast invasive carcinomaFemale<65III/IVUnknownUnknownSD
PPP2R5BSNVMissense_Mutationc.652C>Ap.His218Asnp.H218NQ15173protein_codingdeleterious(0)possibly_damaging(0.869)TCGA-AC-A23H-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownPD
PPP2R5BSNVMissense_Mutationrs557535443c.628N>Tp.Arg210Cysp.R210CQ15173protein_codingdeleterious(0)probably_damaging(1)TCGA-AO-A128-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapydoxorubicinSD
PPP2R5BSNVMissense_Mutationc.1007N>Cp.Leu336Prop.L336PQ15173protein_codingdeleterious(0)probably_damaging(1)TCGA-BH-A18V-01Breastbreast invasive carcinomaFemale<65I/IIUnknownUnknownSD
PPP2R5BSNVMissense_Mutationnovelc.979N>Gp.Thr327Alap.T327AQ15173protein_codingdeleterious(0.01)possibly_damaging(0.817)TCGA-E2-A15A-06Breastbreast invasive carcinomaFemale<65III/IVChemotherapycyclophosphamideSD
PPP2R5BdeletionFrame_Shift_Delnovelc.552delCp.Val185TrpfsTer12p.V185Wfs*12Q15173protein_codingTCGA-EW-A2FV-01Breastbreast invasive carcinomaFemale<65III/IVChemotherapydocetaxelSD
PPP2R5BSNVMissense_Mutationnovelc.538N>Cp.Asp180Hisp.D180HQ15173protein_codingdeleterious(0)probably_damaging(0.988)TCGA-C5-A1MP-01Cervixcervical & endocervical cancerFemale<65I/IIUnknownUnknownSD
PPP2R5BSNVMissense_Mutationnovelc.59N>Gp.Ser20Trpp.S20WQ15173protein_codingdeleterious_low_confidence(0)benign(0)TCGA-C5-A8XH-01Cervixcervical & endocervical cancerFemale<65I/IIUnknownUnknownSD
PPP2R5BSNVMissense_Mutationnovelc.334N>Cp.Glu112Glnp.E112QQ15173protein_codingdeleterious(0)possibly_damaging(0.731)TCGA-HM-A4S6-01Cervixcervical & endocervical cancerFemale<65III/IVChemotherapycisplatinCR
PPP2R5BSNVMissense_Mutationnovelc.1014G>Cp.Glu338Aspp.E338DQ15173protein_codingdeleterious(0)probably_damaging(0.987)TCGA-VS-AA62-01Cervixcervical & endocervical cancerFemale<65I/IIChemotherapycisplatinPD
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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