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Gene: PPP2R4 |
Gene summary for PPP2R4 |
Gene summary. |
Gene information | Species | Human | Gene symbol | PPP2R4 | Gene ID | 5524 |
Gene name | protein phosphatase 2 phosphatase activator | |
Gene Alias | PP2A | |
Cytomap | 9q34.11 | |
Gene Type | protein-coding | GO ID | GO:0000226 | UniProtAcc | F6WIT2 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
5524 | PPP2R4 | P1T-E | Human | Esophagus | ESCC | 1.67e-28 | 9.67e-01 | 0.0875 |
5524 | PPP2R4 | P2T-E | Human | Esophagus | ESCC | 1.24e-51 | 7.80e-01 | 0.1177 |
5524 | PPP2R4 | P4T-E | Human | Esophagus | ESCC | 6.67e-35 | 6.29e-01 | 0.1323 |
5524 | PPP2R4 | P5T-E | Human | Esophagus | ESCC | 2.20e-17 | 3.20e-01 | 0.1327 |
5524 | PPP2R4 | P8T-E | Human | Esophagus | ESCC | 2.62e-77 | 1.09e+00 | 0.0889 |
5524 | PPP2R4 | P9T-E | Human | Esophagus | ESCC | 1.45e-25 | 5.06e-01 | 0.1131 |
5524 | PPP2R4 | P10T-E | Human | Esophagus | ESCC | 5.22e-43 | 6.71e-01 | 0.116 |
5524 | PPP2R4 | P11T-E | Human | Esophagus | ESCC | 2.64e-31 | 8.37e-01 | 0.1426 |
5524 | PPP2R4 | P12T-E | Human | Esophagus | ESCC | 5.88e-35 | 5.25e-01 | 0.1122 |
5524 | PPP2R4 | P15T-E | Human | Esophagus | ESCC | 5.31e-38 | 6.78e-01 | 0.1149 |
5524 | PPP2R4 | P16T-E | Human | Esophagus | ESCC | 2.51e-33 | 6.23e-01 | 0.1153 |
5524 | PPP2R4 | P17T-E | Human | Esophagus | ESCC | 6.16e-21 | 7.37e-01 | 0.1278 |
5524 | PPP2R4 | P19T-E | Human | Esophagus | ESCC | 7.97e-13 | 8.78e-01 | 0.1662 |
5524 | PPP2R4 | P20T-E | Human | Esophagus | ESCC | 3.17e-29 | 5.38e-01 | 0.1124 |
5524 | PPP2R4 | P21T-E | Human | Esophagus | ESCC | 6.54e-59 | 9.51e-01 | 0.1617 |
5524 | PPP2R4 | P22T-E | Human | Esophagus | ESCC | 1.90e-43 | 6.52e-01 | 0.1236 |
5524 | PPP2R4 | P23T-E | Human | Esophagus | ESCC | 9.45e-47 | 9.24e-01 | 0.108 |
5524 | PPP2R4 | P24T-E | Human | Esophagus | ESCC | 4.71e-53 | 9.03e-01 | 0.1287 |
5524 | PPP2R4 | P26T-E | Human | Esophagus | ESCC | 1.61e-32 | 5.18e-01 | 0.1276 |
5524 | PPP2R4 | P27T-E | Human | Esophagus | ESCC | 5.57e-40 | 6.19e-01 | 0.1055 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa05415 | Colorectum | AD | Diabetic cardiomyopathy | 114/2092 | 203/8465 | 3.65e-22 | 3.06e-20 | 1.95e-20 | 114 |
hsa054151 | Colorectum | AD | Diabetic cardiomyopathy | 114/2092 | 203/8465 | 3.65e-22 | 3.06e-20 | 1.95e-20 | 114 |
hsa054152 | Colorectum | SER | Diabetic cardiomyopathy | 103/1580 | 203/8465 | 1.45e-25 | 1.61e-23 | 1.17e-23 | 103 |
hsa054153 | Colorectum | SER | Diabetic cardiomyopathy | 103/1580 | 203/8465 | 1.45e-25 | 1.61e-23 | 1.17e-23 | 103 |
hsa054154 | Colorectum | MSS | Diabetic cardiomyopathy | 106/1875 | 203/8465 | 2.47e-21 | 1.62e-19 | 9.92e-20 | 106 |
hsa04931 | Colorectum | MSS | Insulin resistance | 36/1875 | 108/8465 | 4.74e-03 | 2.01e-02 | 1.23e-02 | 36 |
hsa054155 | Colorectum | MSS | Diabetic cardiomyopathy | 106/1875 | 203/8465 | 2.47e-21 | 1.62e-19 | 9.92e-20 | 106 |
hsa049311 | Colorectum | MSS | Insulin resistance | 36/1875 | 108/8465 | 4.74e-03 | 2.01e-02 | 1.23e-02 | 36 |
hsa054156 | Colorectum | MSI-H | Diabetic cardiomyopathy | 57/797 | 203/8465 | 1.15e-14 | 3.11e-13 | 2.61e-13 | 57 |
hsa054157 | Colorectum | MSI-H | Diabetic cardiomyopathy | 57/797 | 203/8465 | 1.15e-14 | 3.11e-13 | 2.61e-13 | 57 |
hsa0541525 | Endometrium | AEH | Diabetic cardiomyopathy | 86/1197 | 203/8465 | 2.62e-23 | 1.22e-21 | 8.90e-22 | 86 |
hsa05415111 | Endometrium | AEH | Diabetic cardiomyopathy | 86/1197 | 203/8465 | 2.62e-23 | 1.22e-21 | 8.90e-22 | 86 |
hsa0541526 | Endometrium | EEC | Diabetic cardiomyopathy | 86/1237 | 203/8465 | 2.59e-22 | 9.46e-21 | 7.05e-21 | 86 |
hsa0541535 | Endometrium | EEC | Diabetic cardiomyopathy | 86/1237 | 203/8465 | 2.59e-22 | 9.46e-21 | 7.05e-21 | 86 |
hsa0541522 | Liver | HCC | Diabetic cardiomyopathy | 151/4020 | 203/8465 | 2.72e-15 | 1.01e-13 | 5.63e-14 | 151 |
hsa0541532 | Liver | HCC | Diabetic cardiomyopathy | 151/4020 | 203/8465 | 2.72e-15 | 1.01e-13 | 5.63e-14 | 151 |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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