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Gene: PPP1R7 |
Gene summary for PPP1R7 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | PPP1R7 | Gene ID | 5510 |
| Gene name | protein phosphatase 1 regulatory subunit 7 | |
| Gene Alias | SDS22 | |
| Cytomap | 2q37.3 | |
| Gene Type | protein-coding | GO ID | GO:0006464 | UniProtAcc | Q15435 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 5510 | PPP1R7 | HTA11_2487_2000001011 | Human | Colorectum | SER | 5.66e-03 | 3.33e-01 | -0.1808 |
| 5510 | PPP1R7 | HTA11_1938_2000001011 | Human | Colorectum | AD | 2.02e-04 | 4.28e-01 | -0.0811 |
| 5510 | PPP1R7 | HTA11_347_2000001011 | Human | Colorectum | AD | 5.04e-11 | 4.07e-01 | -0.1954 |
| 5510 | PPP1R7 | HTA11_3361_2000001011 | Human | Colorectum | AD | 4.32e-02 | 3.12e-01 | -0.1207 |
| 5510 | PPP1R7 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.81e-06 | 3.92e-01 | -0.1464 |
| 5510 | PPP1R7 | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.12e-07 | 4.39e-01 | -0.059 |
| 5510 | PPP1R7 | HTA11_546_2000001011 | Human | Colorectum | AD | 6.55e-04 | 4.47e-01 | -0.0842 |
| 5510 | PPP1R7 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 9.69e-03 | 2.84e-01 | 0.281 |
| 5510 | PPP1R7 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 9.12e-03 | 2.92e-01 | 0.3859 |
| 5510 | PPP1R7 | A015-C-203 | Human | Colorectum | FAP | 6.94e-03 | -1.08e-01 | -0.1294 |
| 5510 | PPP1R7 | A002-C-116 | Human | Colorectum | FAP | 1.73e-03 | -8.85e-02 | -0.0452 |
| 5510 | PPP1R7 | A018-E-020 | Human | Colorectum | FAP | 2.03e-02 | -1.44e-01 | -0.2034 |
| 5510 | PPP1R7 | LZE4T | Human | Esophagus | ESCC | 1.81e-17 | 4.76e-01 | 0.0811 |
| 5510 | PPP1R7 | LZE7T | Human | Esophagus | ESCC | 5.04e-10 | 4.38e-01 | 0.0667 |
| 5510 | PPP1R7 | LZE8T | Human | Esophagus | ESCC | 4.07e-16 | 2.99e-01 | 0.067 |
| 5510 | PPP1R7 | LZE20T | Human | Esophagus | ESCC | 4.67e-12 | 2.65e-01 | 0.0662 |
| 5510 | PPP1R7 | LZE22T | Human | Esophagus | ESCC | 2.81e-10 | 4.31e-01 | 0.068 |
| 5510 | PPP1R7 | LZE24D1 | Human | Esophagus | HGIN | 3.51e-02 | 3.32e-01 | 0.054 |
| 5510 | PPP1R7 | LZE24T | Human | Esophagus | ESCC | 4.53e-22 | 7.01e-01 | 0.0596 |
| 5510 | PPP1R7 | LZE21T | Human | Esophagus | ESCC | 4.05e-08 | 2.75e-01 | 0.0655 |
| Page: 1 2 3 4 5 6 7 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Colorectum (GSE201348) |  | FAP: Familial adenomatous polyposis |
| CRC: Colorectal cancer | ||
| Colorectum (HTA11) |  | AD: Adenomas |
| SER: Sessile serrated lesions | ||
| MSI-H: Microsatellite-high colorectal cancer | ||
| MSS: Microsatellite stable colorectal cancer | ||
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma | ||
| Prostate |  | BPH: Benign Prostatic Hyperplasia |
| Skin |  | AK: Actinic keratosis |
| cSCC: Cutaneous squamous cell carcinoma | ||
| SCCIS:squamous cell carcinoma in situ | ||
| Thyroid |  | ATC: Anaplastic thyroid cancer |
| HT: Hashimoto's thyroiditis | ||
| PTC: Papillary thyroid cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:0016311 | Colorectum | AD | dephosphorylation | 123/3918 | 417/18723 | 1.84e-05 | 3.82e-04 | 123 |
| GO:0006470 | Colorectum | AD | protein dephosphorylation | 88/3918 | 281/18723 | 2.56e-05 | 4.89e-04 | 88 |
| GO:0035303 | Colorectum | AD | regulation of dephosphorylation | 46/3918 | 128/18723 | 6.20e-05 | 1.04e-03 | 46 |
| GO:0035304 | Colorectum | AD | regulation of protein dephosphorylation | 33/3918 | 90/18723 | 4.23e-04 | 4.77e-03 | 33 |
| GO:0035306 | Colorectum | AD | positive regulation of dephosphorylation | 22/3918 | 59/18723 | 2.86e-03 | 2.14e-02 | 22 |
| GO:00064701 | Colorectum | SER | protein dephosphorylation | 65/2897 | 281/18723 | 4.44e-04 | 6.51e-03 | 65 |
| GO:00353031 | Colorectum | SER | regulation of dephosphorylation | 33/2897 | 128/18723 | 1.71e-03 | 1.78e-02 | 33 |
| GO:00353041 | Colorectum | SER | regulation of protein dephosphorylation | 25/2897 | 90/18723 | 2.00e-03 | 1.98e-02 | 25 |
| GO:00163111 | Colorectum | SER | dephosphorylation | 86/2897 | 417/18723 | 2.73e-03 | 2.46e-02 | 86 |
| GO:00353032 | Colorectum | MSS | regulation of dephosphorylation | 41/3467 | 128/18723 | 1.64e-04 | 2.33e-03 | 41 |
| GO:00353042 | Colorectum | MSS | regulation of protein dephosphorylation | 30/3467 | 90/18723 | 5.58e-04 | 6.19e-03 | 30 |
| GO:00064702 | Colorectum | MSS | protein dephosphorylation | 73/3467 | 281/18723 | 1.15e-03 | 1.12e-02 | 73 |
| GO:00163112 | Colorectum | MSS | dephosphorylation | 101/3467 | 417/18723 | 1.98e-03 | 1.70e-02 | 101 |
| GO:00163113 | Colorectum | FAP | dephosphorylation | 95/2622 | 417/18723 | 7.07e-07 | 3.32e-05 | 95 |
| GO:00064704 | Colorectum | FAP | protein dephosphorylation | 69/2622 | 281/18723 | 1.47e-06 | 6.39e-05 | 69 |
| GO:00353034 | Colorectum | FAP | regulation of dephosphorylation | 36/2622 | 128/18723 | 2.22e-05 | 5.28e-04 | 36 |
| GO:00353044 | Colorectum | FAP | regulation of protein dephosphorylation | 24/2622 | 90/18723 | 1.12e-03 | 1.08e-02 | 24 |
| GO:00353061 | Colorectum | FAP | positive regulation of dephosphorylation | 16/2622 | 59/18723 | 5.95e-03 | 3.75e-02 | 16 |
| GO:001631110 | Esophagus | ESCC | dephosphorylation | 251/8552 | 417/18723 | 1.26e-09 | 2.99e-08 | 251 |
| GO:000647018 | Esophagus | ESCC | protein dephosphorylation | 177/8552 | 281/18723 | 3.13e-09 | 6.72e-08 | 177 |
| Page: 1 2 3 4 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| PPP1R7 | SNV | Missense_Mutation | c.370N>A | p.Glu124Lys | p.E124K | Q15435 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-A7-A13G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | PD | |
| PPP1R7 | SNV | Missense_Mutation | novel | c.121N>A | p.Ala41Thr | p.A41T | Q15435 | protein_coding | tolerated(0.35) | benign(0) | TCGA-PL-A8LV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
| PPP1R7 | insertion | In_Frame_Ins | novel | c.844_845insTTTCTA | p.Ala282delinsValSerThr | p.A282delinsVST | Q15435 | protein_coding | TCGA-A2-A0CQ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | ||
| PPP1R7 | insertion | Frame_Shift_Ins | novel | c.846_847insATTGTCAGCCTTTCTTCAGAGCG | p.Ser283IlefsTer21 | p.S283Ifs*21 | Q15435 | protein_coding | TCGA-A2-A0CQ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | ||
| PPP1R7 | insertion | In_Frame_Ins | novel | c.805_806insCTCACTGCAAGCTCC | p.Gly269delinsAlaHisCysLysLeuArg | p.G269delinsAHCKLR | Q15435 | protein_coding | TCGA-BH-A0B8-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | arimidex | SD | ||
| PPP1R7 | SNV | Missense_Mutation | c.91N>A | p.Glu31Lys | p.E31K | Q15435 | protein_coding | tolerated(0.05) | benign(0.114) | TCGA-EA-A3HQ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
| PPP1R7 | SNV | Missense_Mutation | c.889G>A | p.Glu297Lys | p.E297K | Q15435 | protein_coding | tolerated(0.36) | benign(0.007) | TCGA-ZJ-AAXT-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unknown | Unknown | SD | |
| PPP1R7 | SNV | Missense_Mutation | c.280N>G | p.Phe94Val | p.F94V | Q15435 | protein_coding | deleterious(0.02) | benign(0.206) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
| PPP1R7 | SNV | Missense_Mutation | rs758294774 | c.988N>T | p.Arg330Trp | p.R330W | Q15435 | protein_coding | tolerated(0.05) | benign(0.386) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
| PPP1R7 | SNV | Missense_Mutation | rs777048169 | c.67G>A | p.Glu23Lys | p.E23K | Q15435 | protein_coding | deleterious(0.01) | benign(0.115) | TCGA-D5-6931-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
| Page: 1 2 3 4 5 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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