![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: PPP1R37 |
Gene summary for PPP1R37 |
![]() |
Gene information | Species | Human | Gene symbol | PPP1R37 | Gene ID | 284352 |
Gene name | protein phosphatase 1 regulatory subunit 37 | |
Gene Alias | LRRC68 | |
Cytomap | 19q13.32 | |
Gene Type | protein-coding | GO ID | GO:0008150 | UniProtAcc | O75864 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
284352 | PPP1R37 | LZE22T | Human | Esophagus | ESCC | 2.83e-02 | 1.82e-01 | 0.068 |
284352 | PPP1R37 | LZE24T | Human | Esophagus | ESCC | 6.21e-14 | 3.98e-01 | 0.0596 |
284352 | PPP1R37 | P1T-E | Human | Esophagus | ESCC | 9.33e-07 | 3.42e-01 | 0.0875 |
284352 | PPP1R37 | P2T-E | Human | Esophagus | ESCC | 7.61e-26 | 2.90e-01 | 0.1177 |
284352 | PPP1R37 | P4T-E | Human | Esophagus | ESCC | 1.32e-09 | 2.27e-01 | 0.1323 |
284352 | PPP1R37 | P5T-E | Human | Esophagus | ESCC | 2.20e-15 | 2.56e-01 | 0.1327 |
284352 | PPP1R37 | P8T-E | Human | Esophagus | ESCC | 1.18e-41 | 7.50e-01 | 0.0889 |
284352 | PPP1R37 | P9T-E | Human | Esophagus | ESCC | 1.23e-03 | 1.81e-01 | 0.1131 |
284352 | PPP1R37 | P10T-E | Human | Esophagus | ESCC | 1.96e-43 | 7.23e-01 | 0.116 |
284352 | PPP1R37 | P11T-E | Human | Esophagus | ESCC | 2.45e-14 | 4.98e-01 | 0.1426 |
284352 | PPP1R37 | P12T-E | Human | Esophagus | ESCC | 3.26e-20 | 3.67e-01 | 0.1122 |
284352 | PPP1R37 | P15T-E | Human | Esophagus | ESCC | 8.23e-21 | 3.84e-01 | 0.1149 |
284352 | PPP1R37 | P16T-E | Human | Esophagus | ESCC | 4.30e-10 | 1.60e-01 | 0.1153 |
284352 | PPP1R37 | P17T-E | Human | Esophagus | ESCC | 1.61e-08 | 2.59e-01 | 0.1278 |
284352 | PPP1R37 | P20T-E | Human | Esophagus | ESCC | 1.65e-21 | 4.08e-01 | 0.1124 |
284352 | PPP1R37 | P21T-E | Human | Esophagus | ESCC | 2.11e-08 | 1.45e-01 | 0.1617 |
284352 | PPP1R37 | P22T-E | Human | Esophagus | ESCC | 2.72e-20 | 3.24e-01 | 0.1236 |
284352 | PPP1R37 | P23T-E | Human | Esophagus | ESCC | 2.27e-18 | 4.51e-01 | 0.108 |
284352 | PPP1R37 | P24T-E | Human | Esophagus | ESCC | 2.57e-10 | 2.36e-01 | 0.1287 |
284352 | PPP1R37 | P26T-E | Human | Esophagus | ESCC | 2.41e-23 | 3.98e-01 | 0.1276 |
Page: 1 2 3 4 5 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PPP1R37 | SNV | Missense_Mutation | novel | c.1718N>A | p.Arg573Gln | p.R573Q | O75864 | protein_coding | deleterious(0) | probably_damaging(0.965) | TCGA-E9-A5UO-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PPP1R37 | SNV | Missense_Mutation | c.1159N>A | p.Glu387Lys | p.E387K | O75864 | protein_coding | deleterious(0.03) | benign(0.047) | TCGA-IR-A3LK-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | cisplatin | PD | |
PPP1R37 | SNV | Missense_Mutation | novel | c.1400N>T | p.Pro467Leu | p.P467L | O75864 | protein_coding | deleterious(0.04) | benign(0.026) | TCGA-VS-A9U6-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD |
PPP1R37 | SNV | Missense_Mutation | novel | c.1000N>G | p.Ser334Gly | p.S334G | O75864 | protein_coding | tolerated(0.07) | benign(0.011) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PPP1R37 | SNV | Missense_Mutation | novel | c.1643G>A | p.Ser548Asn | p.S548N | O75864 | protein_coding | tolerated_low_confidence(0.2) | benign(0.102) | TCGA-DF-A2KN-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
PPP1R37 | SNV | Missense_Mutation | novel | c.328N>A | p.Asp110Asn | p.D110N | O75864 | protein_coding | tolerated(0.05) | benign(0.011) | TCGA-DF-A2KU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
PPP1R37 | SNV | Missense_Mutation | novel | c.1295N>T | p.Ala432Val | p.A432V | O75864 | protein_coding | tolerated(0.13) | benign(0.043) | TCGA-DF-A2KU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
PPP1R37 | SNV | Missense_Mutation | novel | c.455C>T | p.Ser152Leu | p.S152L | O75864 | protein_coding | tolerated(0.07) | benign(0.173) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PPP1R37 | SNV | Missense_Mutation | rs757346574 | c.569C>T | p.Thr190Met | p.T190M | O75864 | protein_coding | deleterious(0) | benign(0.301) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PPP1R37 | SNV | Missense_Mutation | novel | c.1435G>A | p.Ala479Thr | p.A479T | O75864 | protein_coding | tolerated(0.61) | benign(0.043) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
Page: 1 2 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |