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Gene: PPP1R14B |
Gene summary for PPP1R14B |
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Gene information | Species | Human | Gene symbol | PPP1R14B | Gene ID | 26472 |
Gene name | protein phosphatase 1 regulatory inhibitor subunit 14B | |
Gene Alias | PHI-1 | |
Cytomap | 11q13.1 | |
Gene Type | protein-coding | GO ID | GO:0002376 | UniProtAcc | Q96C90 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
26472 | PPP1R14B | GSM4909282 | Human | Breast | IDC | 1.81e-06 | 4.02e-01 | -0.0288 |
26472 | PPP1R14B | GSM4909286 | Human | Breast | IDC | 2.13e-06 | 1.60e-01 | 0.1081 |
26472 | PPP1R14B | GSM4909288 | Human | Breast | IDC | 2.66e-05 | 2.00e-01 | 0.0988 |
26472 | PPP1R14B | GSM4909293 | Human | Breast | IDC | 4.44e-19 | 5.34e-01 | 0.1581 |
26472 | PPP1R14B | GSM4909294 | Human | Breast | IDC | 8.73e-14 | 3.38e-01 | 0.2022 |
26472 | PPP1R14B | GSM4909295 | Human | Breast | IDC | 3.29e-02 | 2.34e-01 | 0.0898 |
26472 | PPP1R14B | GSM4909296 | Human | Breast | IDC | 2.65e-08 | 1.31e-01 | 0.1524 |
26472 | PPP1R14B | GSM4909297 | Human | Breast | IDC | 1.46e-13 | -3.38e-01 | 0.1517 |
26472 | PPP1R14B | GSM4909299 | Human | Breast | IDC | 1.22e-03 | -3.41e-01 | 0.035 |
26472 | PPP1R14B | GSM4909304 | Human | Breast | IDC | 1.64e-06 | 3.81e-01 | 0.1636 |
26472 | PPP1R14B | GSM4909311 | Human | Breast | IDC | 8.83e-33 | -3.10e-01 | 0.1534 |
26472 | PPP1R14B | GSM4909312 | Human | Breast | IDC | 7.24e-17 | -4.01e-01 | 0.1552 |
26472 | PPP1R14B | GSM4909315 | Human | Breast | IDC | 1.10e-09 | 4.08e-01 | 0.21 |
26472 | PPP1R14B | GSM4909316 | Human | Breast | IDC | 3.05e-14 | 5.33e-01 | 0.21 |
26472 | PPP1R14B | GSM4909318 | Human | Breast | IDC | 1.59e-08 | 4.34e-01 | 0.2031 |
26472 | PPP1R14B | GSM4909319 | Human | Breast | IDC | 1.82e-30 | -4.01e-01 | 0.1563 |
26472 | PPP1R14B | GSM4909320 | Human | Breast | IDC | 3.42e-04 | -4.45e-03 | 0.1575 |
26472 | PPP1R14B | GSM4909321 | Human | Breast | IDC | 4.05e-17 | 2.62e-01 | 0.1559 |
26472 | PPP1R14B | brca1 | Human | Breast | Precancer | 1.22e-22 | 5.84e-01 | -0.0338 |
26472 | PPP1R14B | brca2 | Human | Breast | Precancer | 2.91e-03 | 1.37e-01 | -0.024 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PPP1R14B | SNV | Missense_Mutation | novel | c.435N>C | p.Gln145His | p.Q145H | Q96C90 | protein_coding | deleterious(0.01) | possibly_damaging(0.864) | TCGA-AR-A2LE-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | PD |
PPP1R14B | SNV | Missense_Mutation | c.262N>A | p.Glu88Lys | p.E88K | Q96C90 | protein_coding | deleterious(0.02) | possibly_damaging(0.538) | TCGA-BH-A0HP-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | doxorubicin | SD | |
PPP1R14B | SNV | Missense_Mutation | novel | c.148N>C | p.Val50Leu | p.V50L | Q96C90 | protein_coding | tolerated(0.7) | benign(0.189) | TCGA-MX-A5UJ-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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