Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

Home

Download

Statistics

Help

Contact
Center for Computational Systems Medicine
leaf

Gene summary

leaf

Malignant transformation analysis

leaf

Malignant transformation related pathway analysis

leaf

Cell-cell communication analysis

leaf

Single-cell gene regulatory network inference analysis

leaf

Somatic mutation of malignant transformation related genes

leaf

Related drugs of malignant transformation related genes

Gene: PPM1E

Gene summary for PPM1E

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

PPM1E

Gene ID

22843

Gene nameprotein phosphatase, Mg2+/Mn2+ dependent 1E
Gene AliasCAMKPN
Cytomap17q22
Gene Typeprotein-coding
GO ID

GO:0001932

UniProtAcc

A7E2X1


Top

Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
22843PPM1EAEH-subject4HumanEndometriumAEH4.55e-052.04e-01-0.2657
Page: 1 

check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
EndometriumThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AEH: Atypical endometrial hyperplasia
EEC: Endometrioid Cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

Top

Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
Page: 1 2 3 4 5 6 7 8 9 

check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:000701516EndometriumAEHactin filament organization98/2100442/187231.99e-112.98e-0998
GO:003297016EndometriumAEHregulation of actin filament-based process89/2100397/187239.14e-111.10e-0889
GO:190290316EndometriumAEHregulation of supramolecular fiber organization83/2100383/187232.20e-091.78e-0783
GO:003295616EndometriumAEHregulation of actin cytoskeleton organization77/2100358/187231.18e-087.76e-0777
GO:011005316EndometriumAEHregulation of actin filament organization61/2100278/187231.83e-078.11e-0661
GO:003103210EndometriumAEHactomyosin structure organization46/2100196/187238.00e-072.91e-0546
GO:190290516EndometriumAEHpositive regulation of supramolecular fiber organization48/2100209/187239.11e-073.20e-0548
GO:005101716EndometriumAEHactin filament bundle assembly39/2100157/187231.21e-063.91e-0539
GO:006157216EndometriumAEHactin filament bundle organization39/2100161/187232.36e-066.86e-0539
GO:003223115EndometriumAEHregulation of actin filament bundle assembly28/2100105/187238.87e-062.09e-0428
GO:003003815EndometriumAEHcontractile actin filament bundle assembly28/2100106/187231.08e-052.45e-0428
GO:004314915EndometriumAEHstress fiber assembly28/2100106/187231.08e-052.45e-0428
GO:005149514EndometriumAEHpositive regulation of cytoskeleton organization47/2100226/187232.00e-054.05e-0447
GO:005149216EndometriumAEHregulation of stress fiber assembly24/210091/187234.61e-057.68e-0424
GO:004593616EndometriumAEHnegative regulation of phosphate metabolic process77/2100441/187235.13e-058.25e-0477
GO:001056316EndometriumAEHnegative regulation of phosphorus metabolic process77/2100442/187235.54e-058.79e-0477
GO:011002016EndometriumAEHregulation of actomyosin structure organization25/2100100/187238.41e-051.25e-0325
GO:005134816EndometriumAEHnegative regulation of transferase activity51/2100268/187231.06e-041.52e-0351
GO:003223310EndometriumAEHpositive regulation of actin filament bundle assembly18/210063/187231.32e-041.80e-0318
GO:000193315EndometriumAEHnegative regulation of protein phosphorylation60/2100342/187232.89e-043.31e-0360
Page: 1 2 

check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
Page: 1 

Top

Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
Page: 1 

Top

Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
Page: 1 

Top

Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
PPM1ESNVMissense_Mutationc.1053G>Tp.Gln351Hisp.Q351HQ8WY54protein_codingdeleterious(0)probably_damaging(0.999)TCGA-A1-A0SO-01Breastbreast invasive carcinomaFemale>=65I/IIChemotherapySD
PPM1ESNVMissense_Mutationc.1633N>Tp.Arg545Cysp.R545CQ8WY54protein_codingdeleterious_low_confidence(0)probably_damaging(0.998)TCGA-A2-A0T3-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapyadriamycinSD
PPM1ESNVMissense_Mutationc.185N>Tp.Ser62Leup.S62LQ8WY54protein_codingtolerated_low_confidence(0.4)benign(0)TCGA-AC-A23H-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownPD
PPM1ESNVMissense_Mutationc.1105N>Gp.Pro369Alap.P369AQ8WY54protein_codingdeleterious(0.01)probably_damaging(0.997)TCGA-AO-A03P-01Breastbreast invasive carcinomaFemale<65I/IIHormone TherapyletrozolePD
PPM1ESNVMissense_Mutationnovelc.1730N>Tp.Ala577Valp.A577VQ8WY54protein_codingdeleterious_low_confidence(0.04)benign(0.079)TCGA-E2-A155-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapycytoxanSD
PPM1ESNVMissense_Mutationc.1412N>Tp.Ser471Leup.S471LQ8WY54protein_codingtolerated(0.08)benign(0.159)TCGA-GM-A2D9-01Breastbreast invasive carcinomaFemale>=65I/IIHormone TherapyarimidexSD
PPM1EinsertionNonsense_Mutationnovelc.2262_2263insAATTTGAGGTAGGAGAACAGGAACCCCAGGCAGGGp.Glu755AsnfsTer4p.E755Nfs*4Q8WY54protein_codingTCGA-A8-A093-01Breastbreast invasive carcinomaFemale<65I/IIHormone TherapytamoxiphenSD
PPM1EinsertionFrame_Shift_Insnovelc.1860_1861insCCTTGGGTCAGCCACATAACTCCTCCTGGCTTAAGGGAGTTp.Ser621ProfsTer94p.S621Pfs*94Q8WY54protein_codingTCGA-A8-A09E-01Breastbreast invasive carcinomaFemale>=65III/IVHormone TherapyanastrozoleSD
PPM1EinsertionFrame_Shift_Insnovelc.653_654insTCGCTTGAACCAGAGAGGCAGAGGTTGCp.Lys218AsnfsTer23p.K218Nfs*23Q8WY54protein_codingTCGA-AO-A0JB-01Breastbreast invasive carcinomaFemale<65III/IVChemotherapycyclophosphamideSD
PPM1EinsertionIn_Frame_Insnovelc.809_810insTTCAAAATTGCTGTTACAp.Ala270_Val271insSerLysLeuLeuLeuGlnp.A270_V271insSKLLLQQ8WY54protein_codingTCGA-AR-A0U0-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
Page: 1 2 3 4 5 6 7 8 9 

Top

Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
Page: 1