![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: PPFIBP2 |
Gene summary for PPFIBP2 |
![]() |
Gene information | Species | Human | Gene symbol | PPFIBP2 | Gene ID | 8495 |
Gene name | PPFIA binding protein 2 | |
Gene Alias | Cclp1 | |
Cytomap | 11p15.4 | |
Gene Type | protein-coding | GO ID | GO:0007528 | UniProtAcc | Q8ND30 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
8495 | PPFIBP2 | LZE4T | Human | Esophagus | ESCC | 2.74e-05 | 1.21e-01 | 0.0811 |
8495 | PPFIBP2 | LZE7T | Human | Esophagus | ESCC | 8.96e-03 | 2.32e-01 | 0.0667 |
8495 | PPFIBP2 | LZE8T | Human | Esophagus | ESCC | 8.97e-04 | 1.27e-01 | 0.067 |
8495 | PPFIBP2 | LZE24T | Human | Esophagus | ESCC | 2.69e-19 | 4.10e-01 | 0.0596 |
8495 | PPFIBP2 | LZE21T | Human | Esophagus | ESCC | 4.98e-02 | 1.55e-01 | 0.0655 |
8495 | PPFIBP2 | P1T-E | Human | Esophagus | ESCC | 6.69e-05 | 1.52e-01 | 0.0875 |
8495 | PPFIBP2 | P2T-E | Human | Esophagus | ESCC | 1.25e-18 | 2.81e-01 | 0.1177 |
8495 | PPFIBP2 | P4T-E | Human | Esophagus | ESCC | 7.39e-11 | 1.77e-01 | 0.1323 |
8495 | PPFIBP2 | P8T-E | Human | Esophagus | ESCC | 5.92e-12 | 1.95e-01 | 0.0889 |
8495 | PPFIBP2 | P9T-E | Human | Esophagus | ESCC | 3.21e-09 | 9.08e-02 | 0.1131 |
8495 | PPFIBP2 | P10T-E | Human | Esophagus | ESCC | 2.72e-14 | 3.56e-01 | 0.116 |
8495 | PPFIBP2 | P11T-E | Human | Esophagus | ESCC | 9.09e-06 | 2.57e-01 | 0.1426 |
8495 | PPFIBP2 | P12T-E | Human | Esophagus | ESCC | 6.61e-31 | 6.06e-01 | 0.1122 |
8495 | PPFIBP2 | P15T-E | Human | Esophagus | ESCC | 4.15e-13 | 2.38e-01 | 0.1149 |
8495 | PPFIBP2 | P16T-E | Human | Esophagus | ESCC | 1.52e-16 | 2.02e-01 | 0.1153 |
8495 | PPFIBP2 | P17T-E | Human | Esophagus | ESCC | 2.12e-03 | 1.06e-01 | 0.1278 |
8495 | PPFIBP2 | P20T-E | Human | Esophagus | ESCC | 2.43e-08 | 7.58e-02 | 0.1124 |
8495 | PPFIBP2 | P21T-E | Human | Esophagus | ESCC | 1.65e-11 | 3.13e-02 | 0.1617 |
8495 | PPFIBP2 | P22T-E | Human | Esophagus | ESCC | 4.35e-16 | 7.63e-02 | 0.1236 |
8495 | PPFIBP2 | P23T-E | Human | Esophagus | ESCC | 3.47e-08 | 1.77e-01 | 0.108 |
Page: 1 2 3 4 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00508087 | Prostate | BPH | synapse organization | 103/3107 | 426/18723 | 3.19e-05 | 3.61e-04 | 103 |
GO:005080813 | Prostate | Tumor | synapse organization | 105/3246 | 426/18723 | 7.20e-05 | 7.62e-04 | 105 |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PPFIBP2 | SNV | Missense_Mutation | rs776033358 | c.2138C>T | p.Ser713Leu | p.S713L | Q8ND30 | protein_coding | deleterious(0.02) | probably_damaging(0.941) | TCGA-A1-A0SF-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | tc | SD |
PPFIBP2 | SNV | Missense_Mutation | novel | c.751N>T | p.Asp251Tyr | p.D251Y | Q8ND30 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PPFIBP2 | SNV | Missense_Mutation | rs772240559 | c.2495N>T | p.Ser832Leu | p.S832L | Q8ND30 | protein_coding | deleterious(0.01) | possibly_damaging(0.77) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PPFIBP2 | SNV | Missense_Mutation | rs140620299 | c.733G>A | p.Glu245Lys | p.E245K | Q8ND30 | protein_coding | tolerated(0.07) | possibly_damaging(0.577) | TCGA-BH-A18F-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | CR |
PPFIBP2 | SNV | Missense_Mutation | rs754353873 | c.1241N>A | p.Ser414Asn | p.S414N | Q8ND30 | protein_coding | tolerated(0.45) | benign(0.001) | TCGA-BH-A18G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PPFIBP2 | SNV | Missense_Mutation | novel | c.94G>T | p.Gly32Cys | p.G32C | Q8ND30 | protein_coding | deleterious(0.01) | benign(0.029) | TCGA-LL-A7SZ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | CR |
PPFIBP2 | insertion | Frame_Shift_Ins | novel | c.2246_2247insCACCTCACTGAGCTTTCTTGGGTTTTCTAAA | p.Ile750ThrfsTer51 | p.I750Tfs*51 | Q8ND30 | protein_coding | TCGA-A2-A04Y-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD | ||
PPFIBP2 | insertion | In_Frame_Ins | novel | c.135_136insCTT | p.Met45_Asn46insLeu | p.M45_N46insL | Q8ND30 | protein_coding | TCGA-AO-A0JB-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cyclophosphamide | SD | ||
PPFIBP2 | insertion | Nonsense_Mutation | novel | c.136_137insGTTCCTTGATGTCTGCTGACAGGTAGCCATATTTCCTC | p.Asn46SerfsTer9 | p.N46Sfs*9 | Q8ND30 | protein_coding | TCGA-AO-A0JB-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cyclophosphamide | SD | ||
PPFIBP2 | SNV | Missense_Mutation | novel | c.799N>T | p.Leu267Phe | p.L267F | Q8ND30 | protein_coding | tolerated(0.7) | benign(0.434) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
Page: 1 2 3 4 5 6 7 8 9 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |