|
|||||
|
 | |
| |
| |
| |
| |
| |
|
Gene: PPDPF |
Gene summary for PPDPF |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | PPDPF | Gene ID | 79144 |
| Gene name | pancreatic progenitor cell differentiation and proliferation factor | |
| Gene Alias | C20orf149 | |
| Cytomap | 20q13.33 | |
| Gene Type | protein-coding | GO ID | GO:0008150 | UniProtAcc | Q9H3Y8 |
Top |
Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 79144 | PPDPF | GSM4909277 | Human | Breast | Precancer | 3.82e-02 | -7.28e-01 | 0.0177 |
| 79144 | PPDPF | GSM4909280 | Human | Breast | Precancer | 2.62e-02 | -5.01e-01 | 0.0305 |
| 79144 | PPDPF | GSM4909285 | Human | Breast | IDC | 1.57e-33 | -4.25e-01 | 0.21 |
| 79144 | PPDPF | GSM4909286 | Human | Breast | IDC | 1.83e-03 | 1.87e-01 | 0.1081 |
| 79144 | PPDPF | GSM4909288 | Human | Breast | IDC | 7.45e-08 | -6.67e-01 | 0.0988 |
| 79144 | PPDPF | GSM4909291 | Human | Breast | IDC | 7.48e-49 | 6.19e-01 | 0.1753 |
| 79144 | PPDPF | GSM4909294 | Human | Breast | IDC | 5.62e-07 | 9.96e-02 | 0.2022 |
| 79144 | PPDPF | GSM4909295 | Human | Breast | IDC | 1.50e-05 | 2.75e-01 | 0.0898 |
| 79144 | PPDPF | GSM4909296 | Human | Breast | IDC | 3.81e-09 | 7.14e-02 | 0.1524 |
| 79144 | PPDPF | GSM4909297 | Human | Breast | IDC | 1.14e-37 | 3.09e-01 | 0.1517 |
| 79144 | PPDPF | GSM4909298 | Human | Breast | IDC | 5.54e-51 | 5.04e-01 | 0.1551 |
| 79144 | PPDPF | GSM4909301 | Human | Breast | IDC | 1.12e-19 | 3.48e-01 | 0.1577 |
| 79144 | PPDPF | GSM4909302 | Human | Breast | IDC | 5.01e-15 | 2.11e-01 | 0.1545 |
| 79144 | PPDPF | GSM4909304 | Human | Breast | IDC | 4.96e-74 | 5.61e-01 | 0.1636 |
| 79144 | PPDPF | GSM4909306 | Human | Breast | IDC | 1.24e-02 | 2.19e-01 | 0.1564 |
| 79144 | PPDPF | GSM4909309 | Human | Breast | IDC | 1.70e-10 | 1.39e-01 | 0.0483 |
| 79144 | PPDPF | GSM4909311 | Human | Breast | IDC | 5.29e-58 | 2.79e-01 | 0.1534 |
| 79144 | PPDPF | GSM4909312 | Human | Breast | IDC | 6.14e-78 | 6.06e-01 | 0.1552 |
| 79144 | PPDPF | GSM4909313 | Human | Breast | IDC | 9.67e-32 | 4.56e-01 | 0.0391 |
| 79144 | PPDPF | GSM4909315 | Human | Breast | IDC | 2.05e-54 | 5.66e-01 | 0.21 |
| Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Breast |  | IDC: Invasive ductal carcinoma |
| DCIS: Ductal carcinoma in situ | ||
| Precancer(BRCA1-mut): Precancerous lesion from BRCA1 mutation carriers | ||
| Cervix |  | CC: Cervix cancer |
| HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions | ||
| N_HPV: HPV-infected normal cervix | ||
| Colorectum (GSE201348) |  | FAP: Familial adenomatous polyposis |
| CRC: Colorectal cancer | ||
| Colorectum (HTA11) |  | AD: Adenomas |
| SER: Sessile serrated lesions | ||
| MSI-H: Microsatellite-high colorectal cancer | ||
| MSS: Microsatellite stable colorectal cancer | ||
| Endometrium |  | AEH: Atypical endometrial hyperplasia |
| EEC: Endometrioid Cancer | ||
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| GC |  | CAG: Chronic atrophic gastritis |
| CAG with IM: Chronic atrophic gastritis with intestinal metaplasia | ||
| CSG: Chronic superficial gastritis | ||
| GC: Gastric cancer | ||
| SIM: Severe intestinal metaplasia | ||
| WIM: Wild intestinal metaplasia | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma | ||
| Prostate |  | BPH: Benign Prostatic Hyperplasia |
| Skin |  | AK: Actinic keratosis |
| cSCC: Cutaneous squamous cell carcinoma | ||
| SCCIS:squamous cell carcinoma in situ | ||
| Thyroid |  | ATC: Anaplastic thyroid cancer |
| HT: Hashimoto's thyroiditis | ||
| PTC: Papillary thyroid cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| Page: 1 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
Top |
Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| PPDPF | SNV | Missense_Mutation | c.131N>T | p.Pro44Leu | p.P44L | Q9H3Y8 | protein_coding | deleterious(0.02) | possibly_damaging(0.456) | TCGA-E9-A22E-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cyclophosphane | SD | |
| PPDPF | SNV | Missense_Mutation | novel | c.174N>A | p.Phe58Leu | p.F58L | Q9H3Y8 | protein_coding | deleterious(0.04) | benign(0.007) | TCGA-EO-A3AV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | CR |
| PPDPF | SNV | Missense_Mutation | novel | c.80N>G | p.Asn27Ser | p.N27S | Q9H3Y8 | protein_coding | tolerated(0.3) | benign(0.028) | TCGA-DD-AAE3-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
| PPDPF | SNV | Missense_Mutation | c.257N>A | p.Ser86Asn | p.S86N | Q9H3Y8 | protein_coding | tolerated(0.18) | benign(0.003) | TCGA-MI-A75H-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
| PPDPF | SNV | Missense_Mutation | c.164N>T | p.Trp55Leu | p.W55L | Q9H3Y8 | protein_coding | deleterious(0) | possibly_damaging(0.856) | TCGA-64-5815-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Chemotherapy | gemcitabine | CR | |
| PPDPF | SNV | Missense_Mutation | rs759954043 | c.233N>G | p.Ser78Trp | p.S78W | Q9H3Y8 | protein_coding | deleterious(0.02) | possibly_damaging(0.753) | TCGA-NJ-A4YP-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
| PPDPF | SNV | Missense_Mutation | c.136N>G | p.Leu46Val | p.L46V | Q9H3Y8 | protein_coding | tolerated(0.07) | benign(0.292) | TCGA-18-3406-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
| PPDPF | SNV | Missense_Mutation | novel | c.197N>T | p.Pro66Leu | p.P66L | Q9H3Y8 | protein_coding | tolerated(0.08) | probably_damaging(1) | TCGA-CR-5248-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | PD |
| PPDPF | SNV | Missense_Mutation | novel | c.211N>A | p.Val71Met | p.V71M | Q9H3Y8 | protein_coding | deleterious(0.03) | possibly_damaging(0.543) | TCGA-MT-A67F-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| PPDPF | SNV | Missense_Mutation | novel | c.250N>C | p.Ser84Pro | p.S84P | Q9H3Y8 | protein_coding | tolerated(0.18) | benign(0.022) | TCGA-HU-A4GT-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Chemotherapy | copolang | SD |
| Page: 1 |
Top |
Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
Copyright 2023-Present -The University of Texas Health Science Center at Houston |