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Gene: POU6F2 |
Gene summary for POU6F2 |
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Gene information | Species | Human | Gene symbol | POU6F2 | Gene ID | 11281 |
Gene name | POU class 6 homeobox 2 | |
Gene Alias | RPF-1 | |
Cytomap | 7p14.1 | |
Gene Type | protein-coding | GO ID | GO:0001709 | UniProtAcc | P78424 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
11281 | POU6F2 | LZE4T | Human | Esophagus | ESCC | 4.53e-04 | 1.83e-01 | 0.0811 |
11281 | POU6F2 | LZE20T | Human | Esophagus | ESCC | 3.16e-03 | 1.42e-01 | 0.0662 |
11281 | POU6F2 | LZE22T | Human | Esophagus | ESCC | 1.54e-04 | 3.08e-01 | 0.068 |
11281 | POU6F2 | LZE24T | Human | Esophagus | ESCC | 4.99e-09 | 2.05e-01 | 0.0596 |
11281 | POU6F2 | P1T-E | Human | Esophagus | ESCC | 1.05e-09 | 3.99e-01 | 0.0875 |
11281 | POU6F2 | P2T-E | Human | Esophagus | ESCC | 3.87e-34 | 5.27e-01 | 0.1177 |
11281 | POU6F2 | P4T-E | Human | Esophagus | ESCC | 4.59e-20 | 3.81e-01 | 0.1323 |
11281 | POU6F2 | P10T-E | Human | Esophagus | ESCC | 2.06e-08 | 1.66e-01 | 0.116 |
11281 | POU6F2 | P11T-E | Human | Esophagus | ESCC | 2.46e-02 | 1.62e-01 | 0.1426 |
11281 | POU6F2 | P12T-E | Human | Esophagus | ESCC | 4.17e-05 | 1.13e-01 | 0.1122 |
11281 | POU6F2 | P15T-E | Human | Esophagus | ESCC | 2.11e-03 | 1.05e-01 | 0.1149 |
11281 | POU6F2 | P16T-E | Human | Esophagus | ESCC | 1.61e-32 | 5.18e-01 | 0.1153 |
11281 | POU6F2 | P20T-E | Human | Esophagus | ESCC | 3.33e-28 | 5.76e-01 | 0.1124 |
11281 | POU6F2 | P22T-E | Human | Esophagus | ESCC | 2.06e-08 | 1.82e-01 | 0.1236 |
11281 | POU6F2 | P24T-E | Human | Esophagus | ESCC | 3.97e-04 | 1.26e-01 | 0.1287 |
11281 | POU6F2 | P26T-E | Human | Esophagus | ESCC | 2.20e-17 | 3.11e-01 | 0.1276 |
11281 | POU6F2 | P27T-E | Human | Esophagus | ESCC | 1.13e-16 | 3.53e-01 | 0.1055 |
11281 | POU6F2 | P28T-E | Human | Esophagus | ESCC | 7.90e-03 | 9.20e-02 | 0.1149 |
11281 | POU6F2 | P31T-E | Human | Esophagus | ESCC | 4.30e-10 | 1.50e-01 | 0.1251 |
11281 | POU6F2 | P32T-E | Human | Esophagus | ESCC | 2.06e-08 | 1.85e-01 | 0.1666 |
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Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![]() | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
POU6F2 | SNV | Missense_Mutation | c.364N>G | p.Leu122Val | p.L122V | P78424 | protein_coding | deleterious(0.02) | probably_damaging(0.978) | TCGA-B6-A0RG-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
POU6F2 | SNV | Missense_Mutation | novel | c.1750N>A | p.Glu584Lys | p.E584K | P78424 | protein_coding | deleterious(0.01) | probably_damaging(0.995) | TCGA-BH-A0B6-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
POU6F2 | SNV | Missense_Mutation | c.2020N>G | p.Pro674Ala | p.P674A | P78424 | protein_coding | tolerated_low_confidence(1) | benign(0.339) | TCGA-D8-A1XQ-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
POU6F2 | SNV | Missense_Mutation | rs141249466 | c.936G>A | p.Met312Ile | p.M312I | P78424 | protein_coding | tolerated(0.15) | benign(0.023) | TCGA-EW-A1J5-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD |
POU6F2 | deletion | Frame_Shift_Del | novel | c.1232delN | p.Gln411ArgfsTer50 | p.Q411Rfs*50 | P78424 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
POU6F2 | SNV | Missense_Mutation | c.1462N>T | p.Ala488Ser | p.A488S | P78424 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-A6-2680-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
POU6F2 | SNV | Missense_Mutation | rs766931436 | c.614N>T | p.Pro205Leu | p.P205L | P78424 | protein_coding | tolerated_low_confidence(0.14) | benign(0.015) | TCGA-A6-4105-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
POU6F2 | SNV | Missense_Mutation | c.330N>T | p.Met110Ile | p.M110I | P78424 | protein_coding | deleterious(0.03) | benign(0.138) | TCGA-A6-5656-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
POU6F2 | SNV | Missense_Mutation | novel | c.143C>T | p.Ala48Val | p.A48V | P78424 | protein_coding | tolerated_low_confidence(0.69) | benign(0.003) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
POU6F2 | SNV | Missense_Mutation | novel | c.75N>T | p.Met25Ile | p.M25I | P78424 | protein_coding | deleterious_low_confidence(0) | possibly_damaging(0.885) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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