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Gene: POMC |
Gene summary for POMC |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | POMC | Gene ID | 5443 |
| Gene name | proopiomelanocortin | |
| Gene Alias | ACTH | |
| Cytomap | 2p23.3 | |
| Gene Type | protein-coding | GO ID | GO:0001816 | UniProtAcc | P01189 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 5443 | POMC | LZE4T | Human | Esophagus | ESCC | 7.66e-06 | 3.49e-01 | 0.0811 |
| 5443 | POMC | LZE21T | Human | Esophagus | ESCC | 4.07e-08 | 5.98e-01 | 0.0655 |
| 5443 | POMC | P4T-E | Human | Esophagus | ESCC | 7.63e-16 | 4.43e-01 | 0.1323 |
| 5443 | POMC | P9T-E | Human | Esophagus | ESCC | 4.58e-05 | 2.10e-01 | 0.1131 |
| 5443 | POMC | P10T-E | Human | Esophagus | ESCC | 2.69e-06 | 2.17e-01 | 0.116 |
| 5443 | POMC | P12T-E | Human | Esophagus | ESCC | 3.14e-48 | 1.03e+00 | 0.1122 |
| 5443 | POMC | P15T-E | Human | Esophagus | ESCC | 5.71e-38 | 1.43e+00 | 0.1149 |
| 5443 | POMC | P16T-E | Human | Esophagus | ESCC | 2.35e-08 | 2.37e-01 | 0.1153 |
| 5443 | POMC | P26T-E | Human | Esophagus | ESCC | 5.16e-24 | 4.91e-01 | 0.1276 |
| 5443 | POMC | P27T-E | Human | Esophagus | ESCC | 1.36e-28 | 6.75e-01 | 0.1055 |
| 5443 | POMC | P28T-E | Human | Esophagus | ESCC | 4.02e-16 | 3.43e-01 | 0.1149 |
| 5443 | POMC | P30T-E | Human | Esophagus | ESCC | 6.55e-23 | 9.87e-01 | 0.137 |
| 5443 | POMC | P42T-E | Human | Esophagus | ESCC | 3.00e-06 | 2.61e-01 | 0.1175 |
| 5443 | POMC | P48T-E | Human | Esophagus | ESCC | 2.44e-02 | 1.22e-01 | 0.0959 |
| 5443 | POMC | P49T-E | Human | Esophagus | ESCC | 9.52e-22 | 4.09e+00 | 0.1768 |
| 5443 | POMC | P56T-E | Human | Esophagus | ESCC | 7.71e-08 | 1.22e+00 | 0.1613 |
| 5443 | POMC | P74T-E | Human | Esophagus | ESCC | 1.67e-04 | 1.75e-01 | 0.1479 |
| 5443 | POMC | P76T-E | Human | Esophagus | ESCC | 6.70e-08 | 3.07e-01 | 0.1207 |
| 5443 | POMC | P79T-E | Human | Esophagus | ESCC | 1.01e-03 | 1.45e-01 | 0.1154 |
| 5443 | POMC | P107T-E | Human | Esophagus | ESCC | 8.82e-08 | 3.06e-01 | 0.171 |
| Page: 1 2 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:0006091110 | Esophagus | ESCC | generation of precursor metabolites and energy | 331/8552 | 490/18723 | 3.86e-23 | 8.45e-21 | 331 |
| GO:0015980110 | Esophagus | ESCC | energy derivation by oxidation of organic compounds | 220/8552 | 318/18723 | 1.20e-17 | 1.09e-15 | 220 |
| GO:0031667111 | Esophagus | ESCC | response to nutrient levels | 289/8552 | 474/18723 | 9.25e-12 | 3.47e-10 | 289 |
| GO:00059969 | Esophagus | ESCC | monosaccharide metabolic process | 159/8552 | 257/18723 | 1.11e-07 | 1.81e-06 | 159 |
| GO:00193189 | Esophagus | ESCC | hexose metabolic process | 147/8552 | 237/18723 | 2.63e-07 | 3.94e-06 | 147 |
| GO:0043434111 | Esophagus | ESCC | response to peptide hormone | 234/8552 | 414/18723 | 4.93e-06 | 5.21e-05 | 234 |
| GO:00330593 | Esophagus | ESCC | cellular pigmentation | 40/8552 | 53/18723 | 9.67e-06 | 9.21e-05 | 40 |
| GO:00060069 | Esophagus | ESCC | glucose metabolic process | 119/8552 | 196/18723 | 1.51e-05 | 1.36e-04 | 119 |
| GO:004346719 | Esophagus | ESCC | regulation of generation of precursor metabolites and energy | 81/8552 | 130/18723 | 9.58e-05 | 6.81e-04 | 81 |
| GO:00442626 | Esophagus | ESCC | cellular carbohydrate metabolic process | 160/8552 | 283/18723 | 1.43e-04 | 9.66e-04 | 160 |
| GO:00620129 | Esophagus | ESCC | regulation of small molecule metabolic process | 184/8552 | 334/18723 | 3.11e-04 | 1.85e-03 | 184 |
| GO:00109065 | Esophagus | ESCC | regulation of glucose metabolic process | 71/8552 | 119/18723 | 1.46e-03 | 6.92e-03 | 71 |
| GO:00061096 | Esophagus | ESCC | regulation of carbohydrate metabolic process | 101/8552 | 178/18723 | 1.89e-03 | 8.52e-03 | 101 |
| GO:00434731 | Esophagus | ESCC | pigmentation | 59/8552 | 98/18723 | 2.64e-03 | 1.12e-02 | 59 |
| GO:00106755 | Esophagus | ESCC | regulation of cellular carbohydrate metabolic process | 83/8552 | 146/18723 | 4.24e-03 | 1.69e-02 | 83 |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| POMC | SNV | Missense_Mutation | novel | c.323C>T | p.Ser108Leu | p.S108L | P01189 | protein_coding | tolerated(0.09) | benign(0) | TCGA-5L-AAT1-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Hormone Therapy | letrozol | SD |
| POMC | SNV | Missense_Mutation | novel | c.595G>A | p.Ala199Thr | p.A199T | P01189 | protein_coding | tolerated(0.75) | benign(0.007) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
| POMC | SNV | Missense_Mutation | rs766183863 | c.11N>T | p.Ser4Leu | p.S4L | P01189 | protein_coding | tolerated_low_confidence(0.54) | benign(0) | TCGA-FU-A3HZ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
| POMC | SNV | Missense_Mutation | rs758527241 | c.557N>A | p.Arg186Gln | p.R186Q | P01189 | protein_coding | tolerated(0.63) | benign(0.011) | TCGA-LP-A4AU-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | cisplatin | CR |
| POMC | SNV | Missense_Mutation | rs746318172 | c.692N>T | p.Pro231Leu | p.P231L | P01189 | protein_coding | deleterious(0) | probably_damaging(0.916) | TCGA-AA-3492-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| POMC | SNV | Missense_Mutation | rs775998713 | c.755N>T | p.Thr252Met | p.T252M | P01189 | protein_coding | deleterious(0) | probably_damaging(0.958) | TCGA-AA-3966-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| POMC | SNV | Missense_Mutation | novel | c.331N>A | p.Glu111Lys | p.E111K | P01189 | protein_coding | tolerated(0.77) | benign(0.017) | TCGA-WS-AB45-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| POMC | SNV | Missense_Mutation | novel | c.67N>A | p.Glu23Lys | p.E23K | P01189 | protein_coding | tolerated(0.37) | benign(0.326) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
| POMC | SNV | Missense_Mutation | rs146551109 | c.23N>A | p.Arg8His | p.R8H | P01189 | protein_coding | tolerated(0.39) | benign(0.436) | TCGA-AJ-A3EL-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| POMC | SNV | Missense_Mutation | c.508N>A | p.Glu170Lys | p.E170K | P01189 | protein_coding | deleterious(0) | possibly_damaging(0.472) | TCGA-AP-A056-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| Page: 1 2 3 4 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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