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Gene: POGK |
Gene summary for POGK |
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Gene information | Species | Human | Gene symbol | POGK | Gene ID | 57645 |
Gene name | pogo transposable element derived with KRAB domain | |
Gene Alias | BASS2 | |
Cytomap | 1q24.1 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | B4DF62 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
57645 | POGK | LZE4T | Human | Esophagus | ESCC | 1.53e-05 | 1.21e-01 | 0.0811 |
57645 | POGK | LZE7T | Human | Esophagus | ESCC | 2.04e-05 | 4.86e-01 | 0.0667 |
57645 | POGK | LZE8T | Human | Esophagus | ESCC | 1.87e-02 | 2.97e-02 | 0.067 |
57645 | POGK | LZE24T | Human | Esophagus | ESCC | 1.84e-11 | 2.44e-01 | 0.0596 |
57645 | POGK | P2T-E | Human | Esophagus | ESCC | 1.56e-26 | 3.21e-01 | 0.1177 |
57645 | POGK | P4T-E | Human | Esophagus | ESCC | 2.04e-18 | 3.89e-01 | 0.1323 |
57645 | POGK | P5T-E | Human | Esophagus | ESCC | 5.79e-14 | 1.58e-01 | 0.1327 |
57645 | POGK | P8T-E | Human | Esophagus | ESCC | 2.08e-21 | 1.63e-01 | 0.0889 |
57645 | POGK | P9T-E | Human | Esophagus | ESCC | 2.81e-14 | 2.64e-01 | 0.1131 |
57645 | POGK | P10T-E | Human | Esophagus | ESCC | 5.00e-26 | 3.12e-01 | 0.116 |
57645 | POGK | P11T-E | Human | Esophagus | ESCC | 4.67e-02 | 1.31e-01 | 0.1426 |
57645 | POGK | P12T-E | Human | Esophagus | ESCC | 1.23e-17 | 2.05e-01 | 0.1122 |
57645 | POGK | P15T-E | Human | Esophagus | ESCC | 2.44e-16 | 4.12e-01 | 0.1149 |
57645 | POGK | P16T-E | Human | Esophagus | ESCC | 5.74e-15 | 1.83e-01 | 0.1153 |
57645 | POGK | P19T-E | Human | Esophagus | ESCC | 6.25e-03 | 2.84e-01 | 0.1662 |
57645 | POGK | P20T-E | Human | Esophagus | ESCC | 1.78e-12 | 2.22e-01 | 0.1124 |
57645 | POGK | P21T-E | Human | Esophagus | ESCC | 1.50e-13 | 2.41e-01 | 0.1617 |
57645 | POGK | P22T-E | Human | Esophagus | ESCC | 1.42e-10 | 1.96e-01 | 0.1236 |
57645 | POGK | P23T-E | Human | Esophagus | ESCC | 2.24e-16 | 4.46e-01 | 0.108 |
57645 | POGK | P24T-E | Human | Esophagus | ESCC | 4.57e-07 | 1.10e-01 | 0.1287 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
POGK | SNV | Missense_Mutation | novel | c.796N>A | p.Val266Met | p.V266M | Q9P215 | protein_coding | deleterious(0.01) | benign(0.287) | TCGA-5L-AAT1-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Hormone Therapy | letrozol | SD |
POGK | SNV | Missense_Mutation | c.1556G>C | p.Arg519Pro | p.R519P | Q9P215 | protein_coding | deleterious(0.01) | probably_damaging(0.917) | TCGA-BH-A18R-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
POGK | SNV | Missense_Mutation | novel | c.966G>C | p.Arg322Ser | p.R322S | Q9P215 | protein_coding | deleterious(0) | benign(0.289) | TCGA-C8-A8HR-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | 5-fluorouracil | CR |
POGK | insertion | Nonsense_Mutation | novel | c.1213_1214insAAGGCAGGCGTTAATGTTACCC | p.Leu405Ter | p.L405* | Q9P215 | protein_coding | TCGA-A8-A09A-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
POGK | insertion | In_Frame_Ins | novel | c.66_67insGGTTATTTCCCTGTCGGGGTGGGCCCC | p.Gln22_Ser23insGlyTyrPheProValGlyValGlyPro | p.Q22_S23insGYFPVGVGP | Q9P215 | protein_coding | TCGA-A8-A09X-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | ||
POGK | insertion | Nonsense_Mutation | novel | c.775_776insAGCATTCA | p.Phe259Ter | p.F259* | Q9P215 | protein_coding | TCGA-AN-A03Y-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
POGK | SNV | Missense_Mutation | novel | c.1376N>C | p.Gly459Ala | p.G459A | Q9P215 | protein_coding | deleterious(0) | possibly_damaging(0.787) | TCGA-C5-A8XJ-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | cisplatin | SD |
POGK | SNV | Missense_Mutation | c.985N>A | p.Gln329Lys | p.Q329K | Q9P215 | protein_coding | deleterious(0.01) | benign(0.239) | TCGA-DG-A2KH-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
POGK | insertion | Frame_Shift_Ins | novel | c.1087_1088insTTCATTTC | p.Ala363ValfsTer11 | p.A363Vfs*11 | Q9P215 | protein_coding | TCGA-DS-A1OC-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | gemcitabine | SD | ||
POGK | SNV | Missense_Mutation | c.1555N>T | p.Arg519Trp | p.R519W | Q9P215 | protein_coding | deleterious(0.01) | probably_damaging(0.927) | TCGA-AA-3492-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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