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Gene: PODXL2 |
Gene summary for PODXL2 |
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Gene information | Species | Human | Gene symbol | PODXL2 | Gene ID | 50512 |
Gene name | podocalyxin like 2 | |
Gene Alias | EG | |
Cytomap | 3q21.3 | |
Gene Type | protein-coding | GO ID | GO:0002376 | UniProtAcc | Q9NZ53 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
50512 | PODXL2 | LZE2T | Human | Esophagus | ESCC | 6.08e-14 | 8.50e-01 | 0.082 |
50512 | PODXL2 | LZE20T | Human | Esophagus | ESCC | 1.19e-03 | 2.03e-01 | 0.0662 |
50512 | PODXL2 | LZE22T | Human | Esophagus | ESCC | 1.01e-11 | 8.12e-01 | 0.068 |
50512 | PODXL2 | LZE24T | Human | Esophagus | ESCC | 1.38e-45 | 1.13e+00 | 0.0596 |
50512 | PODXL2 | P1T-E | Human | Esophagus | ESCC | 4.46e-09 | 4.90e-01 | 0.0875 |
50512 | PODXL2 | P2T-E | Human | Esophagus | ESCC | 1.58e-53 | 1.09e+00 | 0.1177 |
50512 | PODXL2 | P4T-E | Human | Esophagus | ESCC | 2.13e-14 | 4.21e-01 | 0.1323 |
50512 | PODXL2 | P10T-E | Human | Esophagus | ESCC | 1.58e-51 | 8.80e-01 | 0.116 |
50512 | PODXL2 | P11T-E | Human | Esophagus | ESCC | 9.07e-12 | 6.47e-01 | 0.1426 |
50512 | PODXL2 | P15T-E | Human | Esophagus | ESCC | 1.42e-04 | 1.64e-01 | 0.1149 |
50512 | PODXL2 | P16T-E | Human | Esophagus | ESCC | 6.43e-64 | 1.21e+00 | 0.1153 |
50512 | PODXL2 | P17T-E | Human | Esophagus | ESCC | 2.26e-09 | 5.55e-01 | 0.1278 |
50512 | PODXL2 | P19T-E | Human | Esophagus | ESCC | 3.25e-02 | 2.77e-01 | 0.1662 |
50512 | PODXL2 | P20T-E | Human | Esophagus | ESCC | 2.47e-20 | 5.18e-01 | 0.1124 |
50512 | PODXL2 | P21T-E | Human | Esophagus | ESCC | 2.99e-09 | 2.35e-01 | 0.1617 |
50512 | PODXL2 | P22T-E | Human | Esophagus | ESCC | 2.43e-19 | 3.77e-01 | 0.1236 |
50512 | PODXL2 | P23T-E | Human | Esophagus | ESCC | 7.55e-36 | 9.53e-01 | 0.108 |
50512 | PODXL2 | P24T-E | Human | Esophagus | ESCC | 2.89e-03 | 1.04e-01 | 0.1287 |
50512 | PODXL2 | P26T-E | Human | Esophagus | ESCC | 7.61e-47 | 9.59e-01 | 0.1276 |
50512 | PODXL2 | P27T-E | Human | Esophagus | ESCC | 4.20e-50 | 8.66e-01 | 0.1055 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000715918 | Esophagus | ESCC | leukocyte cell-cell adhesion | 192/8552 | 371/18723 | 1.03e-02 | 3.51e-02 | 192 |
GO:000715916 | Oral cavity | OSCC | leukocyte cell-cell adhesion | 178/7305 | 371/18723 | 2.44e-04 | 1.57e-03 | 178 |
GO:005090010 | Oral cavity | OSCC | leukocyte migration | 176/7305 | 369/18723 | 3.80e-04 | 2.31e-03 | 176 |
GO:000715910 | Prostate | BPH | leukocyte cell-cell adhesion | 86/3107 | 371/18723 | 5.95e-04 | 4.11e-03 | 86 |
GO:00509009 | Prostate | BPH | leukocyte migration | 80/3107 | 369/18723 | 6.09e-03 | 2.80e-02 | 80 |
GO:000715915 | Prostate | Tumor | leukocyte cell-cell adhesion | 89/3246 | 371/18723 | 6.33e-04 | 4.52e-03 | 89 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PODXL2 | SNV | Missense_Mutation | rs540530937 | c.719N>T | p.Gly240Val | p.G240V | Q9NZ53 | protein_coding | deleterious(0.03) | benign(0.102) | TCGA-A7-A0DB-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | arimidex | SD |
PODXL2 | SNV | Missense_Mutation | novel | c.383N>T | p.Gly128Val | p.G128V | Q9NZ53 | protein_coding | tolerated(0.27) | benign(0.003) | TCGA-A8-A06X-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PODXL2 | SNV | Missense_Mutation | c.137N>T | p.Ser46Phe | p.S46F | Q9NZ53 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
PODXL2 | SNV | Missense_Mutation | novel | c.1532N>C | p.Ile511Thr | p.I511T | Q9NZ53 | protein_coding | deleterious(0) | possibly_damaging(0.729) | TCGA-LD-A7W6-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | letrozole | SD |
PODXL2 | SNV | Missense_Mutation | rs764073288 | c.611G>A | p.Arg204His | p.R204H | Q9NZ53 | protein_coding | tolerated(0.55) | benign(0) | TCGA-DG-A2KL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD |
PODXL2 | SNV | Missense_Mutation | rs772993722 | c.901G>A | p.Glu301Lys | p.E301K | Q9NZ53 | protein_coding | tolerated(0.52) | benign(0.017) | TCGA-5M-AAT6-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
PODXL2 | SNV | Missense_Mutation | novel | c.854N>G | p.Ala285Gly | p.A285G | Q9NZ53 | protein_coding | tolerated(0.33) | benign(0) | TCGA-AA-3692-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | folinic | PD |
PODXL2 | SNV | Missense_Mutation | novel | c.1580N>A | p.Arg527His | p.R527H | Q9NZ53 | protein_coding | deleterious(0) | probably_damaging(0.964) | TCGA-AA-3845-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
PODXL2 | SNV | Missense_Mutation | rs749040344 | c.269N>A | p.Arg90Gln | p.R90Q | Q9NZ53 | protein_coding | deleterious(0.01) | benign(0.286) | TCGA-AA-A022-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PODXL2 | SNV | Missense_Mutation | c.629N>C | p.Ser210Thr | p.S210T | Q9NZ53 | protein_coding | tolerated(0.26) | benign(0) | TCGA-AA-A022-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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