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Gene: POC1B |
Gene summary for POC1B |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | POC1B | Gene ID | 282809 |
| Gene name | POC1 centriolar protein B | |
| Gene Alias | CORD20 | |
| Cytomap | 12q21.33 | |
| Gene Type | protein-coding | GO ID | GO:0000226 | UniProtAcc | Q8TC44 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 282809 | POC1B | AEH-subject1 | Human | Endometrium | AEH | 8.93e-12 | 4.21e-01 | -0.3059 |
| 282809 | POC1B | AEH-subject4 | Human | Endometrium | AEH | 9.13e-03 | 2.26e-01 | -0.2657 |
| 282809 | POC1B | AEH-subject5 | Human | Endometrium | AEH | 5.79e-12 | 4.89e-01 | -0.2953 |
| 282809 | POC1B | EEC-subject1 | Human | Endometrium | EEC | 4.14e-03 | 2.92e-01 | -0.2682 |
| 282809 | POC1B | EEC-subject5 | Human | Endometrium | EEC | 3.17e-06 | 3.80e-01 | -0.249 |
| 282809 | POC1B | GSM6177620_NYU_UCEC1_lib1_lib1 | Human | Endometrium | EEC | 8.04e-05 | -5.22e-02 | -0.1869 |
| 282809 | POC1B | GSM6177620_NYU_UCEC1_lib2_lib2 | Human | Endometrium | EEC | 1.93e-08 | -3.16e-02 | -0.1875 |
| 282809 | POC1B | GSM6177620_NYU_UCEC1_lib3_lib3 | Human | Endometrium | EEC | 1.74e-07 | -9.94e-02 | -0.1883 |
| 282809 | POC1B | GSM6177621_NYU_UCEC2_lib1_lib1 | Human | Endometrium | EEC | 2.01e-05 | 1.32e-01 | -0.1934 |
| 282809 | POC1B | GSM6177622_NYU_UCEC3_lib1_lib1 | Human | Endometrium | EEC | 3.42e-06 | -2.43e-02 | -0.1917 |
| 282809 | POC1B | GSM6177622_NYU_UCEC3_lib2_lib2 | Human | Endometrium | EEC | 2.26e-09 | -6.38e-02 | -0.1916 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Endometrium |  | AEH: Atypical endometrial hyperplasia |
| EEC: Endometrioid Cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:000189410 | Endometrium | AEH | tissue homeostasis | 50/2100 | 268/18723 | 2.04e-04 | 2.54e-03 | 50 |
| GO:00602499 | Endometrium | AEH | anatomical structure homeostasis | 55/2100 | 314/18723 | 5.27e-04 | 5.32e-03 | 55 |
| GO:000189415 | Endometrium | EEC | tissue homeostasis | 51/2168 | 268/18723 | 2.34e-04 | 2.75e-03 | 51 |
| GO:006024914 | Endometrium | EEC | anatomical structure homeostasis | 56/2168 | 314/18723 | 6.52e-04 | 6.35e-03 | 56 |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| POC1B | SNV | Missense_Mutation | c.1279G>T | p.Ala427Ser | p.A427S | Q8TC44 | protein_coding | tolerated(0.74) | benign(0.056) | TCGA-A8-A07U-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | 5-fluorouracil | SD | |
| POC1B | SNV | Missense_Mutation | c.1288N>A | p.Asp430Asn | p.D430N | Q8TC44 | protein_coding | tolerated(0.73) | benign(0) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
| POC1B | SNV | Missense_Mutation | rs748606086 | c.1373A>G | p.Asp458Gly | p.D458G | Q8TC44 | protein_coding | deleterious(0.04) | benign(0) | TCGA-B6-A0RQ-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| POC1B | SNV | Missense_Mutation | novel | c.1158N>T | p.Glu386Asp | p.E386D | Q8TC44 | protein_coding | tolerated(0.55) | benign(0) | TCGA-EA-A410-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
| POC1B | SNV | Missense_Mutation | rs774587323 | c.443N>A | p.Arg148His | p.R148H | Q8TC44 | protein_coding | deleterious(0.02) | probably_damaging(0.963) | TCGA-AA-3811-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
| POC1B | SNV | Missense_Mutation | c.887N>C | p.Leu296Ser | p.L296S | Q8TC44 | protein_coding | deleterious(0) | possibly_damaging(0.812) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
| POC1B | SNV | Missense_Mutation | c.511N>G | p.Trp171Gly | p.W171G | Q8TC44 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AA-A022-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| POC1B | SNV | Missense_Mutation | c.1015N>G | p.Lys339Glu | p.K339E | Q8TC44 | protein_coding | tolerated(0.09) | benign(0.129) | TCGA-AD-5900-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
| POC1B | SNV | Missense_Mutation | rs780977321 | c.983N>C | p.Ile328Thr | p.I328T | Q8TC44 | protein_coding | tolerated(0.1) | probably_damaging(0.994) | TCGA-AG-3892-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| POC1B | SNV | Missense_Mutation | rs768581613 | c.1238T>C | p.Met413Thr | p.M413T | Q8TC44 | protein_coding | tolerated(0.41) | benign(0.006) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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