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Gene: PNO1 |
Gene summary for PNO1 |
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Gene information | Species | Human | Gene symbol | PNO1 | Gene ID | 56902 |
Gene name | partner of NOB1 homolog | |
Gene Alias | KHRBP1 | |
Cytomap | 2p14 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q9NRX1 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
56902 | PNO1 | LZE4T | Human | Esophagus | ESCC | 9.13e-04 | 2.01e-01 | 0.0811 |
56902 | PNO1 | LZE7T | Human | Esophagus | ESCC | 4.44e-02 | 1.83e-01 | 0.0667 |
56902 | PNO1 | LZE8T | Human | Esophagus | ESCC | 3.50e-02 | -3.64e-02 | 0.067 |
56902 | PNO1 | LZE24T | Human | Esophagus | ESCC | 1.41e-10 | 2.59e-01 | 0.0596 |
56902 | PNO1 | P1T-E | Human | Esophagus | ESCC | 1.62e-04 | 1.17e-01 | 0.0875 |
56902 | PNO1 | P2T-E | Human | Esophagus | ESCC | 1.49e-30 | 6.38e-01 | 0.1177 |
56902 | PNO1 | P4T-E | Human | Esophagus | ESCC | 2.06e-12 | 6.55e-01 | 0.1323 |
56902 | PNO1 | P5T-E | Human | Esophagus | ESCC | 5.77e-24 | 6.25e-01 | 0.1327 |
56902 | PNO1 | P8T-E | Human | Esophagus | ESCC | 4.23e-13 | 8.86e-02 | 0.0889 |
56902 | PNO1 | P9T-E | Human | Esophagus | ESCC | 2.57e-07 | 3.35e-01 | 0.1131 |
56902 | PNO1 | P10T-E | Human | Esophagus | ESCC | 1.22e-16 | 3.01e-01 | 0.116 |
56902 | PNO1 | P11T-E | Human | Esophagus | ESCC | 9.77e-05 | 3.14e-01 | 0.1426 |
56902 | PNO1 | P12T-E | Human | Esophagus | ESCC | 3.76e-20 | 4.01e-01 | 0.1122 |
56902 | PNO1 | P15T-E | Human | Esophagus | ESCC | 1.06e-24 | 4.77e-01 | 0.1149 |
56902 | PNO1 | P16T-E | Human | Esophagus | ESCC | 1.00e-19 | 4.91e-01 | 0.1153 |
56902 | PNO1 | P17T-E | Human | Esophagus | ESCC | 1.71e-08 | 2.08e-01 | 0.1278 |
56902 | PNO1 | P19T-E | Human | Esophagus | ESCC | 5.19e-04 | 9.18e-01 | 0.1662 |
56902 | PNO1 | P20T-E | Human | Esophagus | ESCC | 1.71e-08 | 4.10e-01 | 0.1124 |
56902 | PNO1 | P21T-E | Human | Esophagus | ESCC | 7.21e-23 | 6.05e-01 | 0.1617 |
56902 | PNO1 | P22T-E | Human | Esophagus | ESCC | 6.00e-21 | 3.54e-01 | 0.1236 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PNO1 | SNV | Missense_Mutation | c.748N>T | p.Asp250Tyr | p.D250Y | Q9NRX1 | protein_coding | deleterious(0) | possibly_damaging(0.702) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
PNO1 | SNV | Missense_Mutation | novel | c.362N>C | p.Cys121Ser | p.C121S | Q9NRX1 | protein_coding | tolerated(1) | benign(0.015) | TCGA-AC-A2BK-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | cytoxan | CR |
PNO1 | SNV | Missense_Mutation | rs544947906 | c.539T>C | p.Ile180Thr | p.I180T | Q9NRX1 | protein_coding | deleterious(0) | probably_damaging(0.955) | TCGA-A6-2682-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | 5 | PD |
PNO1 | SNV | Missense_Mutation | novel | c.441G>T | p.Glu147Asp | p.E147D | Q9NRX1 | protein_coding | tolerated(0.83) | benign(0.015) | TCGA-AA-3950-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PNO1 | SNV | Missense_Mutation | rs868718983 | c.137G>A | p.Arg46His | p.R46H | Q9NRX1 | protein_coding | tolerated(0.18) | benign(0) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
PNO1 | SNV | Missense_Mutation | c.355N>G | p.Arg119Gly | p.R119G | Q9NRX1 | protein_coding | deleterious(0) | possibly_damaging(0.691) | TCGA-AA-A01R-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5-fluorouracil | PD | |
PNO1 | SNV | Missense_Mutation | rs755917828 | c.412N>G | p.Lys138Glu | p.K138E | Q9NRX1 | protein_coding | deleterious(0.03) | possibly_damaging(0.506) | TCGA-CK-6746-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PNO1 | SNV | Missense_Mutation | c.310G>A | p.Gly104Arg | p.G104R | Q9NRX1 | protein_coding | tolerated(0.13) | benign(0.003) | TCGA-DY-A1DF-01 | Colorectum | rectum adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
PNO1 | SNV | Missense_Mutation | novel | c.112N>A | p.Ala38Thr | p.A38T | Q9NRX1 | protein_coding | tolerated(0.39) | benign(0) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
PNO1 | SNV | Missense_Mutation | rs766561587 | c.596G>A | p.Arg199Gln | p.R199Q | Q9NRX1 | protein_coding | tolerated(0.06) | possibly_damaging(0.523) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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