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Gene: PNMA5 |
Gene summary for PNMA5 |
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Gene information | Species | Human | Gene symbol | PNMA5 | Gene ID | 114824 |
Gene name | PNMA family member 5 | |
Gene Alias | PNMA5 | |
Cytomap | Xq28 | |
Gene Type | protein-coding | GO ID | GO:0006915 | UniProtAcc | Q96PV4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
114824 | PNMA5 | Tumor | Human | Cervix | CC | 3.92e-37 | 5.70e-01 | 0.1241 |
114824 | PNMA5 | sample3 | Human | Cervix | CC | 1.41e-43 | 6.16e-01 | 0.1387 |
114824 | PNMA5 | T3 | Human | Cervix | CC | 1.41e-43 | 5.83e-01 | 0.1389 |
114824 | PNMA5 | S014 | Human | Liver | HCC | 5.01e-63 | 1.83e+00 | 0.2254 |
114824 | PNMA5 | S015 | Human | Liver | HCC | 3.21e-48 | 1.56e+00 | 0.2375 |
114824 | PNMA5 | S016 | Human | Liver | HCC | 3.70e-67 | 1.63e+00 | 0.2243 |
114824 | PNMA5 | ATC09 | Human | Thyroid | ATC | 2.07e-20 | 5.48e-01 | 0.2871 |
114824 | PNMA5 | ATC1 | Human | Thyroid | ATC | 3.66e-21 | 6.03e-01 | 0.2878 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PNMA5 | SNV | Missense_Mutation | c.268N>A | p.Glu90Lys | p.E90K | Q96PV4 | protein_coding | tolerated(0.1) | benign(0.053) | TCGA-AO-A0JD-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cyclophosphamide | SD | |
PNMA5 | SNV | Missense_Mutation | novel | c.785T>C | p.Phe262Ser | p.F262S | Q96PV4 | protein_coding | deleterious(0) | possibly_damaging(0.84) | TCGA-B6-A2IU-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
PNMA5 | SNV | Missense_Mutation | rs781928740 | c.940N>C | p.Cys314Arg | p.C314R | Q96PV4 | protein_coding | tolerated(0.83) | benign(0.005) | TCGA-BH-A18G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PNMA5 | insertion | Frame_Shift_Ins | novel | c.802_803insATACAGGGAGGCTTACCCCCATTAGTGAAACGCAGGCG | p.Pro268HisfsTer32 | p.P268Hfs*32 | Q96PV4 | protein_coding | TCGA-A8-A09B-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | 5-fluorouracil | SD | ||
PNMA5 | SNV | Missense_Mutation | c.638N>A | p.Arg213Gln | p.R213Q | Q96PV4 | protein_coding | tolerated(0.2) | benign(0.036) | TCGA-EA-A5ZF-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD | |
PNMA5 | SNV | Missense_Mutation | c.1270N>A | p.Pro424Thr | p.P424T | Q96PV4 | protein_coding | tolerated(0.2) | benign(0.012) | TCGA-EK-A2PM-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD | |
PNMA5 | SNV | Missense_Mutation | c.552N>C | p.Glu184Asp | p.E184D | Q96PV4 | protein_coding | tolerated(0.12) | benign(0.014) | TCGA-HM-A4S6-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | cisplatin | CR | |
PNMA5 | SNV | Missense_Mutation | c.890N>T | p.Ala297Val | p.A297V | Q96PV4 | protein_coding | tolerated(0.06) | benign(0) | TCGA-AA-3715-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
PNMA5 | SNV | Missense_Mutation | c.1118N>A | p.Ser373Tyr | p.S373Y | Q96PV4 | protein_coding | tolerated(1) | benign(0) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
PNMA5 | SNV | Missense_Mutation | rs782287773 | c.488N>T | p.Ser163Leu | p.S163L | Q96PV4 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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