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Gene: PNCK |
Gene summary for PNCK |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | PNCK | Gene ID | 139728 |
| Gene name | pregnancy up-regulated nonubiquitous CaM kinase | |
| Gene Alias | BSTK3 | |
| Cytomap | Xq28 | |
| Gene Type | protein-coding | GO ID | GO:0006464 | UniProtAcc | Q6P2M8 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 139728 | PNCK | LZE4T | Human | Esophagus | ESCC | 6.35e-03 | 1.62e-01 | 0.0811 |
| 139728 | PNCK | LZE7T | Human | Esophagus | ESCC | 2.56e-05 | 3.99e-01 | 0.0667 |
| 139728 | PNCK | LZE8T | Human | Esophagus | ESCC | 4.41e-02 | 1.21e-01 | 0.067 |
| 139728 | PNCK | LZE20T | Human | Esophagus | ESCC | 5.57e-10 | 4.09e-01 | 0.0662 |
| 139728 | PNCK | LZE22T | Human | Esophagus | ESCC | 1.57e-03 | 3.36e-01 | 0.068 |
| 139728 | PNCK | P2T-E | Human | Esophagus | ESCC | 7.98e-13 | 3.52e-01 | 0.1177 |
| 139728 | PNCK | P4T-E | Human | Esophagus | ESCC | 2.45e-12 | 3.34e-01 | 0.1323 |
| 139728 | PNCK | P5T-E | Human | Esophagus | ESCC | 1.46e-28 | 6.03e-01 | 0.1327 |
| 139728 | PNCK | P9T-E | Human | Esophagus | ESCC | 1.08e-07 | 2.47e-01 | 0.1131 |
| 139728 | PNCK | P10T-E | Human | Esophagus | ESCC | 7.31e-14 | 3.38e-01 | 0.116 |
| 139728 | PNCK | P15T-E | Human | Esophagus | ESCC | 5.19e-07 | 1.97e-01 | 0.1149 |
| 139728 | PNCK | P26T-E | Human | Esophagus | ESCC | 6.03e-56 | 1.58e+00 | 0.1276 |
| 139728 | PNCK | P28T-E | Human | Esophagus | ESCC | 7.32e-38 | 7.48e-01 | 0.1149 |
| 139728 | PNCK | P37T-E | Human | Esophagus | ESCC | 5.37e-05 | 1.89e-01 | 0.1371 |
| 139728 | PNCK | P44T-E | Human | Esophagus | ESCC | 4.95e-07 | 2.73e-01 | 0.1096 |
| 139728 | PNCK | P47T-E | Human | Esophagus | ESCC | 9.35e-10 | 2.66e-01 | 0.1067 |
| 139728 | PNCK | P49T-E | Human | Esophagus | ESCC | 6.53e-04 | 2.82e-01 | 0.1768 |
| 139728 | PNCK | P54T-E | Human | Esophagus | ESCC | 7.62e-03 | 1.23e-01 | 0.0975 |
| 139728 | PNCK | P56T-E | Human | Esophagus | ESCC | 1.10e-03 | 4.15e-01 | 0.1613 |
| 139728 | PNCK | P62T-E | Human | Esophagus | ESCC | 2.57e-02 | 1.05e-01 | 0.1302 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:00182099 | Esophagus | ESCC | peptidyl-serine modification | 196/8552 | 338/18723 | 3.07e-06 | 3.47e-05 | 196 |
| GO:001810515 | Esophagus | ESCC | peptidyl-serine phosphorylation | 184/8552 | 315/18723 | 3.22e-06 | 3.61e-05 | 184 |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| PNCK | SNV | Missense_Mutation | c.542N>C | p.Leu181Pro | p.L181P | Q6P2M8 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A2-A04P-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | taxol | PD | |
| PNCK | SNV | Missense_Mutation | c.461N>T | p.Pro154Leu | p.P154L | Q6P2M8 | protein_coding | deleterious(0) | possibly_damaging(0.812) | TCGA-A8-A09Z-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| PNCK | SNV | Missense_Mutation | novel | c.968N>T | p.Ser323Leu | p.S323L | Q6P2M8 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-BH-A0B6-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| PNCK | SNV | Missense_Mutation | rs782013647 | c.847N>A | p.Val283Ile | p.V283I | Q6P2M8 | protein_coding | tolerated(0.06) | benign(0.007) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
| PNCK | SNV | Missense_Mutation | novel | c.329N>T | p.Ser110Phe | p.S110F | Q6P2M8 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-C5-A8XJ-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | cisplatin | SD |
| PNCK | SNV | Missense_Mutation | c.1234N>A | p.Arg412Ser | p.R412S | Q6P2M8 | protein_coding | tolerated(0.19) | benign(0.003) | TCGA-EK-A2PM-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD | |
| PNCK | SNV | Missense_Mutation | c.370N>A | p.Val124Met | p.V124M | Q6P2M8 | protein_coding | tolerated(0.05) | probably_damaging(0.998) | TCGA-MU-A51Y-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
| PNCK | SNV | Missense_Mutation | novel | c.719N>C | p.Asp240Ala | p.D240A | Q6P2M8 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| PNCK | SNV | Missense_Mutation | c.1208N>T | p.Glu403Val | p.E403V | Q6P2M8 | protein_coding | deleterious(0.01) | possibly_damaging(0.9) | TCGA-CM-5861-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
| PNCK | SNV | Missense_Mutation | novel | c.1082G>T | p.Arg361Met | p.R361M | Q6P2M8 | protein_coding | deleterious(0.02) | possibly_damaging(0.617) | TCGA-AF-2691-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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