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Gene: PM20D2 |
Gene summary for PM20D2 |
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Gene information | Species | Human | Gene symbol | PM20D2 | Gene ID | 135293 |
Gene name | peptidase M20 domain containing 2 | |
Gene Alias | ACY1L2 | |
Cytomap | 6q15 | |
Gene Type | protein-coding | GO ID | GO:0006508 | UniProtAcc | Q8IYS1 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
135293 | PM20D2 | LZE4T | Human | Esophagus | ESCC | 8.22e-09 | 1.43e-01 | 0.0811 |
135293 | PM20D2 | LZE21T | Human | Esophagus | ESCC | 1.63e-05 | 1.55e-01 | 0.0655 |
135293 | PM20D2 | P2T-E | Human | Esophagus | ESCC | 3.35e-15 | 2.56e-01 | 0.1177 |
135293 | PM20D2 | P4T-E | Human | Esophagus | ESCC | 2.90e-16 | 3.16e-01 | 0.1323 |
135293 | PM20D2 | P5T-E | Human | Esophagus | ESCC | 1.57e-05 | 1.14e-01 | 0.1327 |
135293 | PM20D2 | P8T-E | Human | Esophagus | ESCC | 2.99e-12 | 2.72e-01 | 0.0889 |
135293 | PM20D2 | P9T-E | Human | Esophagus | ESCC | 2.04e-08 | 5.02e-02 | 0.1131 |
135293 | PM20D2 | P10T-E | Human | Esophagus | ESCC | 2.81e-15 | 2.95e-01 | 0.116 |
135293 | PM20D2 | P11T-E | Human | Esophagus | ESCC | 2.77e-02 | 1.67e-01 | 0.1426 |
135293 | PM20D2 | P12T-E | Human | Esophagus | ESCC | 5.57e-22 | 4.44e-01 | 0.1122 |
135293 | PM20D2 | P15T-E | Human | Esophagus | ESCC | 7.79e-14 | 2.42e-01 | 0.1149 |
135293 | PM20D2 | P16T-E | Human | Esophagus | ESCC | 8.12e-19 | 3.95e-01 | 0.1153 |
135293 | PM20D2 | P17T-E | Human | Esophagus | ESCC | 2.30e-06 | 1.08e-01 | 0.1278 |
135293 | PM20D2 | P20T-E | Human | Esophagus | ESCC | 2.63e-02 | 1.56e-02 | 0.1124 |
135293 | PM20D2 | P21T-E | Human | Esophagus | ESCC | 5.53e-09 | 2.74e-01 | 0.1617 |
135293 | PM20D2 | P22T-E | Human | Esophagus | ESCC | 3.52e-06 | 1.19e-01 | 0.1236 |
135293 | PM20D2 | P23T-E | Human | Esophagus | ESCC | 2.91e-10 | 1.43e-01 | 0.108 |
135293 | PM20D2 | P24T-E | Human | Esophagus | ESCC | 5.06e-09 | 1.34e-01 | 0.1287 |
135293 | PM20D2 | P26T-E | Human | Esophagus | ESCC | 2.62e-11 | 1.35e-01 | 0.1276 |
135293 | PM20D2 | P27T-E | Human | Esophagus | ESCC | 3.43e-10 | 1.73e-01 | 0.1055 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PM20D2 | SNV | Missense_Mutation | c.1138C>G | p.Gln380Glu | p.Q380E | Q8IYS1 | protein_coding | tolerated(1) | benign(0.001) | TCGA-A8-A07W-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | exemestane | SD | |
PM20D2 | SNV | Missense_Mutation | c.1125N>C | p.Leu375Phe | p.L375F | Q8IYS1 | protein_coding | tolerated(0.13) | benign(0.063) | TCGA-AO-A0J4-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | |
PM20D2 | SNV | Missense_Mutation | c.578N>G | p.Glu193Gly | p.E193G | Q8IYS1 | protein_coding | tolerated(0.37) | possibly_damaging(0.636) | TCGA-B6-A0IJ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
PM20D2 | SNV | Missense_Mutation | c.716C>T | p.Ser239Phe | p.S239F | Q8IYS1 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-DR-A0ZM-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unspecific | Cisplatin | SD | |
PM20D2 | insertion | Frame_Shift_Ins | novel | c.1142_1143insTACT | p.Glu383HisfsTer2 | p.E383Hfs*2 | Q8IYS1 | protein_coding | TCGA-FU-A3WB-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | ||
PM20D2 | SNV | Missense_Mutation | c.725N>C | p.Arg242Thr | p.R242T | Q8IYS1 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AA-3852-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
PM20D2 | SNV | Missense_Mutation | rs758498787 | c.1186C>T | p.Arg396Trp | p.R396W | Q8IYS1 | protein_coding | deleterious(0.01) | probably_damaging(0.919) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
PM20D2 | SNV | Missense_Mutation | c.1223N>C | p.Val408Ala | p.V408A | Q8IYS1 | protein_coding | deleterious(0.03) | benign(0.245) | TCGA-CA-6718-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD | |
PM20D2 | SNV | Missense_Mutation | novel | c.1058A>G | p.Asp353Gly | p.D353G | Q8IYS1 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
PM20D2 | deletion | Frame_Shift_Del | c.862delN | p.Lys289ArgfsTer46 | p.K289Rfs*46 | Q8IYS1 | protein_coding | TCGA-A6-5661-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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