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Gene: PLXNB2 |
Gene summary for PLXNB2 |
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Gene information | Species | Human | Gene symbol | PLXNB2 | Gene ID | 23654 |
Gene name | plexin B2 | |
Gene Alias | MM1 | |
Cytomap | 22q13.33 | |
Gene Type | protein-coding | GO ID | GO:0000902 | UniProtAcc | O15031 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23654 | PLXNB2 | HTA11_3410_2000001011 | Human | Colorectum | AD | 4.55e-06 | 1.98e-01 | 0.0155 |
23654 | PLXNB2 | HTA11_2487_2000001011 | Human | Colorectum | SER | 6.87e-23 | 9.48e-01 | -0.1808 |
23654 | PLXNB2 | HTA11_1938_2000001011 | Human | Colorectum | AD | 2.85e-10 | 5.11e-01 | -0.0811 |
23654 | PLXNB2 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.05e-13 | 3.60e-01 | -0.1954 |
23654 | PLXNB2 | HTA11_411_2000001011 | Human | Colorectum | SER | 5.32e-09 | 1.51e+00 | -0.2602 |
23654 | PLXNB2 | HTA11_2112_2000001011 | Human | Colorectum | SER | 4.73e-05 | 7.76e-01 | -0.2196 |
23654 | PLXNB2 | HTA11_3361_2000001011 | Human | Colorectum | AD | 5.20e-09 | 5.53e-01 | -0.1207 |
23654 | PLXNB2 | HTA11_83_2000001011 | Human | Colorectum | SER | 2.12e-04 | 4.01e-01 | -0.1526 |
23654 | PLXNB2 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.11e-13 | 5.89e-01 | -0.1464 |
23654 | PLXNB2 | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.10e-18 | 7.26e-01 | -0.059 |
23654 | PLXNB2 | HTA11_5212_2000001011 | Human | Colorectum | AD | 8.12e-07 | 4.80e-01 | -0.2061 |
23654 | PLXNB2 | HTA11_5216_2000001011 | Human | Colorectum | SER | 4.28e-04 | 4.91e-01 | -0.1462 |
23654 | PLXNB2 | HTA11_546_2000001011 | Human | Colorectum | AD | 1.52e-02 | 2.88e-01 | -0.0842 |
23654 | PLXNB2 | HTA11_866_3004761011 | Human | Colorectum | AD | 6.37e-18 | 4.56e-01 | 0.096 |
23654 | PLXNB2 | HTA11_10711_2000001011 | Human | Colorectum | AD | 5.17e-03 | 2.64e-01 | 0.0338 |
23654 | PLXNB2 | HTA11_6818_2000001011 | Human | Colorectum | AD | 5.03e-08 | 4.84e-01 | 0.0112 |
23654 | PLXNB2 | HTA11_6818_2000001021 | Human | Colorectum | AD | 4.13e-05 | 3.33e-01 | 0.0588 |
23654 | PLXNB2 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 1.56e-04 | 2.79e-01 | 0.281 |
23654 | PLXNB2 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 5.66e-07 | 4.60e-01 | 0.3859 |
23654 | PLXNB2 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 1.25e-08 | 4.31e-01 | 0.3005 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0022604 | Colorectum | AD | regulation of cell morphogenesis | 109/3918 | 309/18723 | 3.08e-09 | 2.07e-07 | 109 |
GO:0034329 | Colorectum | AD | cell junction assembly | 136/3918 | 420/18723 | 2.02e-08 | 1.15e-06 | 136 |
GO:0006417 | Colorectum | AD | regulation of translation | 141/3918 | 468/18723 | 1.32e-06 | 4.22e-05 | 141 |
GO:0043087 | Colorectum | AD | regulation of GTPase activity | 110/3918 | 348/18723 | 1.64e-06 | 5.03e-05 | 110 |
GO:0008360 | Colorectum | AD | regulation of cell shape | 56/3918 | 154/18723 | 7.01e-06 | 1.73e-04 | 56 |
GO:0010975 | Colorectum | AD | regulation of neuron projection development | 129/3918 | 445/18723 | 2.88e-05 | 5.37e-04 | 129 |
GO:0007409 | Colorectum | AD | axonogenesis | 122/3918 | 418/18723 | 3.36e-05 | 6.15e-04 | 122 |
GO:0031346 | Colorectum | AD | positive regulation of cell projection organization | 104/3918 | 353/18723 | 8.26e-05 | 1.30e-03 | 104 |
GO:0061564 | Colorectum | AD | axon development | 132/3918 | 467/18723 | 8.40e-05 | 1.31e-03 | 132 |
GO:0034250 | Colorectum | AD | positive regulation of cellular amide metabolic process | 53/3918 | 162/18723 | 2.98e-04 | 3.60e-03 | 53 |
GO:0010720 | Colorectum | AD | positive regulation of cell development | 87/3918 | 298/18723 | 4.17e-04 | 4.71e-03 | 87 |
GO:0060562 | Colorectum | AD | epithelial tube morphogenesis | 93/3918 | 325/18723 | 5.65e-04 | 6.00e-03 | 93 |
GO:0045727 | Colorectum | AD | positive regulation of translation | 45/3918 | 136/18723 | 6.24e-04 | 6.48e-03 | 45 |
GO:0050770 | Colorectum | AD | regulation of axonogenesis | 49/3918 | 154/18723 | 9.88e-04 | 9.28e-03 | 49 |
GO:0014020 | Colorectum | AD | primary neural tube formation | 33/3918 | 94/18723 | 1.02e-03 | 9.50e-03 | 33 |
GO:0001841 | Colorectum | AD | neural tube formation | 35/3918 | 102/18723 | 1.16e-03 | 1.05e-02 | 35 |
GO:0050767 | Colorectum | AD | regulation of neurogenesis | 99/3918 | 364/18723 | 2.35e-03 | 1.82e-02 | 99 |
GO:0001843 | Colorectum | AD | neural tube closure | 30/3918 | 88/18723 | 2.83e-03 | 2.12e-02 | 30 |
GO:0060606 | Colorectum | AD | tube closure | 30/3918 | 89/18723 | 3.42e-03 | 2.49e-02 | 30 |
GO:0035148 | Colorectum | AD | tube formation | 45/3918 | 148/18723 | 4.13e-03 | 2.87e-02 | 45 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa04360 | Colorectum | AD | Axon guidance | 61/2092 | 182/8465 | 4.36e-03 | 2.17e-02 | 1.38e-02 | 61 |
hsa043601 | Colorectum | AD | Axon guidance | 61/2092 | 182/8465 | 4.36e-03 | 2.17e-02 | 1.38e-02 | 61 |
hsa043602 | Colorectum | MSS | Axon guidance | 54/1875 | 182/8465 | 1.03e-02 | 3.69e-02 | 2.26e-02 | 54 |
hsa043603 | Colorectum | MSS | Axon guidance | 54/1875 | 182/8465 | 1.03e-02 | 3.69e-02 | 2.26e-02 | 54 |
hsa0436016 | Esophagus | ESCC | Axon guidance | 108/4205 | 182/8465 | 5.13e-03 | 1.30e-02 | 6.67e-03 | 108 |
hsa0436017 | Esophagus | ESCC | Axon guidance | 108/4205 | 182/8465 | 5.13e-03 | 1.30e-02 | 6.67e-03 | 108 |
hsa0436014 | Oral cavity | OSCC | Axon guidance | 97/3704 | 182/8465 | 5.59e-03 | 1.33e-02 | 6.76e-03 | 97 |
hsa0436015 | Oral cavity | OSCC | Axon guidance | 97/3704 | 182/8465 | 5.59e-03 | 1.33e-02 | 6.76e-03 | 97 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
SEMA4A | PLXNB2 | SEMA4A_PLXNB2 | SEMA4 | Breast | DCIS |
SEMA4D | PLXNB2 | SEMA4D_PLXNB2 | SEMA4 | Breast | DCIS |
SEMA4D | PLXNB2 | SEMA4D_PLXNB2 | SEMA4 | Breast | Healthy |
SEMA4D | PLXNB2 | SEMA4D_PLXNB2 | SEMA4 | Breast | IDC |
SEMA4A | PLXNB2 | SEMA4A_PLXNB2 | SEMA4 | Cervix | ADJ |
SEMA4D | PLXNB2 | SEMA4D_PLXNB2 | SEMA4 | Cervix | ADJ |
SEMA4A | PLXNB2 | SEMA4A_PLXNB2 | SEMA4 | Cervix | CC |
SEMA4D | PLXNB2 | SEMA4D_PLXNB2 | SEMA4 | Cervix | CC |
SEMA4D | PLXNB2 | SEMA4D_PLXNB2 | SEMA4 | Cervix | Healthy |
SEMA4D | PLXNB2 | SEMA4D_PLXNB2 | SEMA4 | Cervix | Precancer |
SEMA4A | PLXNB2 | SEMA4A_PLXNB2 | SEMA4 | CRC | ADJ |
SEMA4D | PLXNB2 | SEMA4D_PLXNB2 | SEMA4 | CRC | ADJ |
SEMA4D | PLXNB2 | SEMA4D_PLXNB2 | SEMA4 | CRC | FAP |
SEMA4A | PLXNB2 | SEMA4A_PLXNB2 | SEMA4 | CRC | MSI-H |
SEMA4D | PLXNB2 | SEMA4D_PLXNB2 | SEMA4 | CRC | MSI-H |
SEMA4C | PLXNB2 | SEMA4C_PLXNB2 | SEMA4 | CRC | MSI-H |
SEMA4D | PLXNB2 | SEMA4D_PLXNB2 | SEMA4 | CRC | MSS |
SEMA4C | PLXNB2 | SEMA4C_PLXNB2 | SEMA4 | CRC | MSS |
SEMA4A | PLXNB2 | SEMA4A_PLXNB2 | SEMA4 | CRC | SER |
SEMA4D | PLXNB2 | SEMA4D_PLXNB2 | SEMA4 | CRC | SER |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PLXNB2 | SNV | Missense_Mutation | c.3109N>T | p.Pro1037Ser | p.P1037S | O15031 | protein_coding | tolerated(0.39) | benign(0) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
PLXNB2 | SNV | Missense_Mutation | novel | c.2651N>T | p.Ser884Leu | p.S884L | O15031 | protein_coding | deleterious(0.01) | probably_damaging(0.93) | TCGA-AQ-A54N-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PLXNB2 | SNV | Missense_Mutation | c.4957N>A | p.Ala1653Thr | p.A1653T | O15031 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-BH-A18G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
PLXNB2 | SNV | Missense_Mutation | rs554117465 | c.857N>T | p.Ala286Val | p.A286V | O15031 | protein_coding | tolerated(0.34) | benign(0.001) | TCGA-BH-A18G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PLXNB2 | SNV | Missense_Mutation | c.3805G>A | p.Glu1269Lys | p.E1269K | O15031 | protein_coding | tolerated(0.14) | probably_damaging(0.993) | TCGA-BH-A1FM-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
PLXNB2 | SNV | Missense_Mutation | rs747432493 | c.2459N>A | p.Arg820His | p.R820H | O15031 | protein_coding | tolerated(0.17) | benign(0.04) | TCGA-EW-A1IZ-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | taxotere | SD |
PLXNB2 | SNV | Missense_Mutation | c.4275N>G | p.Phe1425Leu | p.F1425L | O15031 | protein_coding | deleterious(0) | possibly_damaging(0.84) | TCGA-GM-A2D9-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD | |
PLXNB2 | SNV | Missense_Mutation | c.2296N>A | p.Asp766Asn | p.D766N | O15031 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-XX-A89A-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
PLXNB2 | deletion | Frame_Shift_Del | novel | c.3776delA | p.Glu1259GlyfsTer38 | p.E1259Gfs*38 | O15031 | protein_coding | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD | ||
PLXNB2 | SNV | Missense_Mutation | c.445N>A | p.Glu149Lys | p.E149K | O15031 | protein_coding | tolerated(0.06) | possibly_damaging(0.799) | TCGA-DR-A0ZM-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unspecific | Cisplatin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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