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Gene: PLXDC2 |
Gene summary for PLXDC2 |
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Gene information | Species | Human | Gene symbol | PLXDC2 | Gene ID | 84898 |
Gene name | plexin domain containing 2 | |
Gene Alias | TEM7R | |
Cytomap | 10p12.31 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q6UX71 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
84898 | PLXDC2 | CA_HPV_1 | Human | Cervix | CC | 7.03e-03 | 1.21e-01 | 0.0264 |
84898 | PLXDC2 | CCI_3 | Human | Cervix | CC | 2.41e-14 | 1.35e+00 | 0.516 |
84898 | PLXDC2 | Tumor | Human | Cervix | CC | 2.32e-16 | -3.25e-01 | 0.1241 |
84898 | PLXDC2 | sample3 | Human | Cervix | CC | 5.24e-16 | -3.25e-01 | 0.1387 |
84898 | PLXDC2 | H2 | Human | Cervix | HSIL_HPV | 5.63e-07 | -2.63e-01 | 0.0632 |
84898 | PLXDC2 | T3 | Human | Cervix | CC | 2.04e-12 | -3.23e-01 | 0.1389 |
84898 | PLXDC2 | HTA11_3410_2000001011 | Human | Colorectum | AD | 2.83e-30 | -9.09e-01 | 0.0155 |
84898 | PLXDC2 | HTA11_2487_2000001011 | Human | Colorectum | SER | 7.14e-04 | -5.40e-01 | -0.1808 |
84898 | PLXDC2 | HTA11_1938_2000001011 | Human | Colorectum | AD | 1.06e-03 | -5.53e-01 | -0.0811 |
84898 | PLXDC2 | HTA11_347_2000001011 | Human | Colorectum | AD | 4.03e-08 | 5.78e-01 | -0.1954 |
84898 | PLXDC2 | HTA11_5212_2000001011 | Human | Colorectum | AD | 1.32e-05 | -7.30e-01 | -0.2061 |
84898 | PLXDC2 | HTA11_866_3004761011 | Human | Colorectum | AD | 8.76e-29 | -8.69e-01 | 0.096 |
84898 | PLXDC2 | HTA11_9408_2000001011 | Human | Colorectum | AD | 9.46e-07 | -1.05e+00 | 0.0451 |
84898 | PLXDC2 | HTA11_8622_2000001021 | Human | Colorectum | SER | 2.90e-03 | -5.95e-01 | 0.0528 |
84898 | PLXDC2 | HTA11_6801_2000001011 | Human | Colorectum | SER | 2.27e-02 | -6.94e-01 | 0.0171 |
84898 | PLXDC2 | HTA11_10711_2000001011 | Human | Colorectum | AD | 4.11e-16 | -8.13e-01 | 0.0338 |
84898 | PLXDC2 | HTA11_7696_3000711011 | Human | Colorectum | AD | 5.31e-50 | -1.01e+00 | 0.0674 |
84898 | PLXDC2 | HTA11_6818_2000001021 | Human | Colorectum | AD | 2.92e-17 | -9.32e-01 | 0.0588 |
84898 | PLXDC2 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 1.92e-51 | -1.01e+00 | 0.294 |
84898 | PLXDC2 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 1.47e-12 | -8.28e-01 | 0.281 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PLXDC2 | insertion | Frame_Shift_Ins | novel | c.1342_1343insTTCATTTTGCTTATCAAACTAGAAATTTT | p.Lys448IlefsTer30 | p.K448Ifs*30 | Q6UX71 | protein_coding | TCGA-BH-A0BM-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | ||
PLXDC2 | SNV | Missense_Mutation | novel | c.1115C>A | p.Pro372His | p.P372H | Q6UX71 | protein_coding | tolerated(0.06) | probably_damaging(0.973) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
PLXDC2 | SNV | Missense_Mutation | novel | c.966N>A | p.Met322Ile | p.M322I | Q6UX71 | protein_coding | tolerated(0.2) | benign(0.015) | TCGA-DS-A1OB-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | carboplatin | PD |
PLXDC2 | SNV | Missense_Mutation | c.1229G>T | p.Arg410Ile | p.R410I | Q6UX71 | protein_coding | tolerated(0.16) | possibly_damaging(0.459) | TCGA-HG-A2PA-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unspecific | Taxol | PD | |
PLXDC2 | SNV | Missense_Mutation | rs760841125 | c.1212G>T | p.Arg404Ser | p.R404S | Q6UX71 | protein_coding | tolerated(0.4) | benign(0) | TCGA-AA-3856-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
PLXDC2 | SNV | Missense_Mutation | rs756344797 | c.77N>G | p.Gln26Arg | p.Q26R | Q6UX71 | protein_coding | tolerated_low_confidence(0.78) | benign(0) | TCGA-AA-3973-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Targeted Molecular therapy | bevacizumab | SD |
PLXDC2 | SNV | Missense_Mutation | c.455N>T | p.Thr152Ile | p.T152I | Q6UX71 | protein_coding | deleterious(0) | probably_damaging(0.973) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
PLXDC2 | SNV | Missense_Mutation | c.1138N>C | p.Cys380Arg | p.C380R | Q6UX71 | protein_coding | deleterious(0) | probably_damaging(0.968) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
PLXDC2 | SNV | Missense_Mutation | rs372336202 | c.1082N>A | p.Arg361His | p.R361H | Q6UX71 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-CM-4744-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
PLXDC2 | SNV | Missense_Mutation | c.1435N>T | p.His479Tyr | p.H479Y | Q6UX71 | protein_coding | tolerated(0.49) | benign(0.163) | TCGA-CM-6168-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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