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Gene: PLSCR2 |
Gene summary for PLSCR2 |
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Gene information | Species | Human | Gene symbol | PLSCR2 | Gene ID | 57047 |
Gene name | phospholipid scramblase 2 | |
Gene Alias | PLSCR2 | |
Cytomap | 3q24 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | Q9NRY7 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
57047 | PLSCR2 | CCI_2 | Human | Cervix | CC | 4.20e-06 | 6.61e-01 | 0.5249 |
57047 | PLSCR2 | CCI_3 | Human | Cervix | CC | 3.04e-05 | 6.19e-01 | 0.516 |
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Tissue | Expression Dynamics | Abbreviation |
Cervix | ![]() | CC: Cervix cancer |
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions | ||
N_HPV: HPV-infected normal cervix |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00070092 | Cervix | CC | plasma membrane organization | 28/2311 | 142/18723 | 7.85e-03 | 4.14e-02 | 28 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PLSCR2 | SNV | Missense_Mutation | c.578N>C | p.Tyr193Ser | p.Y193S | Q9NRY7 | protein_coding | deleterious(0.04) | probably_damaging(0.954) | TCGA-AQ-A04H-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | taxotere | SD | |
PLSCR2 | SNV | Missense_Mutation | c.538G>A | p.Glu180Lys | p.E180K | Q9NRY7 | protein_coding | tolerated(0.2) | benign(0.31) | TCGA-C8-A1HM-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | doxorubicin | CR | |
PLSCR2 | SNV | Missense_Mutation | c.599C>T | p.Pro200Leu | p.P200L | Q9NRY7 | protein_coding | tolerated(0.19) | benign(0.106) | TCGA-D8-A27W-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicine+cyclophosphamide | SD | |
PLSCR2 | insertion | Frame_Shift_Ins | novel | c.42_43insAT | p.Pro15IlefsTer37 | p.P15Ifs*37 | Q9NRY7 | protein_coding | TCGA-AC-A3QQ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
PLSCR2 | SNV | Missense_Mutation | c.164N>T | p.Gly55Val | p.G55V | Q9NRY7 | protein_coding | deleterious(0.05) | benign(0.035) | TCGA-AA-3833-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
PLSCR2 | SNV | Missense_Mutation | c.754N>C | p.Ser252Pro | p.S252P | Q9NRY7 | protein_coding | deleterious(0.03) | possibly_damaging(0.713) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
PLSCR2 | SNV | Missense_Mutation | novel | c.289N>A | p.Leu97Ile | p.L97I | Q9NRY7 | protein_coding | tolerated(0.15) | probably_damaging(0.925) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PLSCR2 | SNV | Missense_Mutation | c.772G>A | p.Ala258Thr | p.A258T | Q9NRY7 | protein_coding | tolerated(0.2) | benign(0.26) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
PLSCR2 | SNV | Missense_Mutation | novel | c.203N>A | p.Pro68His | p.P68H | Q9NRY7 | protein_coding | deleterious(0.03) | benign(0.103) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PLSCR2 | SNV | Missense_Mutation | novel | c.75N>T | p.Gln25His | p.Q25H | Q9NRY7 | protein_coding | tolerated(0.15) | benign(0.018) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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