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Gene: PLPBP |
Gene summary for PLPBP |
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Gene information | Species | Human | Gene symbol | PLPBP | Gene ID | 11212 |
Gene name | pyridoxal phosphate binding protein | |
Gene Alias | EPVB6D | |
Cytomap | 8p11.23 | |
Gene Type | protein-coding | GO ID | GO:0008150 | UniProtAcc | O94903 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
11212 | PLPBP | GSM4909308 | Human | Breast | IDC | 5.13e-04 | 2.17e-01 | 0.158 |
11212 | PLPBP | GSM4909317 | Human | Breast | IDC | 6.10e-23 | 5.52e-01 | 0.1355 |
11212 | PLPBP | GSM4909318 | Human | Breast | IDC | 1.06e-07 | 7.18e-01 | 0.2031 |
11212 | PLPBP | GSM4909319 | Human | Breast | IDC | 3.94e-02 | -2.75e-02 | 0.1563 |
11212 | PLPBP | P2 | Human | Breast | IDC | 4.29e-08 | 4.83e-01 | 0.21 |
11212 | PLPBP | DCIS2 | Human | Breast | DCIS | 9.60e-29 | 1.24e-01 | 0.0085 |
11212 | PLPBP | HTA11_78_2000001011 | Human | Colorectum | AD | 9.78e-05 | 3.83e-01 | -0.1088 |
11212 | PLPBP | HTA11_347_2000001011 | Human | Colorectum | AD | 8.49e-18 | 5.37e-01 | -0.1954 |
11212 | PLPBP | HTA11_696_2000001011 | Human | Colorectum | AD | 3.39e-04 | 2.57e-01 | -0.1464 |
11212 | PLPBP | HTA11_5216_2000001011 | Human | Colorectum | SER | 1.01e-02 | 4.94e-01 | -0.1462 |
11212 | PLPBP | HTA11_99999970781_79442 | Human | Colorectum | MSS | 1.71e-02 | -1.14e-01 | 0.294 |
11212 | PLPBP | LZE2T | Human | Esophagus | ESCC | 9.54e-06 | 4.66e-01 | 0.082 |
11212 | PLPBP | LZE4T | Human | Esophagus | ESCC | 1.39e-20 | 5.62e-01 | 0.0811 |
11212 | PLPBP | LZE5T | Human | Esophagus | ESCC | 1.57e-03 | 2.80e-01 | 0.0514 |
11212 | PLPBP | LZE7T | Human | Esophagus | ESCC | 2.56e-05 | 2.13e-01 | 0.0667 |
11212 | PLPBP | LZE8T | Human | Esophagus | ESCC | 9.33e-11 | 3.07e-01 | 0.067 |
11212 | PLPBP | LZE20T | Human | Esophagus | ESCC | 1.97e-04 | 1.53e-01 | 0.0662 |
11212 | PLPBP | LZE22T | Human | Esophagus | ESCC | 2.25e-16 | 6.74e-01 | 0.068 |
11212 | PLPBP | LZE24T | Human | Esophagus | ESCC | 2.33e-28 | 6.74e-01 | 0.0596 |
11212 | PLPBP | LZE6T | Human | Esophagus | ESCC | 5.35e-04 | 1.72e-01 | 0.0845 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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