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Gene: PLLP |
Gene summary for PLLP |
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Gene information | Species | Human | Gene symbol | PLLP | Gene ID | 51090 |
Gene name | plasmolipin | |
Gene Alias | PMLP | |
Cytomap | 16q13 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | A0A024R6T3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
51090 | PLLP | HTA11_2487_2000001011 | Human | Colorectum | SER | 6.85e-08 | 4.26e-01 | -0.1808 |
51090 | PLLP | HTA11_347_2000001011 | Human | Colorectum | AD | 2.49e-05 | 2.43e-01 | -0.1954 |
51090 | PLLP | HTA11_411_2000001011 | Human | Colorectum | SER | 5.55e-06 | 8.09e-01 | -0.2602 |
51090 | PLLP | HTA11_2112_2000001011 | Human | Colorectum | SER | 6.94e-08 | 8.38e-01 | -0.2196 |
51090 | PLLP | HTA11_696_2000001011 | Human | Colorectum | AD | 7.23e-07 | 3.21e-01 | -0.1464 |
51090 | PLLP | HTA11_1391_2000001011 | Human | Colorectum | AD | 6.31e-03 | 2.30e-01 | -0.059 |
51090 | PLLP | HTA11_2992_2000001011 | Human | Colorectum | SER | 5.88e-04 | 4.82e-01 | -0.1706 |
51090 | PLLP | HTA11_5212_2000001011 | Human | Colorectum | AD | 3.86e-03 | 3.58e-01 | -0.2061 |
51090 | PLLP | LZE4T | Human | Esophagus | ESCC | 8.22e-05 | 1.72e-01 | 0.0811 |
51090 | PLLP | LZE20T | Human | Esophagus | ESCC | 2.93e-07 | 2.13e-01 | 0.0662 |
51090 | PLLP | LZE24T | Human | Esophagus | ESCC | 2.11e-07 | 2.82e-01 | 0.0596 |
51090 | PLLP | LZE21T | Human | Esophagus | ESCC | 4.13e-02 | 3.70e-01 | 0.0655 |
51090 | PLLP | P1T-E | Human | Esophagus | ESCC | 4.70e-07 | 5.77e-01 | 0.0875 |
51090 | PLLP | P2T-E | Human | Esophagus | ESCC | 1.23e-11 | 2.61e-01 | 0.1177 |
51090 | PLLP | P4T-E | Human | Esophagus | ESCC | 2.29e-17 | 4.81e-01 | 0.1323 |
51090 | PLLP | P8T-E | Human | Esophagus | ESCC | 1.09e-53 | 1.24e+00 | 0.0889 |
51090 | PLLP | P12T-E | Human | Esophagus | ESCC | 8.84e-14 | 3.46e-01 | 0.1122 |
51090 | PLLP | P15T-E | Human | Esophagus | ESCC | 7.55e-23 | 6.11e-01 | 0.1149 |
51090 | PLLP | P20T-E | Human | Esophagus | ESCC | 1.54e-05 | 2.84e-01 | 0.1124 |
51090 | PLLP | P21T-E | Human | Esophagus | ESCC | 5.46e-28 | 8.51e-01 | 0.1617 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00425524 | Esophagus | ESCC | myelination | 85/8552 | 134/18723 | 2.51e-05 | 2.13e-04 | 85 |
GO:00072724 | Esophagus | ESCC | ensheathment of neurons | 86/8552 | 136/18723 | 2.68e-05 | 2.24e-04 | 86 |
GO:00083664 | Esophagus | ESCC | axon ensheathment | 86/8552 | 136/18723 | 2.68e-05 | 2.24e-04 | 86 |
GO:0042552 | Liver | Cirrhotic | myelination | 46/4634 | 134/18723 | 8.04e-03 | 3.77e-02 | 46 |
GO:0007272 | Liver | Cirrhotic | ensheathment of neurons | 46/4634 | 136/18723 | 1.08e-02 | 4.75e-02 | 46 |
GO:0008366 | Liver | Cirrhotic | axon ensheathment | 46/4634 | 136/18723 | 1.08e-02 | 4.75e-02 | 46 |
GO:00072721 | Liver | HCC | ensheathment of neurons | 72/7958 | 136/18723 | 8.87e-03 | 3.44e-02 | 72 |
GO:00083661 | Liver | HCC | axon ensheathment | 72/7958 | 136/18723 | 8.87e-03 | 3.44e-02 | 72 |
GO:00425521 | Liver | HCC | myelination | 71/7958 | 134/18723 | 9.08e-03 | 3.49e-02 | 71 |
GO:00072723 | Oral cavity | OSCC | ensheathment of neurons | 72/7305 | 136/18723 | 6.59e-04 | 3.70e-03 | 72 |
GO:00083663 | Oral cavity | OSCC | axon ensheathment | 72/7305 | 136/18723 | 6.59e-04 | 3.70e-03 | 72 |
GO:00425523 | Oral cavity | OSCC | myelination | 71/7305 | 134/18723 | 6.93e-04 | 3.86e-03 | 71 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PLLP | SNV | Missense_Mutation | rs373265334 | c.457G>A | p.Ala153Thr | p.A153T | Q9Y342 | protein_coding | tolerated(0.19) | benign(0.041) | TCGA-AP-A051-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PLLP | SNV | Missense_Mutation | rs747990637 | c.331N>A | p.Ala111Thr | p.A111T | Q9Y342 | protein_coding | deleterious(0) | probably_damaging(0.966) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
PLLP | SNV | Missense_Mutation | rs367720602 | c.337N>A | p.Val113Ile | p.V113I | Q9Y342 | protein_coding | tolerated(0.2) | benign(0.066) | TCGA-DF-A2KU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
PLLP | SNV | Missense_Mutation | novel | c.214N>T | p.Val72Phe | p.V72F | Q9Y342 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-43-8116-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
PLLP | SNV | Missense_Mutation | rs754274845 | c.431N>T | p.Ser144Leu | p.S144L | Q9Y342 | protein_coding | deleterious(0) | probably_damaging(0.958) | TCGA-94-8491-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | unknown | PD |
PLLP | SNV | Missense_Mutation | rs776743553 | c.497N>A | p.Arg166Gln | p.R166Q | Q9Y342 | protein_coding | tolerated(0.07) | benign(0.26) | TCGA-2A-A8W1-01 | Prostate | prostate adenocarcinoma | Male | <65 | 7 | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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