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Gene: PLEKHH1 |
Gene summary for PLEKHH1 |
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Gene information | Species | Human | Gene symbol | PLEKHH1 | Gene ID | 57475 |
Gene name | pleckstrin homology, MyTH4 and FERM domain containing H1 | |
Gene Alias | PLEKHH1 | |
Cytomap | 14q24.1 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q9ULM0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
57475 | PLEKHH1 | Adj_PTCwithHT_6 | Human | Thyroid | HT | 1.21e-04 | -2.47e-01 | 0.02 |
57475 | PLEKHH1 | PTCwithHT_6 | Human | Thyroid | HT | 3.99e-02 | -2.45e-01 | 0.02 |
57475 | PLEKHH1 | PTCwithHT_8 | Human | Thyroid | HT | 2.56e-04 | -2.34e-01 | 0.0351 |
57475 | PLEKHH1 | PTCwithoutHT_2 | Human | Thyroid | PTC | 9.60e-03 | -2.33e-01 | 0.0419 |
57475 | PLEKHH1 | male-WTA | Human | Thyroid | PTC | 2.11e-29 | 1.78e-01 | 0.1037 |
57475 | PLEKHH1 | PTC01 | Human | Thyroid | PTC | 4.18e-08 | -3.01e-02 | 0.1899 |
57475 | PLEKHH1 | PTC03 | Human | Thyroid | PTC | 5.00e-09 | 2.99e-01 | 0.1784 |
57475 | PLEKHH1 | PTC04 | Human | Thyroid | PTC | 2.41e-19 | 2.18e-01 | 0.1927 |
57475 | PLEKHH1 | PTC05 | Human | Thyroid | PTC | 1.01e-12 | 4.51e-01 | 0.2065 |
57475 | PLEKHH1 | PTC06 | Human | Thyroid | PTC | 2.50e-27 | 6.79e-01 | 0.2057 |
57475 | PLEKHH1 | PTC07 | Human | Thyroid | PTC | 1.39e-33 | 4.37e-01 | 0.2044 |
57475 | PLEKHH1 | ATC12 | Human | Thyroid | ATC | 4.26e-04 | -2.42e-01 | 0.34 |
57475 | PLEKHH1 | ATC13 | Human | Thyroid | ATC | 7.21e-04 | -2.39e-01 | 0.34 |
57475 | PLEKHH1 | ATC4 | Human | Thyroid | ATC | 9.68e-04 | -2.41e-01 | 0.34 |
57475 | PLEKHH1 | ATC5 | Human | Thyroid | ATC | 1.72e-03 | -2.38e-01 | 0.34 |
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Tissue | Expression Dynamics | Abbreviation |
Thyroid | ![]() | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis | ||
PTC: Papillary thyroid cancer |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PLEKHH1 | SNV | Missense_Mutation | c.952N>A | p.Pro318Thr | p.P318T | Q9ULM0 | protein_coding | deleterious(0.01) | possibly_damaging(0.721) | TCGA-A1-A0SI-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
PLEKHH1 | SNV | Missense_Mutation | novel | c.4019N>T | p.Cys1340Phe | p.C1340F | Q9ULM0 | protein_coding | tolerated_low_confidence(0.68) | benign(0.001) | TCGA-A2-A25A-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Cytoxan | SD |
PLEKHH1 | SNV | Missense_Mutation | c.2142C>G | p.Phe714Leu | p.F714L | Q9ULM0 | protein_coding | tolerated(0.7) | benign(0.029) | TCGA-D8-A1JG-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | |
PLEKHH1 | SNV | Missense_Mutation | c.2150N>C | p.Tyr717Ser | p.Y717S | Q9ULM0 | protein_coding | deleterious(0.02) | benign(0.306) | TCGA-E2-A1LA-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | arimidex | SD | |
PLEKHH1 | SNV | Missense_Mutation | c.779G>A | p.Gly260Glu | p.G260E | Q9ULM0 | protein_coding | tolerated_low_confidence(0.51) | benign(0) | TCGA-GM-A2D9-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD | |
PLEKHH1 | insertion | In_Frame_Ins | novel | c.3677_3678insCCCTTCTCTCCT | p.Gly1226_Ala1227insProSerLeuLeu | p.G1226_A1227insPSLL | Q9ULM0 | protein_coding | TCGA-A2-A0CT-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | cytoxan | SD | ||
PLEKHH1 | insertion | Frame_Shift_Ins | novel | c.3625_3626insTG | p.Pro1209LeufsTer9 | p.P1209Lfs*9 | Q9ULM0 | protein_coding | TCGA-A8-A08H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
PLEKHH1 | insertion | Frame_Shift_Ins | novel | c.3626_3627insCAGCCTCCACAGGGTTGTACTAAGTA | p.Glu1210SerfsTer16 | p.E1210Sfs*16 | Q9ULM0 | protein_coding | TCGA-A8-A08H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
PLEKHH1 | insertion | In_Frame_Ins | novel | c.179_180insTTGGGCCACTTGGTGTAATATCCAGAATTTCCA | p.Ala60_Glu61insTrpAlaThrTrpCysAsnIleGlnAsnPheHis | p.A60_E61insWATWCNIQNFH | Q9ULM0 | protein_coding | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
PLEKHH1 | insertion | Frame_Shift_Ins | novel | c.3498_3499insAGGCTGTA | p.Leu1167ArgfsTer9 | p.L1167Rfs*9 | Q9ULM0 | protein_coding | TCGA-BH-A0B1-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | adriamycin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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