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Gene: PLEKHG6 |
Gene summary for PLEKHG6 |
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Gene information | Species | Human | Gene symbol | PLEKHG6 | Gene ID | 55200 |
Gene name | pleckstrin homology and RhoGEF domain containing G6 | |
Gene Alias | MyoGEF | |
Cytomap | 12p13.31 | |
Gene Type | protein-coding | GO ID | GO:0007154 | UniProtAcc | Q3KR16 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55200 | PLEKHG6 | LZE20T | Human | Esophagus | ESCC | 3.05e-02 | 1.24e-01 | 0.0662 |
55200 | PLEKHG6 | LZE24T | Human | Esophagus | ESCC | 3.55e-02 | 9.19e-02 | 0.0596 |
55200 | PLEKHG6 | P1T-E | Human | Esophagus | ESCC | 2.36e-08 | 4.02e-01 | 0.0875 |
55200 | PLEKHG6 | P2T-E | Human | Esophagus | ESCC | 7.07e-38 | 6.75e-01 | 0.1177 |
55200 | PLEKHG6 | P4T-E | Human | Esophagus | ESCC | 3.25e-12 | 3.05e-01 | 0.1323 |
55200 | PLEKHG6 | P5T-E | Human | Esophagus | ESCC | 7.07e-12 | 2.44e-01 | 0.1327 |
55200 | PLEKHG6 | P8T-E | Human | Esophagus | ESCC | 2.40e-09 | 2.07e-01 | 0.0889 |
55200 | PLEKHG6 | P9T-E | Human | Esophagus | ESCC | 2.61e-04 | 1.20e-01 | 0.1131 |
55200 | PLEKHG6 | P11T-E | Human | Esophagus | ESCC | 4.90e-02 | 1.64e-01 | 0.1426 |
55200 | PLEKHG6 | P12T-E | Human | Esophagus | ESCC | 3.57e-17 | 3.34e-01 | 0.1122 |
55200 | PLEKHG6 | P15T-E | Human | Esophagus | ESCC | 9.41e-07 | 2.07e-01 | 0.1149 |
55200 | PLEKHG6 | P16T-E | Human | Esophagus | ESCC | 1.08e-08 | 8.97e-02 | 0.1153 |
55200 | PLEKHG6 | P22T-E | Human | Esophagus | ESCC | 1.46e-03 | 9.88e-02 | 0.1236 |
55200 | PLEKHG6 | P23T-E | Human | Esophagus | ESCC | 1.70e-09 | 2.61e-01 | 0.108 |
55200 | PLEKHG6 | P24T-E | Human | Esophagus | ESCC | 4.01e-03 | 1.59e-01 | 0.1287 |
55200 | PLEKHG6 | P26T-E | Human | Esophagus | ESCC | 8.59e-05 | 1.45e-01 | 0.1276 |
55200 | PLEKHG6 | P27T-E | Human | Esophagus | ESCC | 8.51e-11 | 2.44e-01 | 0.1055 |
55200 | PLEKHG6 | P28T-E | Human | Esophagus | ESCC | 5.38e-15 | 2.98e-01 | 0.1149 |
55200 | PLEKHG6 | P30T-E | Human | Esophagus | ESCC | 3.29e-06 | 2.65e-01 | 0.137 |
55200 | PLEKHG6 | P31T-E | Human | Esophagus | ESCC | 9.85e-10 | 1.46e-01 | 0.1251 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:005105610 | Esophagus | ESCC | regulation of small GTPase mediated signal transduction | 157/8552 | 302/18723 | 1.55e-02 | 4.98e-02 | 157 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PLEKHG6 | SNV | Missense_Mutation | c.2300N>C | p.Arg767Pro | p.R767P | Q3KR16 | protein_coding | deleterious_low_confidence(0.01) | benign(0.204) | TCGA-A2-A04T-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | SD | |
PLEKHG6 | SNV | Missense_Mutation | c.1729N>A | p.Asp577Asn | p.D577N | Q3KR16 | protein_coding | deleterious(0.01) | probably_damaging(0.994) | TCGA-A8-A094-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
PLEKHG6 | SNV | Missense_Mutation | rs761204546 | c.1853N>A | p.Arg618His | p.R618H | Q3KR16 | protein_coding | deleterious_low_confidence(0) | possibly_damaging(0.765) | TCGA-AC-A8OP-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PLEKHG6 | SNV | Missense_Mutation | rs147609266 | c.1187N>T | p.Thr396Met | p.T396M | Q3KR16 | protein_coding | tolerated(0.52) | benign(0.006) | TCGA-LD-A7W6-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | letrozole | SD |
PLEKHG6 | insertion | Frame_Shift_Ins | novel | c.1615_1616insAATATCTGGTTCATGGG | p.Ser539LysfsTer38 | p.S539Kfs*38 | Q3KR16 | protein_coding | TCGA-A8-A092-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | CR | ||
PLEKHG6 | SNV | Missense_Mutation | c.243G>C | p.Lys81Asn | p.K81N | Q3KR16 | protein_coding | deleterious(0.04) | benign(0.31) | TCGA-C5-A7CO-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | cisplatin | SD | |
PLEKHG6 | SNV | Missense_Mutation | novel | c.650G>A | p.Arg217Gln | p.R217Q | Q3KR16 | protein_coding | tolerated(0.15) | probably_damaging(0.973) | TCGA-EA-A3HU-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
PLEKHG6 | deletion | Frame_Shift_Del | novel | c.1907_1910delNNNN | p.Asp637ProfsTer17 | p.D637Pfs*17 | Q3KR16 | protein_coding | TCGA-DS-A1OA-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | carboplatin | PD | ||
PLEKHG6 | SNV | Missense_Mutation | c.463A>G | p.Met155Val | p.M155V | Q3KR16 | protein_coding | deleterious(0.01) | probably_damaging(0.914) | TCGA-A6-5667-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | oxaliplatin | SD | |
PLEKHG6 | SNV | Missense_Mutation | rs370357030 | c.424N>A | p.Glu142Lys | p.E142K | Q3KR16 | protein_coding | deleterious(0) | probably_damaging(0.986) | TCGA-AA-3877-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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