Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

Home

Download

Statistics

Help

Contact

Center for Computational Systems Medicine
leaf

Gene summary

leaf

Malignant transformation analysis

leaf

Malignant transformation related pathway analysis

leaf

Cell-cell communication analysis

leaf

Single-cell gene regulatory network inference analysis

leaf

Somatic mutation of malignant transformation related genes

leaf

Related drugs of malignant transformation related genes

Gene: PLEK2

Gene summary for PLEK2

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

PLEK2

Gene ID

26499

Gene namepleckstrin 2
Gene AliasPLEK2
Cytomap14q23.3-q24.1
Gene Typeprotein-coding
GO ID

GO:0006996

UniProtAcc

Q9NYT0


Top

Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
26499PLEK2HTA11_1938_2000001011HumanColorectumAD8.80e-105.86e-01-0.0811
26499PLEK2HTA11_78_2000001011HumanColorectumAD1.75e-053.93e-01-0.1088
26499PLEK2HTA11_83_2000001011HumanColorectumSER4.69e-086.48e-01-0.1526
26499PLEK2HTA11_696_2000001011HumanColorectumAD4.53e-022.42e-01-0.1464
26499PLEK2HTA11_1391_2000001011HumanColorectumAD5.83e-116.19e-01-0.059
26499PLEK2HTA11_866_3004761011HumanColorectumAD4.22e-043.34e-010.096
26499PLEK2HTA11_7696_3000711011HumanColorectumAD9.24e-062.97e-010.0674
26499PLEK2HTA11_6818_2000001021HumanColorectumAD1.59e-034.24e-010.0588
26499PLEK2HTA11_99999970781_79442HumanColorectumMSS1.28e-154.63e-010.294
26499PLEK2HTA11_99999971662_82457HumanColorectumMSS2.71e-042.83e-010.3859
26499PLEK2HTA11_99999974143_84620HumanColorectumMSS4.81e-032.10e-010.3005
26499PLEK2LZE7THumanEsophagusESCC1.85e-038.68e-020.0667
26499PLEK2LZE6THumanEsophagusESCC1.27e-035.59e-010.0845
26499PLEK2P2T-EHumanEsophagusESCC3.10e-338.99e-010.1177
26499PLEK2P4T-EHumanEsophagusESCC1.51e-311.01e+000.1323
26499PLEK2P5T-EHumanEsophagusESCC1.49e-075.04e-010.1327
26499PLEK2P8T-EHumanEsophagusESCC5.32e-122.09e-010.0889
26499PLEK2P10T-EHumanEsophagusESCC4.24e-062.74e-010.116
26499PLEK2P11T-EHumanEsophagusESCC5.86e-119.94e-010.1426
26499PLEK2P15T-EHumanEsophagusESCC4.79e-136.73e-010.1149
Page: 1 2 3 4 5 

check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
Colorectum (GSE201348)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.FAP: Familial adenomatous polyposis
CRC: Colorectal cancer
Colorectum (HTA11)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AD: Adenomas
SER: Sessile serrated lesions
MSI-H: Microsatellite-high colorectal cancer
MSS: Microsatellite stable colorectal cancer
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
SkinThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AK: Actinic keratosis
cSCC: Cutaneous squamous cell carcinoma
SCCIS:squamous cell carcinoma in situ
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

Top

Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
Page: 1 2 3 4 5 6 7 8 9 

check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:0031532ColorectumADactin cytoskeleton reorganization41/3918107/187232.81e-055.28e-0441
GO:0031346ColorectumADpositive regulation of cell projection organization104/3918353/187238.26e-051.30e-03104
GO:0120034ColorectumADpositive regulation of plasma membrane bounded cell projection assembly33/3918105/187237.49e-034.55e-0233
GO:0120032ColorectumADregulation of plasma membrane bounded cell projection assembly53/3918186/187238.51e-034.97e-0253
GO:00315321ColorectumSERactin cytoskeleton reorganization30/2897107/187236.38e-048.64e-0330
GO:00313461ColorectumSERpositive regulation of cell projection organization75/2897353/187232.22e-032.14e-0275
GO:01200321ColorectumSERregulation of plasma membrane bounded cell projection assembly43/2897186/187233.82e-033.16e-0243
GO:0060491ColorectumSERregulation of cell projection assembly43/2897188/187234.68e-033.70e-0243
GO:00315322ColorectumMSSactin cytoskeleton reorganization41/3467107/187231.21e-064.06e-0541
GO:00313462ColorectumMSSpositive regulation of cell projection organization96/3467353/187233.44e-056.70e-0496
GO:01200322ColorectumMSSregulation of plasma membrane bounded cell projection assembly51/3467186/187231.78e-031.58e-0251
GO:00604911ColorectumMSSregulation of cell projection assembly51/3467188/187232.28e-031.87e-0251
GO:01200341ColorectumMSSpositive regulation of plasma membrane bounded cell projection assembly30/3467105/187237.74e-034.84e-0230
GO:003153218EsophagusESCCactin cytoskeleton reorganization72/8552107/187235.03e-065.31e-0572
GO:003134616EsophagusESCCpositive regulation of cell projection organization201/8552353/187231.19e-051.11e-04201
GO:006049118EsophagusESCCregulation of cell projection assembly110/8552188/187232.60e-041.58e-03110
GO:012003218EsophagusESCCregulation of plasma membrane bounded cell projection assembly108/8552186/187234.37e-042.46e-03108
GO:01200347EsophagusESCCpositive regulation of plasma membrane bounded cell projection assembly64/8552105/187231.15e-035.70e-0364
GO:003153216Oral cavityOSCCactin cytoskeleton reorganization65/7305107/187234.25e-064.93e-0565
GO:003134610Oral cavityOSCCpositive regulation of cell projection organization176/7305353/187231.94e-051.87e-04176
Page: 1 2 

check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
Page: 1 

Top

Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
Page: 1 

Top

Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
Page: 1 

Top

Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
PLEK2SNVMissense_Mutationc.75G>Tp.Trp25Cysp.W25CQ9NYT0protein_codingdeleterious(0)probably_damaging(0.999)TCGA-D8-A1JD-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapyadriamycinSD
PLEK2SNVMissense_Mutationrs146989539c.925G>Ap.Val309Ilep.V309IQ9NYT0protein_codingtolerated(0.1)benign(0.317)TCGA-AA-3492-01Colorectumcolon adenocarcinomaFemale>=65I/IIUnknownUnknownSD
PLEK2SNVMissense_Mutationc.509C>Tp.Ser170Phep.S170FQ9NYT0protein_codingtolerated(0.2)benign(0.085)TCGA-AZ-5407-01Colorectumcolon adenocarcinomaFemale<65I/IIUnknownUnknownSD
PLEK2SNVMissense_Mutationnovelc.689A>Gp.Lys230Argp.K230RQ9NYT0protein_codingtolerated(0.64)benign(0)TCGA-CA-6717-01Colorectumcolon adenocarcinomaMale<65I/IIChemotherapyoxaliplatinCR
PLEK2SNVMissense_Mutationc.917N>Tp.Asp306Valp.D306VQ9NYT0protein_codingdeleterious(0)probably_damaging(0.999)TCGA-CK-4951-01Colorectumcolon adenocarcinomaFemale>=65I/IIUnknownUnknownPD
PLEK2SNVMissense_Mutationnovelc.655G>Ap.Ala219Thrp.A219TQ9NYT0protein_codingdeleterious(0)probably_damaging(0.998)TCGA-A5-A0G2-01Endometriumuterine corpus endometrioid carcinomaFemale<65III/IVUnknownUnknownSD
PLEK2SNVMissense_Mutationnovelc.353G>Tp.Arg118Ilep.R118IQ9NYT0protein_codingdeleterious(0)benign(0.012)TCGA-A5-A2K5-01Endometriumuterine corpus endometrioid carcinomaFemale>=65I/IIUnknownUnknownSD
PLEK2SNVMissense_Mutationnovelc.1031N>Cp.Glu344Alap.E344AQ9NYT0protein_codingtolerated(0.07)benign(0.246)TCGA-AJ-A3EK-01Endometriumuterine corpus endometrioid carcinomaFemale<65I/IIChemotherapycarboplatinCR
PLEK2SNVMissense_Mutationnovelc.977N>Ap.Thr326Asnp.T326NQ9NYT0protein_codingdeleterious(0)probably_damaging(0.999)TCGA-AP-A059-01Endometriumuterine corpus endometrioid carcinomaFemale>=65I/IIUnknownUnknownSD
PLEK2SNVMissense_Mutationrs373046007c.301N>Ap.Gly101Argp.G101RQ9NYT0protein_codingtolerated(0.66)probably_damaging(0.944)TCGA-AP-A0LM-01Endometriumuterine corpus endometrioid carcinomaFemale<65III/IVChemotherapycisplatinSD
Page: 1 2 3 4 

Top

Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
Page: 1