Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: PLCB3

Gene summary for PLCB3

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

PLCB3

Gene ID

5331

Gene namephospholipase C beta 3
Gene AliasSMDCD
Cytomap11q13.1
Gene Typeprotein-coding
GO ID

GO:0003008

UniProtAcc

Q01970


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
5331PLCB3HTA11_2487_2000001011HumanColorectumSER2.39e-095.66e-01-0.1808
5331PLCB3HTA11_1938_2000001011HumanColorectumAD1.21e-065.28e-01-0.0811
5331PLCB3HTA11_347_2000001011HumanColorectumAD1.50e-073.27e-01-0.1954
5331PLCB3HTA11_696_2000001011HumanColorectumAD2.16e-043.31e-01-0.1464
5331PLCB3HTA11_1391_2000001011HumanColorectumAD2.38e-074.81e-01-0.059
5331PLCB3HTA11_8622_2000001021HumanColorectumSER2.77e-022.59e-010.0528
5331PLCB3HTA11_10711_2000001011HumanColorectumAD3.16e-022.32e-010.0338
5331PLCB3HTA11_7696_3000711011HumanColorectumAD8.94e-052.95e-010.0674
5331PLCB3HTA11_99999971662_82457HumanColorectumMSS1.27e-114.18e-010.3859
5331PLCB3HTA11_99999973899_84307HumanColorectumMSS1.27e-044.53e-010.2585
5331PLCB3LZE2THumanEsophagusESCC2.44e-023.90e-010.082
5331PLCB3LZE24THumanEsophagusESCC3.71e-112.98e-010.0596
5331PLCB3P1T-EHumanEsophagusESCC5.15e-073.05e-010.0875
5331PLCB3P2T-EHumanEsophagusESCC9.16e-081.43e-010.1177
5331PLCB3P4T-EHumanEsophagusESCC1.42e-061.51e-010.1323
5331PLCB3P5T-EHumanEsophagusESCC1.08e-102.09e-010.1327
5331PLCB3P8T-EHumanEsophagusESCC1.28e-046.23e-020.0889
5331PLCB3P9T-EHumanEsophagusESCC2.19e-039.63e-020.1131
5331PLCB3P10T-EHumanEsophagusESCC4.83e-095.98e-020.116
5331PLCB3P11T-EHumanEsophagusESCC2.86e-063.50e-010.1426
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
Colorectum (GSE201348)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.FAP: Familial adenomatous polyposis
CRC: Colorectal cancer
Colorectum (HTA11)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AD: Adenomas
SER: Sessile serrated lesions
MSI-H: Microsatellite-high colorectal cancer
MSS: Microsatellite stable colorectal cancer
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
SkinThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AK: Actinic keratosis
cSCC: Cutaneous squamous cell carcinoma
SCCIS:squamous cell carcinoma in situ
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:0016042ColorectumADlipid catabolic process97/3918320/187234.31e-057.56e-0497
GO:0048017ColorectumADinositol lipid-mediated signaling53/3918182/187235.35e-033.52e-0253
GO:0048015ColorectumADphosphatidylinositol-mediated signaling52/3918178/187235.37e-033.54e-0252
GO:0006650ColorectumADglycerophospholipid metabolic process83/3918306/187235.40e-033.55e-0283
GO:0006644ColorectumADphospholipid metabolic process101/3918383/187235.80e-033.67e-02101
GO:00160421ColorectumSERlipid catabolic process77/2897320/187233.52e-059.18e-0477
GO:0046486ColorectumSERglycerolipid metabolic process82/2897392/187232.26e-032.17e-0282
GO:00066441ColorectumSERphospholipid metabolic process79/2897383/187233.94e-033.24e-0279
GO:00480171ColorectumSERinositol lipid-mediated signaling42/2897182/187234.36e-033.49e-0242
GO:00480151ColorectumSERphosphatidylinositol-mediated signaling41/2897178/187234.97e-033.86e-0241
GO:00066501ColorectumSERglycerophospholipid metabolic process64/2897306/187236.41e-034.60e-0264
GO:00160422ColorectumMSSlipid catabolic process77/3467320/187237.43e-034.71e-0277
GO:00066446EsophagusESCCphospholipid metabolic process218/8552383/187235.37e-065.59e-05218
GO:00066505EsophagusESCCglycerophospholipid metabolic process174/8552306/187234.92e-053.85e-04174
GO:00464864EsophagusESCCglycerolipid metabolic process211/8552392/187236.51e-043.46e-03211
GO:00160427EsophagusESCClipid catabolic process168/8552320/187237.97e-032.84e-02168
GO:00066445Oral cavityOSCCphospholipid metabolic process175/7305383/187234.21e-031.71e-02175
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
hsa05415ColorectumADDiabetic cardiomyopathy114/2092203/84653.65e-223.06e-201.95e-20114
hsa05010ColorectumADAlzheimer disease174/2092384/84651.82e-199.26e-185.91e-18174
hsa05016ColorectumADHuntington disease147/2092306/84651.93e-199.26e-185.91e-18147
hsa05022ColorectumADPathways of neurodegeneration - multiple diseases201/2092476/84654.54e-181.27e-168.09e-17201
hsa05131ColorectumADShigellosis109/2092247/84651.09e-112.44e-101.55e-10109
hsa05017ColorectumADSpinocerebellar ataxia60/2092143/84653.78e-064.35e-052.78e-0560
hsa04919ColorectumADThyroid hormone signaling pathway51/2092121/84651.71e-051.73e-041.10e-0451
hsa04723ColorectumADRetrograde endocannabinoid signaling59/2092148/84652.94e-052.73e-041.74e-0459
hsa04961ColorectumADEndocrine and other factor-regulated calcium reabsorption24/209253/84658.49e-045.93e-033.78e-0324
hsa04922ColorectumADGlucagon signaling pathway41/2092107/84651.18e-037.75e-034.94e-0341
hsa05417ColorectumADLipid and atherosclerosis73/2092215/84651.31e-038.27e-035.27e-0373
hsa04015ColorectumADRap1 signaling pathway71/2092210/84651.72e-039.68e-036.18e-0371
hsa05163ColorectumADHuman cytomegalovirus infection75/2092225/84652.00e-031.10e-027.01e-0375
hsa04912ColorectumADGnRH signaling pathway35/209293/84653.69e-031.90e-021.21e-0235
hsa04071ColorectumADSphingolipid signaling pathway43/2092121/84654.83e-032.28e-021.45e-0243
hsa04728ColorectumADDopaminergic synapse46/2092132/84655.55e-032.48e-021.58e-0246
hsa04971ColorectumADGastric acid secretion29/209276/84656.25e-032.68e-021.71e-0229
hsa04928ColorectumADParathyroid hormone synthesis, secretion and action38/2092106/84656.60e-032.77e-021.76e-0238
hsa04720ColorectumADLong-term potentiation26/209267/84657.26e-032.97e-021.89e-0226
hsa04310ColorectumADWnt signaling pathway56/2092171/84651.03e-023.93e-022.51e-0256
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
PLCB3SNVMissense_Mutationnovelc.616N>Cp.Asp206Hisp.D206HQ01970protein_codingdeleterious(0)probably_damaging(0.958)TCGA-5L-AAT1-01Breastbreast invasive carcinomaFemale<65III/IVHormone TherapyletrozolSD
PLCB3SNVMissense_Mutationnovelc.1337N>Ap.Pro446Glnp.P446QQ01970protein_codingdeleterious(0.02)probably_damaging(0.967)TCGA-A7-A6VY-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapycyclophosphamideCR
PLCB3SNVMissense_Mutationrs371998747c.227N>Ap.Arg76Glnp.R76QQ01970protein_codingdeleterious(0)possibly_damaging(0.465)TCGA-BH-A0BT-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapyadriamycinCR
PLCB3SNVMissense_Mutationc.2269G>Ap.Asp757Asnp.D757NQ01970protein_codingdeleterious(0)probably_damaging(1)TCGA-D8-A27R-01Breastbreast invasive carcinomaFemale<65III/IVChemotherapyadriamycin+cyclophosphamideSD
PLCB3insertionNonsense_Mutationnovelc.1850_1851insATGTCTATAATTTACTCCCAAATGATTCAGTAAAAp.Met617IlefsTer4p.M617Ifs*4Q01970protein_codingTCGA-A8-A09K-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
PLCB3SNVMissense_Mutationnovelc.2294G>Ap.Arg765Glnp.R765QQ01970protein_codingdeleterious(0)benign(0.103)TCGA-EA-A410-01Cervixcervical & endocervical cancerFemale<65I/IIUnknownUnknownSD
PLCB3SNVMissense_Mutationnovelc.3081G>Tp.Glu1027Aspp.E1027DQ01970protein_codingtolerated(0.58)benign(0.18)TCGA-EA-A410-01Cervixcervical & endocervical cancerFemale<65I/IIUnknownUnknownSD
PLCB3SNVMissense_Mutationrs776004312c.3542C>Tp.Ala1181Valp.A1181VQ01970protein_codingtolerated(0.08)benign(0.052)TCGA-VS-A9UV-01Cervixcervical & endocervical cancerFemale>=65I/IIUnknownUnknownPD
PLCB3SNVMissense_Mutationnovelc.1006C>Gp.Leu336Valp.L336VQ01970protein_codingdeleterious(0)probably_damaging(0.982)TCGA-ZJ-AAXU-01Cervixcervical & endocervical cancerFemale<65I/IIUnknownUnknownSD
PLCB3SNVMissense_Mutationnovelc.803N>Ap.Arg268Glnp.R268QQ01970protein_codingdeleterious(0.05)benign(0.277)TCGA-5M-AAT6-01Colorectumcolon adenocarcinomaFemale<65III/IVUnknownUnknownPD
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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