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Gene: PLBD1 |
Gene summary for PLBD1 |
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Gene information | Species | Human | Gene symbol | PLBD1 | Gene ID | 79887 |
Gene name | phospholipase B domain containing 1 | |
Gene Alias | PLBD1 | |
Cytomap | 12p13.1 | |
Gene Type | protein-coding | GO ID | GO:0006629 | UniProtAcc | Q6P4A8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
79887 | PLBD1 | Tumor | Human | Cervix | CC | 1.87e-21 | 5.00e-01 | 0.1241 |
79887 | PLBD1 | sample3 | Human | Cervix | CC | 3.27e-34 | 5.86e-01 | 0.1387 |
79887 | PLBD1 | T3 | Human | Cervix | CC | 7.06e-30 | 6.35e-01 | 0.1389 |
79887 | PLBD1 | LZE2T | Human | Esophagus | ESCC | 3.15e-03 | 4.94e-01 | 0.082 |
79887 | PLBD1 | LZE20T | Human | Esophagus | ESCC | 1.30e-12 | 5.58e-01 | 0.0662 |
79887 | PLBD1 | LZE22D1 | Human | Esophagus | HGIN | 1.92e-07 | 3.42e-01 | 0.0595 |
79887 | PLBD1 | LZE22T | Human | Esophagus | ESCC | 7.02e-13 | 9.15e-01 | 0.068 |
79887 | PLBD1 | LZE24T | Human | Esophagus | ESCC | 2.88e-28 | 6.83e-01 | 0.0596 |
79887 | PLBD1 | P1T-E | Human | Esophagus | ESCC | 3.93e-04 | 3.95e-01 | 0.0875 |
79887 | PLBD1 | P2T-E | Human | Esophagus | ESCC | 1.10e-26 | 6.21e-01 | 0.1177 |
79887 | PLBD1 | P4T-E | Human | Esophagus | ESCC | 2.88e-62 | 1.45e+00 | 0.1323 |
79887 | PLBD1 | P5T-E | Human | Esophagus | ESCC | 6.47e-24 | 5.70e-01 | 0.1327 |
79887 | PLBD1 | P8T-E | Human | Esophagus | ESCC | 5.75e-22 | 6.02e-01 | 0.0889 |
79887 | PLBD1 | P9T-E | Human | Esophagus | ESCC | 1.54e-29 | 7.06e-01 | 0.1131 |
79887 | PLBD1 | P10T-E | Human | Esophagus | ESCC | 7.03e-09 | 1.67e-01 | 0.116 |
79887 | PLBD1 | P11T-E | Human | Esophagus | ESCC | 8.56e-17 | 6.79e-01 | 0.1426 |
79887 | PLBD1 | P12T-E | Human | Esophagus | ESCC | 2.72e-50 | 1.10e+00 | 0.1122 |
79887 | PLBD1 | P15T-E | Human | Esophagus | ESCC | 2.89e-21 | 5.49e-01 | 0.1149 |
79887 | PLBD1 | P16T-E | Human | Esophagus | ESCC | 6.25e-92 | 2.86e+00 | 0.1153 |
79887 | PLBD1 | P17T-E | Human | Esophagus | ESCC | 2.47e-04 | 2.16e-01 | 0.1278 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00066446 | Esophagus | ESCC | phospholipid metabolic process | 218/8552 | 383/18723 | 5.37e-06 | 5.59e-05 | 218 |
GO:00442427 | Esophagus | ESCC | cellular lipid catabolic process | 121/8552 | 214/18723 | 8.63e-04 | 4.43e-03 | 121 |
GO:00160427 | Esophagus | ESCC | lipid catabolic process | 168/8552 | 320/18723 | 7.97e-03 | 2.84e-02 | 168 |
GO:004424222 | Liver | HCC | cellular lipid catabolic process | 134/7958 | 214/18723 | 2.07e-09 | 5.79e-08 | 134 |
GO:00066444 | Liver | HCC | phospholipid metabolic process | 214/7958 | 383/18723 | 7.25e-08 | 1.48e-06 | 214 |
GO:001604221 | Liver | HCC | lipid catabolic process | 175/7958 | 320/18723 | 6.50e-06 | 7.88e-05 | 175 |
GO:00464342 | Liver | HCC | organophosphate catabolic process | 89/7958 | 155/18723 | 1.24e-04 | 1.03e-03 | 89 |
GO:00442426 | Oral cavity | OSCC | cellular lipid catabolic process | 104/7305 | 214/18723 | 2.61e-03 | 1.15e-02 | 104 |
GO:00066445 | Oral cavity | OSCC | phospholipid metabolic process | 175/7305 | 383/18723 | 4.21e-03 | 1.71e-02 | 175 |
GO:004424213 | Oral cavity | LP | cellular lipid catabolic process | 70/4623 | 214/18723 | 4.82e-03 | 3.05e-02 | 70 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PLBD1 | SNV | Missense_Mutation | novel | c.504N>C | p.Gln168His | p.Q168H | Q6P4A8 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PLBD1 | SNV | Missense_Mutation | rs781372711 | c.665G>A | p.Arg222Lys | p.R222K | Q6P4A8 | protein_coding | tolerated(0.37) | benign(0.079) | TCGA-BH-A0DG-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | CR |
PLBD1 | SNV | Missense_Mutation | c.715N>A | p.Glu239Lys | p.E239K | Q6P4A8 | protein_coding | deleterious(0.01) | possibly_damaging(0.882) | TCGA-D8-A1J9-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
PLBD1 | insertion | Nonsense_Mutation | novel | c.438_439insAATGTATGGATGTATTATACAGTATAACAAAAGAAATGCAAATAT | p.Thr146_Arg147insAsnValTrpMetTyrTyrThrValTerGlnLysLysCysLysTyr | p.T146_R147insNVWMYYTV*QKKCKY | Q6P4A8 | protein_coding | TCGA-A2-A0CP-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD | ||
PLBD1 | deletion | Frame_Shift_Del | novel | c.304delN | p.Ala102LeufsTer13 | p.A102Lfs*13 | Q6P4A8 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
PLBD1 | SNV | Missense_Mutation | novel | c.401N>G | p.Lys134Arg | p.K134R | Q6P4A8 | protein_coding | tolerated(0.34) | benign(0.031) | TCGA-C5-A8XK-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD |
PLBD1 | SNV | Missense_Mutation | c.1388N>A | p.Pro463His | p.P463H | Q6P4A8 | protein_coding | deleterious(0) | probably_damaging(0.99) | TCGA-DS-A0VM-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD | |
PLBD1 | SNV | Missense_Mutation | c.1429N>A | p.Glu477Lys | p.E477K | Q6P4A8 | protein_coding | tolerated(0.4) | benign(0.015) | TCGA-EA-A3QD-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | cisplatin | CR | |
PLBD1 | SNV | Missense_Mutation | c.1011N>C | p.Lys337Asn | p.K337N | Q6P4A8 | protein_coding | deleterious(0.04) | benign(0.403) | TCGA-FU-A23L-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
PLBD1 | SNV | Missense_Mutation | c.124N>C | p.Tyr42His | p.Y42H | Q6P4A8 | protein_coding | tolerated(0.2) | possibly_damaging(0.776) | TCGA-A6-2686-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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