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Gene: PLAGL1 |
Gene summary for PLAGL1 |
Gene summary. |
Gene information | Species | Human | Gene symbol | PLAGL1 | Gene ID | 5325 |
Gene name | PLAG1 like zinc finger 1 | |
Gene Alias | LOT1 | |
Cytomap | 6q24.2 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | A1YLA1 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
5325 | PLAGL1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 3.48e-08 | -4.78e-01 | 0.0155 |
5325 | PLAGL1 | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.30e-02 | -4.13e-01 | -0.1808 |
5325 | PLAGL1 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.88e-13 | -4.42e-01 | -0.1464 |
5325 | PLAGL1 | HTA11_866_2000001011 | Human | Colorectum | AD | 1.19e-04 | -3.38e-01 | -0.1001 |
5325 | PLAGL1 | HTA11_866_3004761011 | Human | Colorectum | AD | 1.13e-02 | -3.54e-01 | 0.096 |
5325 | PLAGL1 | HTA11_10711_2000001011 | Human | Colorectum | AD | 8.63e-03 | -4.09e-01 | 0.0338 |
5325 | PLAGL1 | HTA11_7696_3000711011 | Human | Colorectum | AD | 1.66e-07 | -2.64e-01 | 0.0674 |
5325 | PLAGL1 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 5.55e-08 | -3.25e-01 | 0.294 |
5325 | PLAGL1 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 1.36e-12 | -4.21e-01 | 0.3859 |
5325 | PLAGL1 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 8.41e-18 | -5.08e-01 | 0.3005 |
5325 | PLAGL1 | F007 | Human | Colorectum | FAP | 2.15e-02 | -3.67e-01 | 0.1176 |
5325 | PLAGL1 | A001-C-207 | Human | Colorectum | FAP | 1.75e-08 | -4.76e-01 | 0.1278 |
5325 | PLAGL1 | A015-C-203 | Human | Colorectum | FAP | 8.28e-24 | -3.56e-01 | -0.1294 |
5325 | PLAGL1 | A015-C-204 | Human | Colorectum | FAP | 1.01e-05 | -4.00e-01 | -0.0228 |
5325 | PLAGL1 | A014-C-040 | Human | Colorectum | FAP | 5.37e-03 | -4.10e-01 | -0.1184 |
5325 | PLAGL1 | A002-C-201 | Human | Colorectum | FAP | 2.38e-13 | -3.73e-01 | 0.0324 |
5325 | PLAGL1 | A002-C-203 | Human | Colorectum | FAP | 5.52e-04 | -1.85e-01 | 0.2786 |
5325 | PLAGL1 | A001-C-119 | Human | Colorectum | FAP | 3.07e-10 | -5.61e-01 | -0.1557 |
5325 | PLAGL1 | A001-C-108 | Human | Colorectum | FAP | 4.65e-20 | -4.84e-01 | -0.0272 |
5325 | PLAGL1 | A002-C-205 | Human | Colorectum | FAP | 2.36e-24 | -6.20e-01 | -0.1236 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PLAGL1 | insertion | Frame_Shift_Ins | novel | c.869_870insT | p.Gly292TrpfsTer32 | p.G292Wfs*32 | Q9UM63 | protein_coding | TCGA-AN-A04A-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | ||
PLAGL1 | insertion | Nonsense_Mutation | novel | c.868_869insATTAAACAAGAATTTTCTTTGCTCTGTCTAGCTTAAA | p.Ser290TyrfsTer2 | p.S290Yfs*2 | Q9UM63 | protein_coding | TCGA-AN-A04A-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | ||
PLAGL1 | insertion | Nonsense_Mutation | novel | c.868_869insGATAAGAGAATTCTCGAACTGCATGTATTGTGC | p.Ser290delinsTer | p.S290delins* | Q9UM63 | protein_coding | TCGA-BH-A0B4-01 | Breast | breast invasive carcinoma | Male | >=65 | III/IV | Hormone Therapy | tamoxiphen | SD | ||
PLAGL1 | SNV | Missense_Mutation | novel | c.397N>A | p.Glu133Lys | p.E133K | Q9UM63 | protein_coding | tolerated(0.11) | possibly_damaging(0.818) | TCGA-DS-A1OB-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | carboplatin | PD |
PLAGL1 | SNV | Missense_Mutation | c.34N>G | p.Thr12Ala | p.T12A | Q9UM63 | protein_coding | tolerated(0.74) | benign(0.003) | TCGA-FU-A3HZ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
PLAGL1 | SNV | Missense_Mutation | c.326N>G | p.His109Arg | p.H109R | Q9UM63 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AA-3663-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
PLAGL1 | SNV | Missense_Mutation | c.584N>A | p.Arg195His | p.R195H | Q9UM63 | protein_coding | deleterious(0) | probably_damaging(0.936) | TCGA-AA-3811-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | |
PLAGL1 | SNV | Missense_Mutation | novel | c.340N>T | p.Ala114Ser | p.A114S | Q9UM63 | protein_coding | tolerated(0.17) | benign(0.079) | TCGA-AA-3952-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD |
PLAGL1 | SNV | Missense_Mutation | c.1322N>A | p.Pro441His | p.P441H | Q9UM63 | protein_coding | tolerated(0.51) | benign(0.001) | TCGA-AA-A022-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
PLAGL1 | SNV | Missense_Mutation | novel | c.749N>G | p.Asn250Ser | p.N250S | Q9UM63 | protein_coding | tolerated(0.35) | benign(0.015) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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