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Gene: PLAC8 |
Gene summary for PLAC8 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | PLAC8 | Gene ID | 51316 |
| Gene name | placenta associated 8 | |
| Gene Alias | C15 | |
| Cytomap | 4q21.22 | |
| Gene Type | protein-coding | GO ID | GO:0001659 | UniProtAcc | Q9NZF1 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 51316 | PLAC8 | HTA11_2487_2000001011 | Human | Colorectum | SER | 3.51e-22 | 1.75e+00 | -0.1808 |
| 51316 | PLAC8 | HTA11_347_2000001011 | Human | Colorectum | AD | 8.07e-11 | 8.59e-01 | -0.1954 |
| 51316 | PLAC8 | HTA11_411_2000001011 | Human | Colorectum | SER | 6.09e-06 | 2.49e+00 | -0.2602 |
| 51316 | PLAC8 | HTA11_2112_2000001011 | Human | Colorectum | SER | 2.14e-09 | 1.83e+00 | -0.2196 |
| 51316 | PLAC8 | HTA11_3361_2000001011 | Human | Colorectum | AD | 7.24e-04 | 6.39e-01 | -0.1207 |
| 51316 | PLAC8 | HTA11_83_2000001011 | Human | Colorectum | SER | 2.15e-05 | 9.15e-01 | -0.1526 |
| 51316 | PLAC8 | HTA11_696_2000001011 | Human | Colorectum | AD | 6.78e-11 | 1.10e+00 | -0.1464 |
| 51316 | PLAC8 | HTA11_1391_2000001011 | Human | Colorectum | AD | 2.77e-12 | 9.29e-01 | -0.059 |
| 51316 | PLAC8 | HTA11_2992_2000001011 | Human | Colorectum | SER | 4.67e-04 | 1.15e+00 | -0.1706 |
| 51316 | PLAC8 | HTA11_5212_2000001011 | Human | Colorectum | AD | 4.92e-12 | 1.76e+00 | -0.2061 |
| 51316 | PLAC8 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 1.47e-02 | -1.62e-01 | 0.294 |
| 51316 | PLAC8 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 2.70e-07 | -2.58e-01 | 0.3859 |
| 51316 | PLAC8 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 5.50e-09 | -2.89e-01 | 0.3005 |
| 51316 | PLAC8 | A002-C-010 | Human | Colorectum | FAP | 4.63e-05 | -2.24e-01 | 0.242 |
| 51316 | PLAC8 | A015-C-203 | Human | Colorectum | FAP | 5.29e-06 | -1.96e-01 | -0.1294 |
| 51316 | PLAC8 | A002-C-201 | Human | Colorectum | FAP | 3.49e-04 | -2.38e-01 | 0.0324 |
| 51316 | PLAC8 | A002-C-203 | Human | Colorectum | FAP | 1.58e-13 | -2.83e-01 | 0.2786 |
| 51316 | PLAC8 | A001-C-119 | Human | Colorectum | FAP | 1.06e-02 | -2.58e-01 | -0.1557 |
| 51316 | PLAC8 | A001-C-108 | Human | Colorectum | FAP | 3.40e-02 | -1.12e-01 | -0.0272 |
| 51316 | PLAC8 | A002-C-205 | Human | Colorectum | FAP | 6.04e-05 | -2.18e-01 | -0.1236 |
| Page: 1 2 3 4 5 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Colorectum (GSE201348) |  | FAP: Familial adenomatous polyposis |
| CRC: Colorectal cancer | ||
| Colorectum (HTA11) |  | AD: Adenomas |
| SER: Sessile serrated lesions | ||
| MSI-H: Microsatellite-high colorectal cancer | ||
| MSS: Microsatellite stable colorectal cancer | ||
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| GC |  | CAG: Chronic atrophic gastritis |
| CAG with IM: Chronic atrophic gastritis with intestinal metaplasia | ||
| CSG: Chronic superficial gastritis | ||
| GC: Gastric cancer | ||
| SIM: Severe intestinal metaplasia | ||
| WIM: Wild intestinal metaplasia | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:0009409 | Colorectum | AD | response to cold | 22/3918 | 49/18723 | 1.40e-04 | 1.98e-03 | 22 |
| GO:0048638 | Colorectum | AD | regulation of developmental growth | 92/3918 | 330/18723 | 1.48e-03 | 1.25e-02 | 92 |
| GO:0120162 | Colorectum | AD | positive regulation of cold-induced thermogenesis | 32/3918 | 97/18723 | 3.74e-03 | 2.63e-02 | 32 |
| GO:0045926 | Colorectum | AD | negative regulation of growth | 70/3918 | 249/18723 | 4.07e-03 | 2.83e-02 | 70 |
| GO:0106106 | Colorectum | AD | cold-induced thermogenesis | 43/3918 | 144/18723 | 7.05e-03 | 4.31e-02 | 43 |
| GO:0120161 | Colorectum | AD | regulation of cold-induced thermogenesis | 43/3918 | 144/18723 | 7.05e-03 | 4.31e-02 | 43 |
| GO:1990845 | Colorectum | AD | adaptive thermogenesis | 46/3918 | 157/18723 | 7.97e-03 | 4.73e-02 | 46 |
| GO:00094091 | Colorectum | SER | response to cold | 16/2897 | 49/18723 | 2.11e-03 | 2.06e-02 | 16 |
| GO:00459261 | Colorectum | SER | negative regulation of growth | 55/2897 | 249/18723 | 3.44e-03 | 2.92e-02 | 55 |
| GO:0045444 | Colorectum | SER | fat cell differentiation | 51/2897 | 229/18723 | 3.96e-03 | 3.26e-02 | 51 |
| GO:00094092 | Colorectum | MSS | response to cold | 19/3467 | 49/18723 | 7.20e-04 | 7.70e-03 | 19 |
| GO:00486381 | Colorectum | MSS | regulation of developmental growth | 84/3467 | 330/18723 | 1.01e-03 | 1.01e-02 | 84 |
| GO:0035264 | Colorectum | MSS | multicellular organism growth | 37/3467 | 132/18723 | 4.77e-03 | 3.34e-02 | 37 |
| GO:00486382 | Colorectum | FAP | regulation of developmental growth | 75/2622 | 330/18723 | 1.11e-05 | 3.10e-04 | 75 |
| GO:00352641 | Colorectum | FAP | multicellular organism growth | 31/2622 | 132/18723 | 2.28e-03 | 1.84e-02 | 31 |
| GO:0001659 | Colorectum | FAP | temperature homeostasis | 38/2622 | 174/18723 | 3.16e-03 | 2.36e-02 | 38 |
| GO:01061061 | Colorectum | FAP | cold-induced thermogenesis | 32/2622 | 144/18723 | 4.85e-03 | 3.25e-02 | 32 |
| GO:01201611 | Colorectum | FAP | regulation of cold-induced thermogenesis | 32/2622 | 144/18723 | 4.85e-03 | 3.25e-02 | 32 |
| GO:19908451 | Colorectum | FAP | adaptive thermogenesis | 34/2622 | 157/18723 | 5.77e-03 | 3.69e-02 | 34 |
| GO:00094093 | Colorectum | FAP | response to cold | 14/2622 | 49/18723 | 5.95e-03 | 3.75e-02 | 14 |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| PLAC8 | SNV | Missense_Mutation | c.151N>A | p.Gly51Arg | p.G51R | Q9NZF1 | protein_coding | deleterious(0.01) | possibly_damaging(0.711) | TCGA-D8-A1XQ-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| PLAC8 | SNV | Missense_Mutation | c.260N>G | p.Asp87Gly | p.D87G | Q9NZF1 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-E2-A1LS-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Cyclophosphamide | SD | |
| PLAC8 | insertion | Nonsense_Mutation | novel | c.42_43insTCGTGTTGGGCAGGCCGGTCTCAAACTCCTGACATCAAGTGATCTGCC | p.Gly14_Val15insSerCysTrpAlaGlyArgSerGlnThrProAspIleLysTerSerAla | p.G14_V15insSCWAGRSQTPDIK*SA | Q9NZF1 | protein_coding | TCGA-A7-A0CG-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
| PLAC8 | SNV | Missense_Mutation | c.313N>T | p.Asp105Tyr | p.D105Y | Q9NZF1 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
| PLAC8 | SNV | Missense_Mutation | novel | c.167C>T | p.Ala56Val | p.A56V | Q9NZF1 | protein_coding | tolerated(0.05) | benign(0.316) | TCGA-A5-A2K3-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | SD |
| PLAC8 | SNV | Missense_Mutation | rs144318051 | c.338N>A | p.Arg113His | p.R113H | Q9NZF1 | protein_coding | tolerated(0.08) | benign(0) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| PLAC8 | SNV | Missense_Mutation | c.268N>A | p.Ala90Thr | p.A90T | Q9NZF1 | protein_coding | tolerated(0.46) | benign(0.014) | TCGA-B5-A0JY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD | |
| PLAC8 | SNV | Missense_Mutation | c.332C>T | p.Ala111Val | p.A111V | Q9NZF1 | protein_coding | tolerated(0.09) | benign(0.3) | TCGA-B5-A11E-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
| PLAC8 | SNV | Missense_Mutation | c.109N>A | p.Cys37Ser | p.C37S | Q9NZF1 | protein_coding | deleterious(0.03) | possibly_damaging(0.529) | TCGA-B5-A11G-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| PLAC8 | SNV | Missense_Mutation | rs866736651 | c.178N>A | p.Glu60Lys | p.E60K | Q9NZF1 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-B5-A3FA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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