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Gene: PLAAT3 |
Gene summary for PLAAT3 |
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Gene information | Species | Human | Gene symbol | PLAAT3 | Gene ID | 11145 |
Gene name | phospholipase A and acyltransferase 3 | |
Gene Alias | AdPLA | |
Cytomap | 11q12.3-q13.1 | |
Gene Type | protein-coding | GO ID | GO:0001654 | UniProtAcc | A0A024R561 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
11145 | PLAAT3 | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.14e-02 | 1.44e-01 | -0.1808 |
11145 | PLAAT3 | HTA11_1938_2000001011 | Human | Colorectum | AD | 5.45e-19 | 5.08e-01 | -0.0811 |
11145 | PLAAT3 | HTA11_1391_2000001011 | Human | Colorectum | AD | 2.25e-23 | 5.73e-01 | -0.059 |
11145 | PLAAT3 | HTA11_866_3004761011 | Human | Colorectum | AD | 1.58e-03 | 1.18e-01 | 0.096 |
11145 | PLAAT3 | HTA11_6818_2000001021 | Human | Colorectum | AD | 1.37e-04 | 1.70e-01 | 0.0588 |
11145 | PLAAT3 | LZE2T | Human | Esophagus | ESCC | 1.47e-14 | 1.07e+00 | 0.082 |
11145 | PLAAT3 | LZE3D | Human | Esophagus | HGIN | 6.21e-05 | 6.78e-01 | 0.0668 |
11145 | PLAAT3 | LZE4T | Human | Esophagus | ESCC | 2.37e-02 | 1.31e-01 | 0.0811 |
11145 | PLAAT3 | LZE5T | Human | Esophagus | ESCC | 1.40e-06 | 4.15e-01 | 0.0514 |
11145 | PLAAT3 | LZE7T | Human | Esophagus | ESCC | 2.56e-05 | 3.83e-01 | 0.0667 |
11145 | PLAAT3 | LZE24T | Human | Esophagus | ESCC | 1.80e-03 | 1.71e-01 | 0.0596 |
11145 | PLAAT3 | LZE6T | Human | Esophagus | ESCC | 5.26e-07 | 3.11e-01 | 0.0845 |
11145 | PLAAT3 | RNA-P25T1-P25T1-1 | Human | Lung | AIS | 1.60e-12 | 5.12e-01 | -0.2116 |
11145 | PLAAT3 | RNA-P25T1-P25T1-4 | Human | Lung | AIS | 2.98e-05 | 3.32e-01 | -0.2119 |
11145 | PLAAT3 | RNA-P3T-P3T-1 | Human | Lung | IAC | 1.64e-08 | 5.83e-01 | 0.1829 |
11145 | PLAAT3 | RNA-P3T-P3T-2 | Human | Lung | IAC | 3.17e-07 | 5.56e-01 | 0.1835 |
11145 | PLAAT3 | RNA-P3T-P3T-4 | Human | Lung | IAC | 6.77e-09 | 6.09e-01 | 0.1859 |
11145 | PLAAT3 | RNA-P6T2-P6T2-1 | Human | Lung | IAC | 9.94e-07 | 2.81e-01 | -0.0166 |
11145 | PLAAT3 | RNA-P6T2-P6T2-2 | Human | Lung | IAC | 1.48e-12 | 3.97e-01 | -0.0132 |
11145 | PLAAT3 | RNA-P6T2-P6T2-3 | Human | Lung | IAC | 1.19e-11 | 3.68e-01 | -0.013 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0022411 | Colorectum | AD | cellular component disassembly | 147/3918 | 443/18723 | 8.53e-10 | 6.76e-08 | 147 |
GO:1903008 | Colorectum | AD | organelle disassembly | 46/3918 | 114/18723 | 1.81e-06 | 5.48e-05 | 46 |
GO:0016042 | Colorectum | AD | lipid catabolic process | 97/3918 | 320/18723 | 4.31e-05 | 7.56e-04 | 97 |
GO:0018904 | Colorectum | AD | ether metabolic process | 14/3918 | 27/18723 | 3.72e-04 | 4.29e-03 | 14 |
GO:0006662 | Colorectum | AD | glycerol ether metabolic process | 12/3918 | 22/18723 | 5.38e-04 | 5.74e-03 | 12 |
GO:0046485 | Colorectum | AD | ether lipid metabolic process | 10/3918 | 20/18723 | 3.67e-03 | 2.60e-02 | 10 |
GO:0006650 | Colorectum | AD | glycerophospholipid metabolic process | 83/3918 | 306/18723 | 5.40e-03 | 3.55e-02 | 83 |
GO:0006644 | Colorectum | AD | phospholipid metabolic process | 101/3918 | 383/18723 | 5.80e-03 | 3.67e-02 | 101 |
GO:00224111 | Colorectum | SER | cellular component disassembly | 114/2897 | 443/18723 | 1.17e-08 | 9.59e-07 | 114 |
GO:19030081 | Colorectum | SER | organelle disassembly | 36/2897 | 114/18723 | 1.22e-05 | 3.89e-04 | 36 |
GO:00160421 | Colorectum | SER | lipid catabolic process | 77/2897 | 320/18723 | 3.52e-05 | 9.18e-04 | 77 |
GO:0046486 | Colorectum | SER | glycerolipid metabolic process | 82/2897 | 392/18723 | 2.26e-03 | 2.17e-02 | 82 |
GO:00066621 | Colorectum | SER | glycerol ether metabolic process | 9/2897 | 22/18723 | 3.66e-03 | 3.06e-02 | 9 |
GO:00066441 | Colorectum | SER | phospholipid metabolic process | 79/2897 | 383/18723 | 3.94e-03 | 3.24e-02 | 79 |
GO:00189041 | Colorectum | SER | ether metabolic process | 10/2897 | 27/18723 | 5.18e-03 | 3.95e-02 | 10 |
GO:00066501 | Colorectum | SER | glycerophospholipid metabolic process | 64/2897 | 306/18723 | 6.41e-03 | 4.60e-02 | 64 |
GO:00457861 | Lung | IAC | negative regulation of cell cycle | 67/2061 | 385/18723 | 9.74e-05 | 1.93e-03 | 67 |
GO:0030397 | Lung | IAC | membrane disassembly | 6/2061 | 12/18723 | 9.06e-04 | 1.11e-02 | 6 |
GO:00224118 | Lung | IAC | cellular component disassembly | 68/2061 | 443/18723 | 2.89e-03 | 2.60e-02 | 68 |
GO:00464701 | Lung | AIS | phosphatidylcholine metabolic process | 15/1849 | 74/18723 | 5.25e-03 | 4.49e-02 | 15 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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