GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:001657015 | Esophagus | ESCC | histone modification | 323/8552 | 463/18723 | 2.61e-26 | 7.88e-24 | 323 |
GO:0010563111 | Esophagus | ESCC | negative regulation of phosphorus metabolic process | 274/8552 | 442/18723 | 2.32e-12 | 9.41e-11 | 274 |
GO:0045936111 | Esophagus | ESCC | negative regulation of phosphate metabolic process | 273/8552 | 441/18723 | 3.18e-12 | 1.25e-10 | 273 |
GO:0051348111 | Esophagus | ESCC | negative regulation of transferase activity | 177/8552 | 268/18723 | 1.08e-11 | 4.00e-10 | 177 |
GO:0042326111 | Esophagus | ESCC | negative regulation of phosphorylation | 237/8552 | 385/18723 | 1.86e-10 | 5.33e-09 | 237 |
GO:0001933111 | Esophagus | ESCC | negative regulation of protein phosphorylation | 213/8552 | 342/18723 | 3.54e-10 | 9.76e-09 | 213 |
GO:0030522110 | Esophagus | ESCC | intracellular receptor signaling pathway | 170/8552 | 265/18723 | 8.58e-10 | 2.09e-08 | 170 |
GO:003367319 | Esophagus | ESCC | negative regulation of kinase activity | 154/8552 | 237/18723 | 1.38e-09 | 3.27e-08 | 154 |
GO:000646920 | Esophagus | ESCC | negative regulation of protein kinase activity | 140/8552 | 212/18723 | 1.53e-09 | 3.56e-08 | 140 |
GO:0048545111 | Esophagus | ESCC | response to steroid hormone | 204/8552 | 339/18723 | 4.47e-08 | 8.11e-07 | 204 |
GO:0071383110 | Esophagus | ESCC | cellular response to steroid hormone stimulus | 127/8552 | 204/18723 | 1.26e-06 | 1.55e-05 | 127 |
GO:0048872111 | Esophagus | ESCC | homeostasis of number of cells | 163/8552 | 272/18723 | 1.40e-06 | 1.69e-05 | 163 |
GO:00182099 | Esophagus | ESCC | peptidyl-serine modification | 196/8552 | 338/18723 | 3.07e-06 | 3.47e-05 | 196 |
GO:001810515 | Esophagus | ESCC | peptidyl-serine phosphorylation | 184/8552 | 315/18723 | 3.22e-06 | 3.61e-05 | 184 |
GO:003051819 | Esophagus | ESCC | intracellular steroid hormone receptor signaling pathway | 76/8552 | 116/18723 | 1.25e-05 | 1.15e-04 | 76 |
GO:004340119 | Esophagus | ESCC | steroid hormone mediated signaling pathway | 87/8552 | 136/18723 | 1.25e-05 | 1.15e-04 | 87 |
GO:00069707 | Esophagus | ESCC | response to osmotic stress | 57/8552 | 84/18723 | 3.26e-05 | 2.70e-04 | 57 |
GO:00331438 | Esophagus | ESCC | regulation of intracellular steroid hormone receptor signaling pathway | 50/8552 | 74/18723 | 1.16e-04 | 8.04e-04 | 50 |
GO:003052118 | Esophagus | ESCC | androgen receptor signaling pathway | 31/8552 | 44/18723 | 7.70e-04 | 3.99e-03 | 31 |
GO:00718871 | Esophagus | ESCC | leukocyte apoptotic process | 65/8552 | 106/18723 | 8.39e-04 | 4.32e-03 | 65 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PKN1 | SNV | Missense_Mutation | | c.1546N>G | p.Ile516Val | p.I516V | Q16512 | protein_coding | tolerated(0.15) | benign(0.013) | TCGA-AR-A255-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Targeted Molecular therapy | trastuzumab | SD |
PKN1 | SNV | Missense_Mutation | | c.2516G>A | p.Arg839His | p.R839H | Q16512 | protein_coding | deleterious(0.01) | probably_damaging(0.996) | TCGA-BH-A0DD-01 | Breast | breast invasive carcinoma | Male | <65 | I/II | Chemotherapy | docetaxel | CR |
PKN1 | SNV | Missense_Mutation | | c.2205G>C | p.Gln735His | p.Q735H | Q16512 | protein_coding | deleterious(0) | possibly_damaging(0.808) | TCGA-C8-A1HG-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PKN1 | insertion | In_Frame_Ins | novel | c.2613_2614insTGCATGCATGTGCACACTGCCCGTTGT | p.Ala871_Glu872insCysMetHisValHisThrAlaArgCys | p.A871_E872insCMHVHTARC | Q16512 | protein_coding | | | TCGA-A7-A0CG-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PKN1 | insertion | Frame_Shift_Ins | novel | c.546_547insAATGCATGGAAGTACATTT | p.Ile183AsnfsTer8 | p.I183Nfs*8 | Q16512 | protein_coding | | | TCGA-A8-A095-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | CR |
PKN1 | insertion | Frame_Shift_Ins | novel | c.2158_2159insGGCACAGAGAGGTTCAGCAATTTACCCAAGGTCACAC | p.Glu720GlyfsTer84 | p.E720Gfs*84 | Q16512 | protein_coding | | | TCGA-AO-A0J5-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Other, specify in notesBisphosphonate | zoledronic | PD |
PKN1 | SNV | Missense_Mutation | novel | c.1540N>T | p.Met514Leu | p.M514L | Q16512 | protein_coding | tolerated(0.05) | possibly_damaging(0.817) | TCGA-A6-3809-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PKN1 | SNV | Missense_Mutation | rs371928270 | c.362N>T | p.Ala121Val | p.A121V | Q16512 | protein_coding | tolerated(0.27) | benign(0.015) | TCGA-A6-6780-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
PKN1 | SNV | Missense_Mutation | | c.1718C>T | p.Ser573Leu | p.S573L | Q16512 | protein_coding | tolerated(0.29) | benign(0) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR |
PKN1 | SNV | Missense_Mutation | | c.2165N>A | p.Arg722His | p.R722H | Q16512 | protein_coding | deleterious(0.02) | benign(0.073) | TCGA-AA-A01S-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
5585 | PKN1 | DRUGGABLE GENOME, ENZYME, KINASE, SERINE THREONINE KINASE, CLINICALLY ACTIONABLE | inhibitor | 249565832 | | |
5585 | PKN1 | DRUGGABLE GENOME, ENZYME, KINASE, SERINE THREONINE KINASE, CLINICALLY ACTIONABLE | inhibitor | 135652717 | STAUROSPORINE | |
5585 | PKN1 | DRUGGABLE GENOME, ENZYME, KINASE, SERINE THREONINE KINASE, CLINICALLY ACTIONABLE | inhibitor | 178102304 | TOFACITINIB | |
5585 | PKN1 | DRUGGABLE GENOME, ENZYME, KINASE, SERINE THREONINE KINASE, CLINICALLY ACTIONABLE | inhibitor | 249565836 | | |
5585 | PKN1 | DRUGGABLE GENOME, ENZYME, KINASE, SERINE THREONINE KINASE, CLINICALLY ACTIONABLE | inhibitor | SOPHORETIN | QUERCETIN | |
5585 | PKN1 | DRUGGABLE GENOME, ENZYME, KINASE, SERINE THREONINE KINASE, CLINICALLY ACTIONABLE | | INGENOL MEBUTATE | | |