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Gene: PJA1 |
Gene summary for PJA1 |
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Gene information | Species | Human | Gene symbol | PJA1 | Gene ID | 64219 |
Gene name | praja ring finger ubiquitin ligase 1 | |
Gene Alias | PRAJA1 | |
Cytomap | Xq13.1 | |
Gene Type | protein-coding | GO ID | GO:0006464 | UniProtAcc | Q8NG27 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
64219 | PJA1 | LZE4T | Human | Esophagus | ESCC | 5.26e-03 | 1.12e-01 | 0.0811 |
64219 | PJA1 | LZE7T | Human | Esophagus | ESCC | 2.33e-08 | 2.96e-01 | 0.0667 |
64219 | PJA1 | LZE8T | Human | Esophagus | ESCC | 3.14e-03 | 2.05e-01 | 0.067 |
64219 | PJA1 | LZE20T | Human | Esophagus | ESCC | 7.77e-10 | 2.21e-01 | 0.0662 |
64219 | PJA1 | LZE24T | Human | Esophagus | ESCC | 3.07e-15 | 5.06e-01 | 0.0596 |
64219 | PJA1 | LZE21T | Human | Esophagus | ESCC | 2.24e-03 | 1.83e-01 | 0.0655 |
64219 | PJA1 | P1T-E | Human | Esophagus | ESCC | 9.40e-05 | 2.07e-01 | 0.0875 |
64219 | PJA1 | P2T-E | Human | Esophagus | ESCC | 4.37e-20 | 4.63e-01 | 0.1177 |
64219 | PJA1 | P4T-E | Human | Esophagus | ESCC | 1.71e-16 | 3.50e-01 | 0.1323 |
64219 | PJA1 | P5T-E | Human | Esophagus | ESCC | 5.96e-09 | 9.14e-02 | 0.1327 |
64219 | PJA1 | P8T-E | Human | Esophagus | ESCC | 1.12e-28 | 6.09e-01 | 0.0889 |
64219 | PJA1 | P9T-E | Human | Esophagus | ESCC | 1.02e-10 | 2.07e-01 | 0.1131 |
64219 | PJA1 | P10T-E | Human | Esophagus | ESCC | 4.03e-17 | 3.78e-01 | 0.116 |
64219 | PJA1 | P11T-E | Human | Esophagus | ESCC | 6.87e-14 | 5.25e-01 | 0.1426 |
64219 | PJA1 | P12T-E | Human | Esophagus | ESCC | 6.26e-49 | 1.07e+00 | 0.1122 |
64219 | PJA1 | P15T-E | Human | Esophagus | ESCC | 1.75e-25 | 4.05e-01 | 0.1149 |
64219 | PJA1 | P16T-E | Human | Esophagus | ESCC | 1.51e-30 | 6.13e-01 | 0.1153 |
64219 | PJA1 | P17T-E | Human | Esophagus | ESCC | 1.49e-08 | 3.58e-01 | 0.1278 |
64219 | PJA1 | P19T-E | Human | Esophagus | ESCC | 1.15e-03 | 3.92e-01 | 0.1662 |
64219 | PJA1 | P20T-E | Human | Esophagus | ESCC | 7.16e-17 | 2.31e-01 | 0.1124 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PJA1 | SNV | Missense_Mutation | rs763045220 | c.25G>T | p.Val9Leu | p.V9L | Q8NG27 | protein_coding | deleterious(0.05) | benign(0) | TCGA-A1-A0SK-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
PJA1 | SNV | Missense_Mutation | c.171N>A | p.His57Gln | p.H57Q | Q8NG27 | protein_coding | tolerated(0.29) | possibly_damaging(0.446) | TCGA-A2-A04T-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | SD | |
PJA1 | SNV | Missense_Mutation | novel | c.1129C>T | p.Arg377Trp | p.R377W | Q8NG27 | protein_coding | tolerated(0.2) | possibly_damaging(0.451) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PJA1 | SNV | Missense_Mutation | c.1613N>C | p.Met538Thr | p.M538T | Q8NG27 | protein_coding | deleterious(0) | possibly_damaging(0.838) | TCGA-AN-A0FL-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
PJA1 | SNV | Missense_Mutation | novel | c.1354N>C | p.Glu452Gln | p.E452Q | Q8NG27 | protein_coding | tolerated(0.05) | benign(0.259) | TCGA-BH-A0B6-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PJA1 | SNV | Missense_Mutation | c.280G>A | p.Glu94Lys | p.E94K | Q8NG27 | protein_coding | tolerated(0.12) | benign(0.411) | TCGA-BH-A0DZ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | docetaxel | SD | |
PJA1 | SNV | Missense_Mutation | c.254N>T | p.Ser85Leu | p.S85L | Q8NG27 | protein_coding | tolerated(0.55) | probably_damaging(0.978) | TCGA-BH-A0HA-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
PJA1 | SNV | Missense_Mutation | c.581N>A | p.Arg194Lys | p.R194K | Q8NG27 | protein_coding | tolerated(0.3) | benign(0.003) | TCGA-D8-A27G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
PJA1 | SNV | Missense_Mutation | novel | c.1689G>T | p.Glu563Asp | p.E563D | Q8NG27 | protein_coding | deleterious(0.04) | probably_damaging(0.956) | TCGA-LL-A7SZ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | CR |
PJA1 | SNV | Missense_Mutation | novel | c.472N>A | p.Ala158Thr | p.A158T | Q8NG27 | protein_coding | tolerated(0.14) | benign(0.055) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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