Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: PIGP

Gene summary for PIGP

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

PIGP

Gene ID

51227

Gene namephosphatidylinositol glycan anchor biosynthesis class P
Gene AliasDCRC
Cytomap21q22.13
Gene Typeprotein-coding
GO ID

GO:0006464

UniProtAcc

P57054


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
51227PIGPLZE4THumanEsophagusESCC2.42e-092.03e-010.0811
51227PIGPLZE7THumanEsophagusESCC1.07e-025.21e-010.0667
51227PIGPLZE8THumanEsophagusESCC7.19e-065.08e-020.067
51227PIGPLZE20THumanEsophagusESCC7.41e-071.57e-010.0662
51227PIGPLZE22D1HumanEsophagusHGIN9.15e-03-4.11e-020.0595
51227PIGPLZE22THumanEsophagusESCC5.12e-057.63e-020.068
51227PIGPLZE24THumanEsophagusESCC2.26e-111.13e-010.0596
51227PIGPLZE21THumanEsophagusESCC1.03e-021.62e-010.0655
51227PIGPLZE6THumanEsophagusESCC1.97e-052.61e-010.0845
51227PIGPP1T-EHumanEsophagusESCC2.60e-043.67e-010.0875
51227PIGPP2T-EHumanEsophagusESCC4.36e-246.49e-010.1177
51227PIGPP4T-EHumanEsophagusESCC1.01e-531.42e+000.1323
51227PIGPP5T-EHumanEsophagusESCC1.96e-511.24e+000.1327
51227PIGPP8T-EHumanEsophagusESCC6.03e-182.03e-010.0889
51227PIGPP9T-EHumanEsophagusESCC2.21e-255.74e-010.1131
51227PIGPP10T-EHumanEsophagusESCC2.59e-215.10e-010.116
51227PIGPP11T-EHumanEsophagusESCC2.50e-083.70e-010.1426
51227PIGPP12T-EHumanEsophagusESCC1.29e-256.56e-010.1122
51227PIGPP15T-EHumanEsophagusESCC6.15e-202.35e-010.1149
51227PIGPP16T-EHumanEsophagusESCC9.33e-378.52e-010.1153
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
ProstateThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.BPH: Benign Prostatic Hyperplasia
SkinThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AK: Actinic keratosis
cSCC: Cutaneous squamous cell carcinoma
SCCIS:squamous cell carcinoma in situ
ThyroidThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ATC: Anaplastic thyroid cancer
HT: Hashimoto's thyroiditis
PTC: Papillary thyroid cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:00086544EsophagusESCCphospholipid biosynthetic process162/8552253/187232.59e-095.73e-08162
GO:00464744EsophagusESCCglycerophospholipid biosynthetic process135/8552211/187235.75e-081.02e-06135
GO:00066433EsophagusESCCmembrane lipid metabolic process130/8552203/187239.29e-081.54e-06130
GO:00450175EsophagusESCCglycerolipid biosynthetic process154/8552252/187235.20e-076.96e-06154
GO:00066446EsophagusESCCphospholipid metabolic process218/8552383/187235.37e-065.59e-05218
GO:00464673EsophagusESCCmembrane lipid biosynthetic process91/8552142/187237.19e-067.19e-0591
GO:00421573EsophagusESCClipoprotein metabolic process86/8552135/187231.78e-051.57e-0486
GO:00064973EsophagusESCCprotein lipidation62/855292/187232.08e-051.80e-0462
GO:00421583EsophagusESCClipoprotein biosynthetic process64/855296/187232.61e-052.20e-0464
GO:00065063EsophagusESCCGPI anchor biosynthetic process26/855232/187233.97e-053.21e-0426
GO:00066505EsophagusESCCglycerophospholipid metabolic process174/8552306/187234.92e-053.85e-04174
GO:00065053EsophagusESCCGPI anchor metabolic process26/855233/187231.06e-047.43e-0426
GO:00066642EsophagusESCCglycolipid metabolic process63/8552100/187233.55e-042.06e-0363
GO:19035092EsophagusESCCliposaccharide metabolic process63/8552101/187235.25e-042.90e-0363
GO:00464864EsophagusESCCglycerolipid metabolic process211/8552392/187236.51e-043.46e-03211
GO:0009247EsophagusESCCglycolipid biosynthetic process42/855268/187235.48e-032.05e-0242
GO:00066611EsophagusESCCphosphatidylinositol biosynthetic process73/8552131/187231.31e-024.28e-0273
GO:0042157LiverCirrhoticlipoprotein metabolic process53/4634135/187231.32e-041.29e-0353
GO:0006643LiverCirrhoticmembrane lipid metabolic process69/4634203/187231.89e-031.19e-0269
GO:0042158LiverCirrhoticlipoprotein biosynthetic process36/463496/187233.69e-032.03e-0236
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
hsa005632EsophagusESCCGlycosylphosphatidylinositol (GPI)-anchor biosynthesis21/420526/84651.10e-033.42e-031.75e-0321
hsa0056311EsophagusESCCGlycosylphosphatidylinositol (GPI)-anchor biosynthesis21/420526/84651.10e-033.42e-031.75e-0321
hsa00563LiverHCCGlycosylphosphatidylinositol (GPI)-anchor biosynthesis18/402026/84652.08e-024.81e-022.68e-0218
hsa005631LiverHCCGlycosylphosphatidylinositol (GPI)-anchor biosynthesis18/402026/84652.08e-024.81e-022.68e-0218
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
PIGPSNVMissense_Mutationc.170N>Tp.Trp57Leup.W57Lprotein_codingdeleterious(0)probably_damaging(1)TCGA-AD-6889-01Colorectumcolon adenocarcinomaMale>=65I/IIChemotherapyxelodaPD
PIGPSNVMissense_Mutationnovelc.127N>Ap.Leu43Ilep.L43Iprotein_codingdeleterious(0.05)possibly_damaging(0.5)TCGA-CA-6717-01Colorectumcolon adenocarcinomaMale<65I/IIChemotherapyoxaliplatinCR
PIGPSNVMissense_Mutationc.17C>Tp.Thr6Ilep.T6Iprotein_codingtolerated_low_confidence(0.12)benign(0.013)TCGA-CL-5917-01Colorectumrectum adenocarcinomaFemale>=65III/IVUnknownUnknownSD
PIGPSNVMissense_Mutationrs140253885c.442N>Gp.Phe148Valp.F148Vprotein_codingdeleterious(0)possibly_damaging(0.904)TCGA-AP-A059-01Endometriumuterine corpus endometrioid carcinomaFemale>=65I/IIUnknownUnknownSD
PIGPSNVMissense_Mutationc.239N>Ap.Val80Aspp.V80Dprotein_codingdeleterious(0)probably_damaging(0.968)TCGA-AX-A05Z-01Endometriumuterine corpus endometrioid carcinomaFemale<65III/IVChemotherapyadriamycinSD
PIGPSNVMissense_Mutationc.359N>Cp.Lys120Thrp.K120Tprotein_codingtolerated(0.17)possibly_damaging(0.506)TCGA-B5-A0JY-01Endometriumuterine corpus endometrioid carcinomaFemale<65III/IVChemotherapydoxorubicinSD
PIGPSNVMissense_Mutationnovelc.82N>Cp.Asn28Hisp.N28Hprotein_codingtolerated(0.35)probably_damaging(0.937)TCGA-EO-A3AV-01Endometriumuterine corpus endometrioid carcinomaFemale<65III/IVChemotherapycarboplatinCR
PIGPSNVMissense_Mutationnovelc.202N>Gp.Leu68Valp.L68Vprotein_codingtolerated(0.21)benign(0.034)TCGA-EO-A3B0-01Endometriumuterine corpus endometrioid carcinomaFemale<65III/IVUnknownUnknownSD
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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